Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage

Li, Pengpeng; Cao, Lina; Sang, Feng; Zhang, Bingxu; Meng, Zhizhen; Pan, Lingling; Hao, Jiahui; Xiao, Yang; Ma, Zhiyan; Shi, Changcan

doi:10.1016/j.msec.2022.112698

Cited by 21 publications

(31 citation statements)

References 53 publications

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“…The sponges with high porosity could absorb water from blood quickly, concentrate blood components, and accelerate clotting. 15,21,23,32 As shown in Figure S2, the contact angle between blood and the sponge surface was below 90°. The results showed that the GelMA sponge had a high affinity for blood due to the hydrophilic groups on the surface.…”

Section: Preparation Of Different Gelma Spongesmentioning

confidence: 94%

“…To prepare a sponge with ordered conical microchannels, we previously prepared PVA/SA composite sponges via the 3D printing sacrificial template method. Results showed that the PVA-SA composite sponge with conical microchannels not only had better hemostatic ability than the sponge with cylindrical microchannels but also avoided excessive blood-sucking during the whole hemostatic process …”

Section: Introductionmentioning

confidence: 99%

“…Mechanical hemostats were under active development and received increasing attention in recent years. It has been reported that mechanical hemostats, such as shape memory foams, , composite hydrogels, − and multifunctional sponges, , could passively interact with blood by mechanical efforts (such as expansion pressure, − electrostatic attraction, , and adhering to tissues via covalent bonding and/or noncovalent interactions , ) to impart hemostasis. This feature allows mechanical hemostats to be independent of body coagulation cascades and blood disorders for ensuring wide applicability.…”

Section: Introductionmentioning

confidence: 99%

“…We designed GelMA sponges with different taper microchannels, namely, C-GS, GS-0.6, GS-0.8, and GS-1. When contacting the blood, the disordered micropore structure of the sponge can absorb water in the blood and concentrate blood components, while the existence of conical microchannels can help the sponge to enrich more blood components . Within the prepared taper range, with the increase of the taper of the conical microchannel, the liquid absorbability of the sponge is accelerated, which helps to increase the local concentration of platelets and coagulation factors in the wound, thus shortening the time to trigger the coagulation cascade.…”

Section: Introductionmentioning

confidence: 99%

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Gelatin Methacryloyl-Based Sponge with Designed Conical Microchannels for Rapidly Controlling Hemorrhage and Theoretical Verification

Cao

Zhang

et al. 2023

ACS Biomater. Sci. Eng.

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It remains a challenge to develop effective hemostatic products in battlefield rescue for noncompressible massive hemorrhage. Some previous research had concentrated on the modification of different materials to improve the hemostasis ability of sponges. Herein, to investigate the relationship between the taper of microchannels and hemostatic performance of porous sponges, gelatin methacryloyl-based sponges with designed conical microchannels and a disordered porous structure were prepared using the 3D printing method and freeze-drying technology. Experiments and theoretical model analysis demonstrated that the taper and distribution of microchannels in the sponge affected the water and blood absorption properties, as well as the expansion ability. In treatment of SD rat liver defect and SD rat liver perforation wound, GS-1 sponge with the taper (1/15) microchannels exhibited an excellent hemostatic effect with blood loss of 0.866 ± 0.093 g and a hemostasis time of 280 ± 10 s. Results showed that the hemostatic capacities of GelMA sponges were increased with the bottom diameter (taper) of conical microchannels. This is a potential strategy to develop designed taper sponges with designed taper microchannels for rapidly controlling hemorrhage.

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Section: Preparation Of Different Gelma Spongesmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gelatin Methacryloyl-Based Sponge with Designed Conical Microchannels for Rapidly Controlling Hemorrhage and Theoretical Verification

Cao

Zhang

et al. 2023

ACS Biomater. Sci. Eng.

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“…Naturally derived materials have been increasingly attractive compared to synthetic materials due to their better biocompatibility, biodegradability and low/no toxicity [ 186 , 187 ]. A great range of biopolymers and derivatives have been processed into hemostatic sponges, such as gelatin [ 148 , 188 ], chitosan [ 185 , 189 , 190 ], cellulose [ 154 , 183 ] and alginate [ 191 ].…”

Section: Various Forms Of Hemostat Devices From Biopolymersmentioning

confidence: 99%

Recent advances in biopolymer-based hemostatic materials

Mecwan

Falcone

et al. 2022

Regenerative Biomaterials

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Hemorrhage is the leading cause of trauma-related deaths, in hospital and pre-hospital settings. Hemostasis is a complex mechanism that involves a cascade of clotting factors and proteins that result in the formation of a strong clot. In certain surgical and emergency situations, hemostatic agents are needed to achieve faster blood coagulation to prevent the patient from experiencing a severe hemorrhagic shock. Therefore, it is critical to consider appropriate materials and designs for hemostatic agents. Many materials have been fabricated as hemostatic agents, including synthetic and naturally derived polymers. However, compared to synthetic polymers, natural polymers or biopolymers, which include polysaccharides and polypeptides, have greater biocompatibility, biodegradability, and processibility. Thus, in this review, we focus on biopolymer-based hemostatic agents of different forms, such as powder, particles, sponges, and hydrogels. Finally, we discuss biopolymer-based hemostats currently in clinical trials and offer insight into next-generation hemostats for clinical translation.

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Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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The cross‐linker‐free hydrogels have gained attention due to their lack of need for chemically modified polymers, resulting in better biocompatibility. The hydrogel properties can be enhanced by altering physical forces such as electrostatics and H‐bonds. Tuning the physical interactions between polymers, salts, and plasticisers can unlock new horizons in material properties. This article examines four different salts and mixtures to determine their impact on gelatin‐alginate biomaterial design. Drug release, swelling, and rheological properties are represented using a 3‐D plot, and optimum samples are identified. It is concluded that kosmotropes yield better release and swelling results than chaotropes. The physical interactions of these salts with polymers are explained using DLS and FTIR/ATR studies, and these findings are corroborated with release, swelling, and rheological analyses. Another aspect of the biomaterial, self‐healing property, is also considered. A 3‐D plot is prepared using release kinetics, gel strength, and recovery percentage (three important factors for self‐healing hydrogels). Chaotropes are identified as better candidates for self‐healing behaviour. However, when considering gel strength, release, and self‐healing, kosmotropes are favourable. Hence, different salts can be selected based on the desired application for hydrogels. It is also concluded that electrostatic forces hinder the formation of H‐bonds between polymer chains.

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Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage

Cited by 21 publications

References 53 publications

Gelatin Methacryloyl-Based Sponge with Designed Conical Microchannels for Rapidly Controlling Hemorrhage and Theoretical Verification

Gelatin Methacryloyl-Based Sponge with Designed Conical Microchannels for Rapidly Controlling Hemorrhage and Theoretical Verification

Recent advances in biopolymer-based hemostatic materials

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

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