Polyvalent Aptamer-Functionalized NIR-II Quantum Dots for Targeted Theranostics in High PD-L1-Expressing Tumors
Xin Huang,
Jiawei Zhu,
Chuhuang Dong
et al.
Abstract:Ag 2 S quantum dots (QDs) show superior optical properties in the NIR-II region and display significant clinical potential with favorable biocompatibility. However, inherent defects of low targeting and poor solubility necessitate practical modification methods to achieve the theranostics of Ag 2 S QDs. Herein, we used rolling circle amplification (RCA) techniques to obtain long single-stranded DNA containing the PD-L1 aptamer and C-rich DNA palindromic sequence. The C-rich DNA palindromic sequences can specif… Show more
“…Such targeted binding enhances imaging selectivity and accuracy, minimizing effects on normal tissues. 33 This approach enables efficient labeling of antibodies and enzymes labeled with biotin without compromising their activity.…”
Quantum dots (QDs), with their unique optical and physical properties, have revolutionized the field of biological imaging, providing researchers with tools to explore cellular processes and molecular interactions in unprecedented detail.
“…Such targeted binding enhances imaging selectivity and accuracy, minimizing effects on normal tissues. 33 This approach enables efficient labeling of antibodies and enzymes labeled with biotin without compromising their activity.…”
Quantum dots (QDs), with their unique optical and physical properties, have revolutionized the field of biological imaging, providing researchers with tools to explore cellular processes and molecular interactions in unprecedented detail.
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