Polyuria during experimental modifications of breathing

Currie, Jon; Ullmann, Elisabeth

doi:10.1113/jphysiol.1961.sp006638

Cited by 17 publications

(8 citation statements)

References 13 publications

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“…Interpretation is complicated by the accident that resting urine flow before anoxia was different in the two sets of experiments. The possible reasons for the increase in urinary volume in these experiments will be much more extensively discussed in the following paper (Currie & Ullmann, 1961) in connexion with the observation that urine flow may rise in any circumstance involving alteration of respiration, even in the absence of anoxia or hypocapnia. The experiments described in the present paper indicated that something other than hypocapnia may act to augment diuresis.…”

Section: Elisabeth Ullmannmentioning

confidence: 95%

Acute anoxia and the excretion of water and electrolyte

Ullmann¹

1961

The Journal of Physiology

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Section: Elisabeth Ullmannmentioning

confidence: 95%

Acute anoxia and the excretion of water and electrolyte

Ullmann¹

1961

The Journal of Physiology

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“…In humans, voluntary normoxic isocapnic hyperventilation at rest (>30 L/min) causes diuresis and natriuresis [ 181 ]. However, hypoxic hyperventilation in normal resting subjects does not usually exceed 10-15 L/min at least above 10 % O 2 [ 64 ], and diuresis and natriuresis occur in animals with fi xed ventilation [ 60 ].…”

Section: Cardiopulmonary Innervationmentioning

confidence: 98%

Renal Function and Fluid Homeostasis

Swenson

Olsen

2013

High Altitude

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Hypoxia can directly affect the kidneys, but more importantly, its effects on systemic acid-base balance, ventilation, neuroendocrine refl exes, and hemodynamics all play a far greater part in altering renal function and fl uid balance. Acute and chronic effects of hypoxia and their magnitude may differ and these will be highlighted. These changes will be related to the common diseases of high altitude and to their impact on patients with chronic renal disease. Other features of high altitude separate from hypoxia, either alone or in combination, including hypobaria, exercise, and cold may also signifi cantly perturb renal function.

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“…In normal human volunteers and experimental animals, induction of hypoxia has been reported to result in increased (6)(7)(8)(9)(10)(11)(12), decreased (6,(13)(14)(15), and unchanged (16) urine flow. This variability ofthe effect of hypoxia on urine flow may be related to differences in the degree ofhypoxia, in the magnitude ofassociated renal hemodynamic alterations (7,(17)(18)(19)(20)(21)(22), in the variable effects of hypoxia on solute excretion (3,(8)(9)(10)14), or in associated abnormalities in arterial pH and pressure of carbon dioxide (PCO2) (10,11).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Effect of Hypoxia on Renal Water Excretion

Anderson¹,

Pluss²,

Berns³

et al. 1978

J. Clin. Invest.

104

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A B S T R A C T The effect of lowering the pressure of oxygen from 80 to 34 mm Hg was examined in anesthetized dogs that were undergoing a water diuresis. This degree of hypoxia was associated with an antidiuresis as urine osmolality (Uosm) increased from 107 to 316 mosmol/kg H20 (P < 0.001) and plasma arginine vasopressin increased from 0.06 to 7.5 pLU/ml, (P < 0.05).However, hypoxia was not associated with significant changes in cardiac output (CO, from 4.2 to 4.7 liters/ min), mean arterial pressure (MAP, from 143 to 149 mm Hg), glomerular filtration rate (GFR, from 46 to 42 ml/min), solute excretion rate (SV, from 302 to 297 mosmol/min), or filtration fraction (from 0.26 to 0.27, NS). Hypoxia was associated with an increase in renal vascular resistance (from 0.49 to 0.58 mm Hg/ml per min, P < 0.01). The magnitude of hypoxia-induced antidiuresis was the same in innervated kidneys and denervated kidneys. To further examine the role of vasopressin in this antidiuresis, hypoxia was induced in hypophysectomized animals. The effect of hypoxia on CO, MAP, GFR, SV, and renal blood flow in hypophysectomized animals was the same as in intact animals. In contrast to intact animals, however, hypoxia did not induce a significant antidiuresis in hypophysectomized animals (Uosm from 72 to 82 mosmol/kg H2O). To delineate the afferent pathway for hypoxiastimulated vasopressin release, hypoxia was induced in dogs with either chemo-or baroreceptor denervation. The effect of hypoxia on CO, MAP, GFR, SV, and renal blood flow in the denervated animals was the same as in nondenervated animals. Hypoxia resulted in an antidiuresis in chemoreceptor (Uosm from 113 to 357 mosmol/kg H20, P < 0.001) but not in baroreceptor (Uosm from 116 to 138 mosmol/kg H20, NS) denervated animals. To determine if hypoxia alters renal response to vasopressin, exogenous vasopressin was adminisDr.

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Polyuria during experimental modifications of breathing

Cited by 17 publications

References 13 publications

Acute anoxia and the excretion of water and electrolyte

Acute anoxia and the excretion of water and electrolyte

Renal Function and Fluid Homeostasis

Mechanism of Effect of Hypoxia on Renal Water Excretion

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