Pomegranate juice consumption reduces oxidative stress and low density lipoprotein atherogenic modifications: studies in the atherosclerotic apolipoprotein E deficient mice and in humans

Supplementation with Hydroxytyrosol and Punicalagin Improves Early Atherosclerosis Markers Involved in the Asymptomatic Phase of Atherosclerosis in the Adult Population: A Randomized, Placebo-Controlled, Crossover Trial

“…On the other hand, numerous studies have reported a reduction in oxLDL levels after the intake of foods rich in HT or PC [40,44,67,69,70,71]. In a crossover clinical trial in healthy subjects, it was reported that the consumption of 25 mL/day virgin olive oil (~3.75 mg/day phenolic compounds) for 3 weeks significantly reduced plasma oxLDL levels [69].…”

“…Other authors have reported that the long-term consumption of 50 mL/day pomegranate juice (~85 mg of PC) significantly reduces oxLDL levels in patients with carotid artery stenosis [67]. PC may provide this benefit through a direct antioxidant effect on c-LDL, by increasing serum PON-1 levels, and/or by reducing the capacity of macrophages to oxidize c-LDL [67,70,71]. However, in the present work, although supplementation with HT and PC reduced the formation of oxLDL, no change was observed in serum PON-1 levels or, indeed, in any other oxidative status variables (TBARS, FRAP, 8-iso-PGF 2α , and NOx).…”

Total anthocyanin, flavonoid, polyphenol and tannin contents of seven pomegranate cultivars grown in Iran [pdf]

“…The pomegranate is renowned as the 'Paradise fruit' in Iranian culture. The seeds of pomegranate were considered to be an agent of resurrection by Babylonians; the Persians believed the seeds helped invincibility on the battlefields; in ancient China the seeds signified longevity and immortality (Aviram et al, 2000). The antioxidant activity of the pomegranate has been previously evaluated (Ambigaipalan et al, 2017;Mphahlele et al, 2016;Turgut et al, 2017).…”

The Effect of Lyophilized Pomegranate Extract on Epididymal Sperm Quality, Oxidative Stress and Spermatogenic Cell Density in Rabbits

“…Punicalagin is a basic ellagitannin which decomposes into ellagic acid and other small polyphenols in vivo (Seeram et al, 2004). Pomegranate's capacity of iron reduction and activity of free radical-scavenging is three times higher than those in usage of red wine and green tea for antioxidant purposes (Fuhrman et al, 2000). Furthermore, pomegranate content of antioxidant is higher than those of orange juice, blueberry, grape, and grapefruit (Seeram et al, 2006).…”