Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice

Mori-Okamoto, Junko; Otawara-Hamamoto, Yoko; Yamato, Hideyuki; Yoshimura, Hidetoshi

doi:10.1016/j.jep.2004.02.006

Cited by 103 publications

(79 citation statements)

References 30 publications

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“…The decreased level of BALP was ameliorated by CES powder treatment better than alendronate treatment. This may indicate a positive effect on osteoblast differentiation, particularly bone mineralization (Mori-Okamoto et al, 2004) and a higher osteoblast activity account for bone formation which in turn prevents osteoporosis (Omara et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Debernard et al (1986) reported that BALP could act as a plasma membrane transporter for inorganic phosphate, or an extracellular calcium-binding protein that stimulates calcium phosphate precipitation and orients mineral deposition into osteoid. BALP may also be involved in the mineralization process by hydrolyzing organic phosphates to release free inorganic phosphorus at sites of mineralization (Mori-Okamoto et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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The efficacy of Coelatura aegyptiaca shell powder (CES, 500 mg/kg BW) was evaluated as a calcium supplement in ovariectomized (OVX) rats for ten weeks of treatment. The biochemical components and the antioxidant properties of the shell powder were determined. The bone mineral density (BMD), bone mineral content (BMC), calcium (Ca) and phosphorus (P) contents in serum and bone, serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP), serum calcitonin and parathyroid (PTH) hormones were determined. Furthermore, some of the oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant capacity (TAC)] were estimated in bone. The current study revealed that CES contained 19.38% Ca, 0.315% P as well as some of antioxidant amino acids which have a potent antioxidant activity against 1,1-diphenylpicrylhydrazyl (DPPH) free radical. Administration of CES to OVX rats increased BMD, BMC, tibial Ca and P contents and BALP activity, as compared to OVX rats. An ameliorative effect was recorded in the levels of calcitonin, PTH, MDA, SOD, GPx and TAC subsequent to CES administration to OVX rats.This ameliorative effect of CES powder against osteoporosis may be attributed to its antioxidant efficacy and/or to its Ca content. In conclusion, CES may have the potential to develop a clinically useful anti-osteoporotic agent, since its effect was comparable with alendronate (6.5 mg/kg BW/week).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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“…We therefore suggest that pomegranate extract may improve ossification in fetuses without side effects such as osteopoenia in their mothers. Other researchers have also shown positive effects of pomegranate extract on bone properties in the menopausal syndrome (11) and in a model of osteoarthritis (12,20) . Coumoestrol, one of the phytooestrogenic components of pomegranate, was found to enhance neonatal and adult mice osteoblast proliferation (4) .…”

Section: In Vitro Studymentioning

confidence: 92%

Effects of pomegranate extracts on cartilage, bone and mesenchymal cells of mouse fetuses

2011

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Pomegranate is a rich source of polyphenols, which are believed to be responsible for the oestrogenic activities of extracts of this fruit in mice. One of these potential activities is the prevention of bone loss. The objectives of the present study were to determine the effects of pomegranate extract on chondrogenesis and osteogenesis in mouse embryos in vivo and limb bud cultures in vitro. A total of fifty pregnant Balb/c mice were given vehicle, pomegranate juice extract (PJE), pomegranate husk extract (PHE) or a mixture of husk and juice extract (PME). Their embryos were stained with alizarin red S and alcian blue, and the length of the femur, tibia and their ossification zones were measured on day 19 of gestation. Bone Ca content in pregnant mice was also measured. Mice treated with PJE showed an increase in bone Ca content. Dietary supplementation with all extracts significantly increased embryo femur length and osteogenesis index. Mesenchymal cells from fetal limb buds were cultured and exposed to 10, 100, 1000 and 10 000 mg/ml of PJE, PHE or PME. The number of viable cells was greater in cultures exposed to the extracts than in control cultures. The number of cartilage nodules and their diameters were greater in extract-treated cell cultures, a finding which reflected increased cell proliferation and differentiation rates. In conclusion, the findings of the present study suggest that pomegranate is able to enhance bone formation.

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“…Preclinical studies have reported that the juice of pomegranate reduced menopausal symptoms in animal models by inducing antidepressant-like efects and decreasing bone loss [92]. In our laboratory, an extract of pomegranate in the elevated plus-maze for the screening of anxiolytic action and the forced swimming test for an antidepressant-like efect (unpublished results) was evaluated.…”

Section: Punica Granatum L (Lythraceae)mentioning

confidence: 99%

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Estrada‐Camarena¹,

López‐Rubalcava²,

Sustaita³

et al. 2017

A Multidisciplinary Look at Menopause

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Menopause transition is recognized as a vulnerable period in women life to develop or aggravate symptoms of psychiatric disorders. Several treatments including antidepressants and hormonal restitution with estrogens have been suggested to ameliorate the symptoms. Also, in this period of life is frequent the use of other drugs to treat is also frequent the use of other drugs to treat comorbid pathologies that might even increase the risk of drug-drug interactions. Literature reports that some phytochemicals with estrogenic activity have beneicial efects during menopausal transition without collateral events. This chapter shows evidence about the use of phytoestrogens as an alternative therapy for the treatment of some psychiatric symptoms associated with the menopausal transition. Data derived from preclinical research related to the use of classical phytoestrogens (isolavones), considering the beneicial efects, as well as adverse events, are discussed. Also, the use of polyphenols and organosulfurate compounds as an alternative for the treatment of anxiety-and depressive-like behavior as well as ibromyalgia is included. A narrative review was conducted using bibliography reporting the use of isolavones (genistein, daidzein, equol), coumestans or lignans for the reduction of depressive-like or anxiety-like behavior. Furthermore, it is described if the use of this compounds impact in other signs of menopause, i.e. vasomotor and osteoporosis. In addition, due to the high frequency of comorbid pathologies as diabetes mellitus, dyslipidemia or metabolic syndrome with psychiatric disorders, the use of these phytochemicals is discussed.

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Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice

Cited by 103 publications

References 30 publications

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Effects of pomegranate extracts on cartilage, bone and mesenchymal cells of mouse fetuses

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

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