Polyurethanes for Medical Use

Pivec, Tanja; Smole, Majda Sfiligoj; Gašparič, Petra; Stana‐Kleinschek, Karin

doi:10.14502/tekstilec2017.60.182-197

Cited by 21 publications

(8 citation statements)

References 70 publications

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“…The main applications of PU, still in continuous development, are as thermal insulations, different automotive components, elastic mattresses, adhesives, etc. Their suitability as biomedical materials started to be investigated a few decades ago by Boretos and Pierce [ 29 ], who reported their vascular acceptability in experimental heart-assist pump chambers and continued with the design and production of various cardiovascular, obstetrics and gynecology devices, reconstructive surgery materials, and more [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

et al. 2020

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The Herpes simplex viruses (HSV-1, HSV-2) are responsible for a wide variety of conditions, from cutaneous-mucosal to central nervous system (CNS) infections and occasional infections of the visceral organs, some of them with a lethal end. Acyclovir is often used intravenously, orally, or locally to treat herpetic infections but it must be administered with caution to patients with kidney disease and to children of early age. The main objectives of this study were to synthesize and evaluate new polyurethane nanoparticles that might be used as proper transmembrane carriers for acyclovir. Polyurethane particles were obtained by a polyaddition process: a mixture of two aliphatic diisocyanates used as organic phase was added to a mixture of butanediol and polyethylene glycol used as aqueous phase. Two different samples (with and without acyclovir, respectively) were synthesized and characterized by UV-Vis spectra in order to assess the encapsulation efficacy and the release profile, FT-IR, DSC, SEM, and SANS for structural characterization, as well as skin irritation tests. Nearly homogeneous samples with particle sizes between 78 and 91 nm have been prepared and characterized revealing a medium tendency to form clusters and a high resistance to heat up to 300 °C. The release profile of these nanoparticles is characteristic to a drug delivery system with a late discharge of the loaded active agents. Very slight increases in the level of transepidermal water loss and erythema were found in a 15-day evaluation on human skin. The results suggest the synthesis of a non-irritative carrier with a high encapsulation efficacy that can be successfully used for the transmembrane transfer of acyclovir.

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Section: Discussionmentioning

confidence: 99%

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

et al. 2020

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“…A significant share of the polyurethane degradation research approaches this topic from a different angle, because polyurethanes have lots of medical applications like in wound dressings, tissue engineering scaffolds, implants and drug delivery with nanoparticles and nanocapsules. For some of those usages degradability of material is a disadvantage [ 87 , 88 , 89 , 97 ], for others, it has to be possible to strictly control the moment and way of degradation [ 91 , 106 ]. Moreover, degradation products are of high importance due to their possible toxicity on cells surrounding applied biomaterial [ 98 ].…”

Section: Polyurethane Waste Managementmentioning

confidence: 99%

Polyurethane Recycling and Disposal: Methods and Prospects

2020

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Growing water and land pollution, the possibility of exhaustion of raw materials and resistance of plastics to physical and chemical factors results in increasing importance of synthetic polymers waste recycling, recovery and environmentally friendly ways of disposal. Polyurethanes (PU) are a family of versatile synthetic polymers with highly diverse applications. They are class of polymers derived from the condensation of polyisocyanates and polyalcohols. This paper reports the latest developments in the field of polyurethane disposal, recycling and recovery. Various methods tested and applied in recent years have proven that the processing of PU waste can be economically and ecologically beneficial. At the moment mechanical recycling and glycolysis are the most important ones. Polyurethanes’ biological degradation is highly promising for both post-consumer and postproduction waste. It can also be applied in bioremediation of water and soil contaminated with polyurethanes. Another possibility for biological methods is the synthesis of PU materials sensitive to biological degradation. In conclusion, a high diversity of polyurethane waste types and derivation results in demand for a wide range of methods of processing. Furthermore, already existing ones appear to be enough to state that the elimination of not reprocessed polyurethane waste in the future is possible.

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“…The fabricated composite could accelerate wound healing and reduce the formation of scars [280]. PU compositions are selected for wound healing applications based on their chemical composition, shape, and functionalization [7,281]. Transparent and thin PU films are primarily suitable for surface protection and wounds after an operation with less or no exudate secretion.…”

Section: Pus For Wound Healingmentioning

confidence: 99%

“…PU is a broad category of polymers [5] containing urethane groups formed in the reaction between isocyanate (NCO) and alcohol (-OH) [6]. PU has a complex chemical structure that includes a polyol, a diisocyanate, and a chain extender [7]. PU contains other groups depending on the chemical composition, such as urea, esters, ethers, carbonates, and aromatic components [6].…”

Section: Introductionmentioning

confidence: 99%

Updates on polyurethane and its multifunctional applications in biomedical engineering

Miri,

Farè,

et al. 2023

Prog. Biomed. Eng.

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Polyurethanes (PU) have properties that make them promising in biomedical applications. PU is recognized as one of the main families of blood and biocompatible materials. PU plays a vital role in the design of medical devices in various medical fields. The structure of PU contains two segments: soft and hard. Its elastomeric feature is due to its soft segment, and its excellent and high mechanical property is because of its hard segment. It is possible to achieve specific desirable and targeted properties by changing the soft and hard chemical structures and the ratio between them. The many properties of PU each draw the attention of different medical fields. This work reviews PU highlighted properties, such as biodegradability, biostability, shape memory, and improved antibacterial activity. Also, because PU has a variety of applications, this review restricts its focus to PU’s prominent applications in tissue engineering (TE), cardiovascular medicine, drug delivery, and wound healing. In addition, it contains a brief review of PU’s applications in biosensors and oral administration.

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Polyurethanes for Medical Use

Cited by 21 publications

References 70 publications

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

Polyurethane Recycling and Disposal: Methods and Prospects

Updates on polyurethane and its multifunctional applications in biomedical engineering

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