Polyvinyl alcohol-based electrospun matrix as a delivery system for nanoemulsion containing chalcone against Leishmania (Leishmania) amazonensis

Coelho, Daniela; Veleirinho, Beatriz; Mazzarino, Letícia; Alberti, Thaís; Buzanello, Elizandra Bruschi; Oliveira, Regina Eva; Yunes, Rosendo A.; Moraes, Milene Höehr de; Steindel, Mário; Maraschin, Marcelo

doi:10.1016/j.colsurfb.2020.111390

Cited by 15 publications

(4 citation statements)

References 31 publications

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“…[11] Recently synthetic polymers are also being used as they could provide additional mechanical stability. [12] Lin et al have fabricated nanofibrous mesh of cationic poly(vinyl cyclohexene carbonate) with polyacrylonitrile blend and evaluated for wound healing applications. [13] Therefore, the blend of natural and synthetic polymers is the desired composition of material for wound dressing application.…”

Section: Introductionmentioning

confidence: 99%

An Investigation into the Efficacy of Low Temperature and UV Irradiated Citric Acid Crosslinked Zein/PEO Electrospun Membranes for Wound Healing Using Human Dermal Fibroblast Cells

Medha,

Resmi,

Rekha

et al. 2023

ChemistrySelect

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A key material capable of effective wound closure is a pertinent demand of the day. Citric acid (CA)‐based crosslinking involves pre‐crosslinking followed by post‐crosslinking at higher temperature. Unlike conventional higher temperature treatment, this piece of work discusses post‐crosslinking at low temperature or under UV irradiation of CAZein/Polyethylene oxide (PEO) blend membranes. A comparative analysis of the wound healing efficiency of both membranes was done. Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) results showed that UV crosslinked CA Zein/PEO has a fast thermal degradation and the folded structure of the protein perturbed during UV crosslinking. More than 60 % of porosity and water vapor transmission rate (WVTR) of 1500–2000 g m−2 day−1 for both membranes could facilitate faster exudate absorption and gas exchange through the wound site. Thermally crosslinked CA Zein/PEO stimulated 67 % more collagen production within 2 days compared to control cells. Percentage of wound closure is also high for thermally crosslinked CA Zein/PEO compared to UV crosslinked CA Zein/PEO. Though cytotoxicity evaluation confirmed the non‐cytotoxicity of both membranes, thermally crosslinked membrane proved as a better candidate for wound care management.

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Section: Introductionmentioning

confidence: 99%

An Investigation into the Efficacy of Low Temperature and UV Irradiated Citric Acid Crosslinked Zein/PEO Electrospun Membranes for Wound Healing Using Human Dermal Fibroblast Cells

Medha,

Resmi,

Rekha

et al. 2023

ChemistrySelect

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“…An emulsion system can be made more stable against phase separation when the droplet sizes of the emulsion become smaller (McClements, 2006), as the small sizes make them stable against coalescence and, the coalescence rate occurs more rapidly than the dispersed phase particle fusion and phase separation, which results from the force of the droplet weight. The smaller the size of the nanoemulsion particles, the easier its movement in the nozzle, which is accompanied by high shear force, and the nanoemulsion maintains its stability at the end of the nozzle, where a smaller amount of essential oil evaporates between the nozzle and the collector when leaving the nozzle, resulting in nanofibres with more effective substances (Coelho et al ., 2021).…”

Section: Resultsmentioning

confidence: 99%

Fabrication, characterisation and antimicrobial activity of electrospun Plantago psyllium L. seed gum/gelatine nanofibres incorporated with Cuminum cyminum essential oil nanoemulsion

Mohajeri

Sourki

Nikoo

et al. 2023

Int J of Food Sci Tech

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Summary Plantago psyllium L. seed gum (PPSG)/gelatine nanocomposites containing Cuminum cyminum essential oil (CCEO) were prepared via electrospinning, and the antibacterial properties of the electrospun nanofibres were assessed against Staphylococcus aureus. The nanoemulsion was prepared by adding CCEO to the PPSG/gelatine mixture and sonicated. Uniform nanofibres resulted from the nanoemulsion containing 1.5% PPSG, 8% gelatine and 3% CCEO, and no chemical reactions between the components of the electrospun nanofibres were detected. Growth inhibition zone diameter indicated that the electrospun nanofibres containing at least 3% CCEO had the most significant inhibitory effect on the growth of S. aureus. The electrospun PPSG/gelatine‐CCEO nanocomposites are capable of being used as a biodegradable material in food packaging as well as in edible coatings for the preservation of food products.

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“…The topical application of drugs for CL requires drug penetration within the dermis, where the parasites are internalized into macrophages. Using a polyvinyl alcohol (PVA)-based electrospun mat as chalcone delivery system [95], it was found that the nanosystem allowed mostly retention of the drug in the upper skin layer while the nanoemulsion form penetrated much deeper. In vitro testing using amastigotes of L. amazonensis revealed greater efficiency of parasitic growth inhibition compared with the free forms of the chalcones.…”

Section: Micro/nanofibresmentioning

confidence: 99%

Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

et al. 2022

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Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity.

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Polyvinyl alcohol-based electrospun matrix as a delivery system for nanoemulsion containing chalcone against Leishmania (Leishmania) amazonensis

Cited by 15 publications

References 31 publications

An Investigation into the Efficacy of Low Temperature and UV Irradiated Citric Acid Crosslinked Zein/PEO Electrospun Membranes for Wound Healing Using Human Dermal Fibroblast Cells

An Investigation into the Efficacy of Low Temperature and UV Irradiated Citric Acid Crosslinked Zein/PEO Electrospun Membranes for Wound Healing Using Human Dermal Fibroblast Cells

Fabrication, characterisation and antimicrobial activity of electrospun Plantago psyllium L. seed gum/gelatine nanofibres incorporated with Cuminum cyminum essential oil nanoemulsion

Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

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