Pomegranate peel anthocyanins prevent diet-induced obesity and insulin resistance in association with modulation of the gut microbiota in mice

Song, Haizhao; Shen, Xinchun; Deng, Rou; Chu, Qiang; Zheng, Xiaodong

doi:10.1007/s00394-021-02771-1

Cited by 15 publications

(6 citation statements)

References 52 publications

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“…Moreover, the analysis of β-diversity revealed a clear separation between the gut microbiota of VA and RA groups compared to the HFD group, and their composition was more similar to that of the Chow group. These results suggested that the intake of VA and RA may exert their antiobesity effects by modulating the diversity of the gut microbiota, which is consistent with the study of Euterpe oleracea Mart anthocyanin and Pomegranate peel anthocyanins increasing the microbial diversity. , …”

Section: Discussionsupporting

confidence: 90%

“…These results suggested that the intake of VA and RA may exert their antiobesity effects by modulating the diversity of the gut microbiota, which is consistent with the study of Euterpe oleracea Mart anthocyanin and Pomegranate peel anthocyanins increasing the microbial diversity. 57,58 Generally, the intervention of HFD can disrupt the balance of the gut microbiota, especially by increasing the abundance of Firmicutes, decreasing the abundance of Bacteroidetes, and elevating the ratio of F/B, which was significantly associated with obesity and diabetes. 59 In our study, it was discovered that Bacteroidetes and Firmicutes were the dominant phyla in the four groups, similar to previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Du,

Lü,

Chen

et al. 2023

J. Agric. Food Chem.

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In this study, blueberry (Vaccinium ssp.) anthocyanins (VA) and blackberry (Rubus L.) anthocyanins (RA) were used to investigate the effects on metabolic syndrome (MetS) and the potential mechanisms. Importantly, all of the data presented in this study were obtained from experiments conducted on mice. As a result, VA and RA reduced body weight gain and fat accumulation while improving liver damage, inflammation, glucose, and lipid metabolism induced by a high-fat diet. Moreover, VA and RA regulated the gut microbiota composition, decreasing the pro-obesity and proinflammation bacteria taxa, such as the phylum Actinobacterium and the genera Allobaculum and Bifidobacterium, and increasing those negatively associated with obesity and inflammation, such as the phylum Bacteroidetes and the genera Prevotella and Oscillospira. Additionally, the supplementation with VA and RA reversed the elevated levels of valeric, caproic, and isovaleric acids observed in the high-fat diet (HFD) group, bringing them closer to the levels observed in the Chow group. This reversal indicated that alterations in the composition and abundance of gut microbiota may contribute to the restoration of short-chain fatty acids (SCFAs) levels. Additionally, PICRUSt2 exhibited that cyanamino acid metabolism and betalain biosynthesis might be the major metabolic pathways in the HVA group compared with the HFD group, while in the HRA group, it was the phosphotransferase system. These findings suggest that VA and RA can ameliorate MetS by modulating the gut microbiota and production of SCFAs.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Du,

Lü,

Chen

et al. 2023

J. Agric. Food Chem.

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“…Pomegranate extract can also decrease appetite and calorie intake by decreasing leptin and elevating adiponectin levels (Al‐Muammar & Khan, 2012). Some animal studies also indicated that pomegranate polyphenols can have a favorable influence on obesity by modulating gut microbiota (Song, Shen, Chu, & Zheng, 2022; Song, Shen, Deng, et al., 2022). Firmicutes and Bacteroidetes are among the primary phyla in the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Bahari,

Pourreza,

Goudarzi

et al. 2023

Food Science & Nutrition

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Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta‐analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat‐free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023. Heterogeneity tests of the included trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. Pooled analysis of 28 trials revealed that pomegranate consumption led to a significant reduction in body weight (WMD: −1.97, 95% CI: −2.91, −1.03, p < .05), and a significant decrease in BMI (WMD: −0.48, 95% CI: −0.76, −0.20, p < .05) in comparison with the control group. However, there were no significant effects on WC, FM, FFM, and BFP in comparison with the control group. Pomegranate consumption may yield a beneficial effect on body weight and BMI in adults. However, there were no significant effects on WC, FM, FFM, and BFP, by pomegranate consumption. Also, pomegranate consumption can reduce body weight, BMI, WC, and BFP in obese adults. Long‐term trials with different doses of pomegranate are needed.

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“…Numerous studies have shown that a high-polyphenol food intake is closely related to human obesity and weight control [ 14 ]. Table 1 [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] summarizes the representative anti-obesity polyphenols and their dietary sources.…”

Section: Dietary Polyphenols’ Impact On Obesitymentioning

confidence: 99%

“…One of the causes of the development of obesity and metabolism-related diseases may be changes in gut bacteria. In a high-fat diet (HFD)-induced obese model, body weight and steatosis scores were reduced after pomegranate peel anthocyanins treatment [ 33 ]. This effect lies in pomegranate peel anthocyanins reducing the ratio of Firmicutes or Bacteroidetes and increasing the abundance of Akkermansia muciniphila .…”

Section: Dietary Polyphenols’ Impact On Obesitymentioning

confidence: 99%

Targeting mTOR Signaling by Dietary Polyphenols in Obesity Prevention

Cao

Han

et al. 2022

Nutrients

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Dietary polyphenols can be utilized to treat obesity and chronic disorders linked to it. Dietary polyphenols can inhibit pre-adipocyte proliferation, adipocyte differentiation, and triglyceride accumulation; meanwhile, polyphenols can also stimulate lipolysis and fatty acid β-oxidation, but the molecular mechanisms of anti-obesity are still unclear. The mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cell growth, survival, metabolism, and immunity. mTOR signaling is also thought to play a key role in the development of metabolic diseases such as obesity. Recent studies showed that dietary polyphenols could target mTOR to reduce obesity. In this review, we systematically summarized the research progress of polyphenols in preventing obesity through the mTOR signaling pathway. Mechanistically, polyphenols can target multiple signaling pathways and gut microbiota to regulate the mTOR signaling pathway to exert anti-obesity effects. The main mechanisms include: modulating lipid metabolism, adipogenesis, inflammation, etc. Dietary polyphenols exerting an anti-obesity effect by targeting mTOR signaling will broaden our understanding of the anti-obesity mechanisms of polyphenols and provide valuable insights for researchers in this novel field.

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Pomegranate peel anthocyanins prevent diet-induced obesity and insulin resistance in association with modulation of the gut microbiota in mice

Cited by 15 publications

References 52 publications

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Targeting mTOR Signaling by Dietary Polyphenols in Obesity Prevention

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