Polyvinylpyrrolidone/hyaluronic acid-based bilayer constructs for sequential delivery of cutaneous antiseptic and antibiotic

Contardi, Marco; Russo, Debora; Suarato, Giulia; Heredia‐Guerrero, José A.; Ceseracciu, Luca; Penna, Ilaria; Margaroli, Natasha; Summa, Maria; Spanò, Raffaele; Tassistro, Giovanni; Vezzulli, Luigi; Bandiera, Tiziano; Bertorelli, Rosalia; Athanassiou, Athanassia; Bayer, Ilker S.

doi:10.1016/j.cej.2018.10.048

Cited by 52 publications

(40 citation statements)

References 74 publications

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“…The presence of the hyaluronic acid controlled the release of ciprofloxacin for five days, whereas a faster, burst-like release was observed without hyaluronic acid. The developed membrane was effective against S. aureus, E. coli, and P. aeruginosa [189]. It remains to be seen whether this system will promote faster wound healing and exhibit antimicrobial effects in vivo; however, they did report that the membrane did not present any complications or toxic effects in an in vivo mouse model with a full-thickness excisional wound.…”

Section: Hydrogelsmentioning

confidence: 99%

“…While it does not have any inherent antimicrobial properties, it can improve wound healing, thus limiting wound exposure to pathogens [40,188]. It can also serve as the starting material for hydrogel formation and modify the release of antimicrobial agents [178,185,189,190]. Contardi et al combined polyvinylpyrrolidone and hyaluronic acid into a bilayer membrane loaded with ciprofloxacin as a treatment for infection and to assist in remodeling of the wounded tissue [189].…”

Section: Hydrogelsmentioning

confidence: 99%

“…It can also serve as the starting material for hydrogel formation and modify the release of antimicrobial agents [178,185,189,190]. Contardi et al combined polyvinylpyrrolidone and hyaluronic acid into a bilayer membrane loaded with ciprofloxacin as a treatment for infection and to assist in remodeling of the wounded tissue [189]. The presence of the hyaluronic acid controlled the release of ciprofloxacin for five days, whereas a faster, burst-like release was observed without hyaluronic acid.…”

Section: Hydrogelsmentioning

confidence: 99%

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Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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Section: Hydrogelsmentioning

confidence: 99%

Section: Hydrogelsmentioning

confidence: 99%

Section: Hydrogelsmentioning

confidence: 99%

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Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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“…Intelligent wound dressings can be made from several polymers and active compounds that can be infused with medicinal compounds to accelerate and manage the healing process. Among them, the biocompatible synthetic polymer polyvinylpyrrolidone (PVP) has gained interest in the topical application not only because it can modulate the crystallinity of several drugs favourably but also for its capacity to form transparent films and ensure good self-adhesion to the moist skin [23][24][25] . In recent years, the natural polymer hyaluronic acid (HA) has also played an important role in the pharmaceutical field due to its anti-inflammatory, regenerative and anti-age properties.…”

mentioning

confidence: 99%

“…In this work, we attempted to use polymeric smart wound dressings in tandem, inspired by human skin wound care and management to cure coral wounds. In particular, we used a dual-drug carrying PVP-HA-based bilayer construct, loaded with eosin-based antiseptic and the antibiotic Ciprofloxacin, as well as a ε-caprolactone-p-coumaric acid copolymer (PCL-PCA) developed for skin regeneration 25,30 .…”

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confidence: 99%

Treatment of Coral Wounds by Combining an Antiseptic Bilayer Film and an Injectable Antioxidant Biopolymer

Contardi

Montano

Liguori

et al. 2020

Sci Rep

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coral reefs are vital for the marine ecosystem and their potential disappearance can have unequivocal consequences on our environment. Aside from pollution-related threats (changes in water temperature, plastics, and acidity), corals can be injured by diseases, predators, humans and other invasive species. Diseases play an important role in this decline, but so far very few mitigation strategies have been proposed and developed to control this threat. in this work, we demonstrate that recently developed bi-layer human skin wound treatment patches containing antiseptics and natural antioxidants with controlled-release capacity can be adapted to treat scleractinian coral wounds effectively. A hydrophilic bilayer film based on polyvinylpyrrolidone (PVP) and hyaluronic acid was used to cover the open wounds while delivering the antiseptics for rapid action. Afterwards, the hydrophilic bi-layer covered wound was sealed with an antioxidant and hydrophobic ε-caprolactone-p-coumaric acid copolymer by melt injection at low temperatures. treated coral injuries were monitored both in aquaria system and in natural environment in Maldives for over 4 months to reduce the number of entry points for organisms that could lead to diseases. the corals well-tolerated both biomaterials as well as the antiseptics incorporated in these materials. the treatments displayed self-adhering properties, tuneable dissolution time, and biocompatibility and stimulated regeneration properties within the coral wound. As such, this work demonstrates that certain human skin wound treatment materials can be successfully adapted to the curing of coral wounds and delivery of specific drugs to slow down, reduce or even stop the spread of diseases in scleractinian corals as well as in all other benthic organisms affected by uncontrolled pathologies.

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Multifunctional Micro/Nanofiber Based‐Dressing Patch with Healing, Protection, and Monitoring Capabilities for Advanced Wound Care

Kim

et al. 2023

Adv Materials Technologies

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Considerable efforts have been devoted to developing wound dressings with various functions, including rapid cell proliferation, protection against infection, and wound state monitoring to minimize severe pain and the risks of wound‐caused secondary infections. However, it remains challenging to diagnose wound conditions and achieve integration of the above functions without specialized equipment and expertise in wound care. This study describes an electrospun composite micro/nanofiber‐based bilayer‐dressing patch comprising a healing‐support layer (hyaluronic acid, gelatin, and dexpanthenol) and a protective/monitoring layer (curcumin and polycaprolactone). The improved cell regeneration function and biocompatibility of the healing‐support layer enable rapid healing, as evidenced by the expedited growth of fibroblasts. The superior antimicrobial properties (against Escherichia coli and Staphylococcus aureus) and visible color changes within the pH range of wound lesions (pH 6–9) of the protective/monitoring layer make the dressing suitable for advanced wound care. The wounds inflicted on BALB/c mice heal rapidly (12 days) without scars while the wound state can be diagnosed by the change in color of the dressing patch. The multifunctional wound dressing patch developed in this study is expected to promote wound healing and monitor wound state; thus, facilitating convenient wound management.

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Polyvinylpyrrolidone/hyaluronic acid-based bilayer constructs for sequential delivery of cutaneous antiseptic and antibiotic

Cited by 52 publications

References 74 publications

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Treatment of Coral Wounds by Combining an Antiseptic Bilayer Film and an Injectable Antioxidant Biopolymer

Multifunctional Micro/Nanofiber Based‐Dressing Patch with Healing, Protection, and Monitoring Capabilities for Advanced Wound Care

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