Pomegranate juice increases levels of paraoxonase1 (PON1) expression and enzymatic activity in streptozotocin-induced diabetic mice fed with a high-fat diet

Betanzos‐Cabrera, Gabriel; Guerrero-Solano, José Antonio; Martínez-Pérez, M.M.; Calderón-Ramos, Zuli Guadalupe; Belefant-Miller, Helen; Cancino-Diaz, Mario E.

doi:10.1016/j.foodres.2011.01.042

Cited by 30 publications

(26 citation statements)

References 40 publications

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“…Supplements with pomegranate juice significantly induced PON1 gene expression and activity in mice. In addition, blood glucose was dramatically reduced by the pomegranate juice, but not triacylglycerols and cholesterol levels [74]. Additionally, in the study of Potter et al [51], the plasma total antioxidant capacity was significantly increased ( p < 0.05) and the plasma malondialdehyde production was decreased ( p < 0.05) after consuming 16 fl oz of fresh carrot juice daily for three months.…”

Section: Mechanisms Of Action Of Juice On Cardiovascular Diseasesmentioning

confidence: 99%

Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases

Zheng

Zhou

et al. 2017

IJMS

134

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Many studies have indicated that consumption of vegetables and fruits are positively related to lower incidence of several chronic noncommunicable diseases. Although composition of fruit and vegetable juices is different from that of the edible portion of fruits and vegetables, they contain polyphenols and vitamins from fruits and vegetables. Drinking vegetable and fruit juices is very popular in many countries, and also an efficient way to improve consumption of fruits and vegetables. The studies showed that fruit and vegetable juices affect cardiovascular risk factors, such as lowering blood pressure and improving blood lipid profiles. The main mechanisms of action included antioxidant effects, improvement of the aspects of the cardiovascular system, inhibition of platelet aggregation, anti-inflammatory effects, and prevention of hyperhomocysteinemia. Drinking juices might be a potential way to improve cardiovascular health, especially mixtures of juices because they contain a variety of polyphenols, vitamins, and minerals from different fruits and vegetables. This review summarizes recent studies on the effects of fruit and vegetable juices on indicators of cardiovascular disease, and special attention is paid to the mechanisms of action.

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Section: Mechanisms Of Action Of Juice On Cardiovascular Diseasesmentioning

confidence: 99%

Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases

Zheng

Zhou

et al. 2017

IJMS

134

View full text Add to dashboard Cite

show abstract

“…Although it is known that diabetes is associated with increased oxidative stress and the development of atherosclerosis (Mooradian, 2009), no expression studies have been examined in a diabetic model that is fed with high fat. Therefore, Betanzos-Cabrera et al (2011) investigated whether pomengranate juice induces PON1 gene expression and activity, especially in conditions known for affecting PON1 enzymatic function. The feeding of streptozotocin-induced diabetic mice with a high-fat diet supplemented daily with pomegranate juice significantly induced PON1 gene expression and activity.…”

Section: Antidiabetic Properties (Glucose and Lipid Metabolism Activity)mentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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“…Epidemiological studies show that consumption of pomegranate correlates with reduced cardiovascular and cerebrovascular diseases, anti-diabetic and anti-inflammatory activity and reduced cancer mortality [8][9][10][11][12][13][14][15][16][17][18][19]. Other studies suggest that some compounds of the pomegranate juice are characterized by antioxidant, antimicrobial and antiviral activities [20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%