Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research

Niimi, Yosuke; Fukuda, Seisuke; Alharbi, Suzan; Prough, Donald S.; Enkhbaatar, Perenlei

doi:10.1016/j.reth.2020.04.007

Cited by 13 publications

(4 citation statements)

References 12 publications

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“…45,46 Other studies have shown minerals such as calcium in sea buckthorn are effective in speeding up the wound healing process. 47,48 Several pieces of research have been done on the efficacy of the sea buckthorn dressing on wounds of non-human samples 49,50 ; even though the results should be viewed with caution, the findings of these studies report the quality of sea buckthorn in facilitating and accelerating the wound healing process. 51,52 The findings of these kinds of studies can prove the results of our study implying the better quality of sea buckthorn dressing cream in healing second-degree burns compared to 1% SSD dressing.…”

Section: Discussionmentioning

confidence: 99%

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

Abdullahzadeh

Shafiee

2021

Wound Repair Regeneration

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Burn injuries can be associated with the incidence of disability and death, yet their management remains a costly difficult problem. We conducted this clinical trial to evaluate the period of wound healing with sea buckthorn dressings for the seconddegree burns and compare the results with 1% silver sulfadiazine (SSD) dressings. This randomized triple-blind clinical trial was conducted in a hospital in Isfahan, Iran.Fifty-five patients suffering second-degree burns were recruited through convenient sampling and randomly divided into two groups and treated with either sea buckthorn cream or 1% SSD. Wound dressings were done until complete wound healing was attained. The process of healing burns was monitored using the Bates-Jensen Wound Assessment Tool; complete healing was determined by using the standard burn healing checklist. It was deduced that the period of healing second-degree burns in the group treated with sea buckthorn cream was shorter than the group treated with 1% SSD (p < 0.001). The results demonstrated the greater clinical efficacy of sea buckthorn cream over 1% SSD for healing second-degree burns. It was concluded that using sea buckthorn dressing by reducing the period of wound healing can shorten the course of treatment of second-degree burns as well as reduce the burden of care in health care services.

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Section: Discussionmentioning

confidence: 99%

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

Abdullahzadeh

Shafiee

2021

Wound Repair Regeneration

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“…Sheep, in which the current CMAP measurement method was established, have been widely used as a translational animal model in studies of intensive care [ 15 ] and wound healing [ 16 ]. The advantages of using sheep as an experimental model include (a) their anatomical and pathophysiological similarities to humans, and (b) their calm nature compared to other large animals commonly used as experimental models, such as pigs, enabling easier postoperative wound management.…”

Section: Discussionmentioning

confidence: 99%

An electrophysiological evaluation method for the ovine facial nerve

Matsumine¹,

Niimi²,

Matsumine³

2021

Regenerative Therapy

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Introduction Large-animal models such as sheep for facial nerve regeneration research have not yet been established because of the lack of methods for assessing the electrophysiological function of regenerated nerves. In this study, we developed a percutaneous measurement method for the evoked compound muscle action potential (CMAP) of the facial nerve in sheep. Methods Six 3-year-old castrated male Corriedale sheep were used in this study. Under general anesthesia, an anatomical exploration was performed to identify the course of the buccal branch of the facial nerve and its innervating muscles on one side, followed by the application of surface stimulating electrodes to the contralateral side of the face along the course of the buccal branch of the facial nerve to obtain CMAP measurements of the nasolabial levator muscle. Results Percutaneous CMAP measurements of the nasolabial levator muscle could be obtained in all animals by placing stimulating electrodes 1 cm apart on the line coinciding with the course of the buccal branch of the facial nerve revealed by the preceding anatomical exploration. Mean values for electrophysiological parameters were amplitude 4.7 ± 0.7 mV, duration 2.1 ± 0.6 ms, and latency 3.6 ± 0.4 ms. Conclusion We have established a percutaneous measurement method for CMAP of the buccal branch of the facial nerve in sheep. This method is expected to be very useful in future studies of facial nerve regeneration for long nerve defects in sheep.

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“…Stem cells, biomaterial scaffolds, bioactive factors, etc. have been used to promote the regeneration of skin ( Chen et al, 2020 ; Niimi et al, 2020 ; Tottoli et al, 2020 ). Extracellular vesicle-based therapeutics have shown promise in preclinical and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing

Zhu

Zhang

Hao

et al. 2022

Front. Cell. Neurosci.

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Wound repair is a key step in the treatment of skin injury caused by burn, surgery, and trauma. Various stem cells have been proven to promote wound healing and skin regeneration as candidate seed cells. Therefore, exosomes derived from stem cells are emerging as a promising method for wound repair. However, the mechanism by which exosomes promote wound repair is still unclear. In this study, we reported that exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) promote wound healing and skin regeneration by treating cutaneous nerve damage. The results revealed that UC-MSCs exosomes (UC-MSC-Exo) promote the growth and migration of dermal fibroblast cells. In in vitro culture, dermal fibroblasts could promote to nerve cells and secrete nerve growth factors when stimulated by exosomes. During the repair process UC-MSC-Exo accelerated the recruitment of fibroblasts at the site of trauma and significantly enhanced cutaneous nerve regeneration in vivo. Interestingly, it was found that UC-MSC-Exo could promote wound healing and skin regeneration by recruiting fibroblasts, stimulating them to secrete nerve growth factors (NGFs) and promoting skin nerve regeneration. Therefore, we concluded that UC-MSC-Exo promote cutaneous nerve repair, which may play an important role in wound repair and skin regeneration.

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Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research

Cited by 13 publications

References 12 publications

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

An electrophysiological evaluation method for the ovine facial nerve

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing

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