Polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins (PF1380 and ExbB) of Pseudomonas fluorescens in fish

Liu, Xiang; Xiao, Huihui; Chao, Jia; Jian, Sijie; Wu, Xiaoqing; Lu, Juan; Wang, Juan; Chen, Chunlin; Liu, Yong

doi:10.1016/j.fsi.2023.109211

Fish & Shellfish Immunology

2023

DOI: 10.1016/j.fsi.2023.109211

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Polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins (PF1380 and ExbB) of Pseudomonas fluorescens in fish

Xiang Liu,

Huihui Xiao,

Jia Chao

et al.

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2024

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Cited by 3 publications

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Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

Elgendy,

Ali,

Dayem

et al. 2024

Aquacult Int

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The aquaculture industry is suffering from significant financial setbacks due to an increasing frequency of disease outbreaks, posing a threat to the sector’s sustainability. Various bacterial, viral, parasitic, and fungal pathogens have led to massive mortalities in farmed fish worldwide. Throughout the years, the management of fish diseases has predominantly centered around the utilization of conventional antibiotics and chemicals. Nevertheless, their indiscriminate use has given rise to serious implications, including an increase in resistant pathogens, disruptions in the metabolic processes of fish, degradation of the aquatic environment, the presence of drug residues in aquatic products, and a potential threat to human health. Various effective bio-based and immunoprophylaxis alternative therapies have been developed to overcome these impediments. Recent alternative therapeutic approaches to fish diseases encompass a range of strategies, including phytotherapeutics, nanotherapeutics, probiotics, prebiotics, synbiotics, phage therapy, vaccination, quorum quenching, antimicrobial peptides, biosurfactants, bacteriocins, stem cells, and diagnostic-based therapy. Advancements in biotechnology have significantly enhanced the efficacy of these therapies. However, additional research is essential to refine the utilization of these therapeutic approaches. Critical concerns, such as efficacy, cost, risks, availability, and adverse effects on fish and the ecosystem, need to be addressed to establish guidelines for their sustainable application in aquaculture. This review will increase aquaculturists’ awareness of recent therapies used in fish farming, their mechanisms, challenges, and impacts while promoting the sustainability of commercial aquaculture.

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Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

Elgendy,

Ali,

Dayem

et al. 2024

Aquacult Int

View full text Add to dashboard Cite

show abstract

Differential polyvalent passive immune protection of egg yolk antibodies (IgY) against live and inactivated Vibrio fluvialis in fish

Liu,

Xiao,

Cui

et al. 2024

Fish & Shellfish Immunology

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A Comparison of Polyvalent Passive Immunoprotection from Antibodies with Different Immunity Models of Live or Inactivated Vibrio fluvialis in Fish

Xiao,

Cui,

Chen

et al. 2024

Fishes

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Polyvalent passive vaccines can act fast in resisting various bacteria with good efficacy, and they have application value in aquaculture. This study prepared live and inactivated Vibrio fluvialis mouse antisera (L-VF-antiserum and I-VF-antiserum), and administered them to goldfish (Carassius auratus) infected with V. fluvialis and Aeromonas hydrophila. The passive protective rates of live and inactivated mouse antisera against V. fluvialis were 60% (p < 0.05) and 40% (p < 0.05), and their passive cross-protective rates against A. hydrophila were 42.86% (p < 0.05) and 35.71% (p < 0.05), respectively. Furthermore, the two mouse antisera could recognize the bacteria in vitro; the content of bacteria in the C. auratus kidney decreased (p < 0.05), the phagocytic activity of C. auratus leukocytes was enhanced (p < 0.05), and the expression of inflammatory genes and activity of antioxidant factors decreased (p < 0.05). Moreover, the kidney, spleen, and intestinal tissue structures were intact, and the apoptosis and DNA damage were decreased (p < 0.05) among the kidney cells. The live V. fluvialis antiserum contained more antibodies against the outer membrane proteins of V. fluvialis than the inactivated mouse antiserum. The immunoprotective abilities of the live V. fluvialis antiserum were higher than those of the inactivated antiserum, and the antiserum of live V. fluvialis immunity demonstrated potential application value as a polyvalent passive immune vaccine in fish.

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Polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins (PF1380 and ExbB) of Pseudomonas fluorescens in fish

Cited by 3 publications

References 52 publications

Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

Differential polyvalent passive immune protection of egg yolk antibodies (IgY) against live and inactivated Vibrio fluvialis in fish

A Comparison of Polyvalent Passive Immunoprotection from Antibodies with Different Immunity Models of Live or Inactivated Vibrio fluvialis in Fish

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