2016
DOI: 10.1177/1721727x15624698
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POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiation

Abstract: Objective: Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC e… Show more

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Cited by 4 publications
(4 citation statements)
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“…Additionally, it was concluded that the genetic disruption of COX-2 has a positive effect in hematopoiesis under basal conditions, but is detrimental following radiation exposure ( 24 ). Ozbilgin et al ( 25 ) indicated that the increased expression of COX-1 and COX-2 in the urothelium of mice may prevent bladder damage from acute gamma-ray radiation, and benefits the differentiation and restoration of the urothelium. Zuo et al ( 26 ) reported that, treatment of mouse epidermal cells with a low concentration of arsenite increased the expression of COX-2, and this induction of COX-2 resulted in decreased levels of apoptosis following ultraviolet B treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, it was concluded that the genetic disruption of COX-2 has a positive effect in hematopoiesis under basal conditions, but is detrimental following radiation exposure ( 24 ). Ozbilgin et al ( 25 ) indicated that the increased expression of COX-1 and COX-2 in the urothelium of mice may prevent bladder damage from acute gamma-ray radiation, and benefits the differentiation and restoration of the urothelium. Zuo et al ( 26 ) reported that, treatment of mouse epidermal cells with a low concentration of arsenite increased the expression of COX-2, and this induction of COX-2 resulted in decreased levels of apoptosis following ultraviolet B treatment.…”
Section: Discussionmentioning
confidence: 99%
“…The H‐score was assigned using the following formula, ∑Pi ( i + 1), which was used as the sum of the percentage of stained cells at each intensity category. For every piece of data, five different slides were calculated by at least two independent, blind researchers 12 …”
Section: Methodsmentioning
confidence: 99%
“…For every piece of data, five different slides were calculated by at least two independent, blind researchers. 12…”
Section: Immunohistochemical Analysismentioning
confidence: 99%
“…In order to support such histopathological evidences, immunohistochemical staining can be employed to better visualize features such as urothelium loss and loss of smooth muscle (e.g., with markers COX-1/2 and UP-III) (52,65).…”
Section: Histopathological Model Of Rcmentioning
confidence: 99%