Polyvinylpyrrolidone-stabilised gold nanoparticle coatings inhibit blood protein adsorption
Hanuma Reddy Tiyyagura,
Rebeka Rudolf,
Matej Bracic
Abstract:In this work, the ability of polyvinylpyrrolidone (PVP)-stabilised gold nanoparticle (AuNP) coatings to inhibit blood protein adsorption was evaluated by studying time-resolved solid–liquid interactions of the coatings with the model blood protein bovine serum albumin (BSA). Inhibiting unspecific blood protein adsorption is of crucial importance for blood-contacting implant devices, e.g. vascular grafts, stents, artificial joints, and others, as a preventive strategy for bacterial biofilm formation. A quartz c… Show more
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