Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) &amp; Type 2 Diabetes Mellitus (DM)

Shin, Hyun Jong; Kim, Jae Ha; Yi, Joo-Hark; Han, Sang-Woong; Kim, Ho Jung

doi:10.5049/ebp.2012.10.1.26

Cited by 19 publications

(14 citation statements)

References 11 publications

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“…However, an interesting first case of coexistence of CDI and type 2 DM has been reported in a 56-year-old man though no common cause could be determined. [ 30 ]…”

Section: T Ypes Of D Iabetes I mentioning

confidence: 99%

Diabetes insipidus: The other diabetes

Kalra¹,

Zargar²,

Jain³

et al. 2016

Indian J Endocr Metab

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Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin.

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“…However, an interesting first case of coexistence of CDI and type 2 DM has been reported in a 56-year-old man though no common cause could be determined. [ 30 ]…”

Section: T Ypes Of D Iabetes I mentioning

confidence: 99%

Diabetes insipidus: The other diabetes

Kalra¹,

Zargar²,

Jain³

et al. 2016

Indian J Endocr Metab

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show abstract

“…Diabetes mellitus may present with classical characteristic features such as blurring of vision, excessive thirst (polydypsia), excessive feeding (polyphagia) excessive urination (polyuria), and weight loss. In its most severe forms, ketoacidosis may develop leading to stupor, coma and, in absence of effective treatment death ensues [2].…”

Section: General Overview Of Diabetic Mellitusmentioning

confidence: 99%

Some Selected Medicinal Plants with Antidiabetic Potentials

Oyagbemi¹,

Salihu²,

Oguntibeju³

et al. 2014

Antioxidant-Antidiabetic Agents and Human Health

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“…However, we did not rule out central diabetes insipidus. Previous studies have reported cases of central diabetes insipidus during diabetic ketoacidosis (14,15). In our case, the patient did not demonstrate hyponatremia or hypercalcemia leading to nephrogenic diabetes insipidus.…”

Section: Discussionmentioning

confidence: 99%

Euglycemic Diabetic Ketoacidosis with Persistent Diuresis Treated with Canagliflozin

2017

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Diabetic ketoacidosis is characterized by hyperglycemia, anion-gap acidosis, and increased plasma ketones. After the resolution of hyperglycemia, persistent diuresis is rare. We herein report the case of a 27-year-old Asian woman with type 2 diabetes who was treated with a sodium-glucose cotransporter 2 (SGLT2) inhibitor (canagliflozin) who developed euglycemic diabetic ketoacidosis and persistent diuresis in the absence of hyperglycemia. Physicians should consider euglycemic diabetic ketoacidosis in the differential diagnosis of patients treated with SGLT2 inhibitors.

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Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM)

Cited by 19 publications

References 11 publications

Diabetes insipidus: The other diabetes

Diabetes insipidus: The other diabetes

Some Selected Medicinal Plants with Antidiabetic Potentials

Euglycemic Diabetic Ketoacidosis with Persistent Diuresis Treated with Canagliflozin

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