Polyurethane Coating in the Prevention of Nickel Dermatitis

Moseley, John C.

doi:10.1001/archderm.1971.04000130060008

Cited by 17 publications

(4 citation statements)

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“…The advantage of cation exchange resins in comparison to ligands is their inability to absorb through the skin. A polyurethane coating of consumer items worn close to the skin (e.g., jean buttons, bracelets, and watches) may prevent nickel dermatitis in nickel-allergic individuals , Finally, a randomized, double-blind study found that a 10% diethylenetriaminepentaacetic acid (DTPA) cream abrogated positive patch test reactions in nickel-, cobalt-, and copper-sensitized subjects but not in palladium- and chromium-allergic patients .…”

Section: Discussionmentioning

confidence: 99%

Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

Thyssen

Menné

2009

Chem. Res. Toxicol.

343

243

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The prevalence of metal allergy is high in the general population, and it is estimated that up to 17% of women and 3% of men are allergic to nickel and that 1-3% are allergic to cobalt and chromium. Among dermatitis patients, the prevalence of metal allergy is even higher. Metal allergy is mainly an environmental disorder although null mutations in the filaggrin gene complex were recently found to be associated with nickel allergy and dermatitis. Environmental metal exposures include jewelry, buttons, clothing fasteners, dental restorations, mobile phones, and leather. Although consumer exposure is responsible for most cases of metal allergy, the importance of occupational metal exposure remains present and should always be taken into consideration when one interprets allergic patch test reactions to metals. Traditionally, nickel, cobalt, and chromium have been the most important contact allergens. However, recently, gold and palladium have drawn much attention as the prevalence of contact allergy to these metals is high. Palladium allergy is mainly a result of cross-sensitization to nickel, whereas gold allergy is rarely clinically relevant when one takes its high prevalence into account. The epidemiology of metal allergy has recently changed in Europe as nickel allergy among ear-pierced Danish women has decreased following regulatory intervention on nickel release from consumer products. In the United States, the prevalence of nickel allergy is still increasing, which may be explained by the absence of regulation. The prevalence of chromium allergy is increasing in the United States, Singapore, and Denmark among dermatitis patients. This increase is significantly associated with leather exposure in Denmark. Metal allergy may result in allergic contact dermatitis and systemic allergic (contact) dermatitis. Furthermore, metal allergy has been associated with device failure following insertion of intracoronary stents, hip and knee prostheses, as well as other implants. This area is in need of more research.

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Section: Discussionmentioning

confidence: 99%

Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

Thyssen

Menné

2009

Chem. Res. Toxicol.

343

243

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“…Concerning preventive measures, rubber gloves result inefficient, as metal ions are able to penetrate through them [45]. Polyurethane coating of metal items [46], as well as barrier creams containing sodium ethylendiaminetetraacetate (EDTA) demonstrate usefulness in protecting from nickel contact [47]. Nonetheless, not every chelating agent has been shown to efficacy prevent nickel contact allergy (e.g.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Allergic Contact Dermatitis to Nickel: From Clinical Aspects to Therapeutic Measures

Bonamonte¹,

Guida²,

Vestita³

et al. 2015

CIEMD

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Nickel is the major cause of allergic contact dermatitis. It is a widely spread metal, being therefore very difficult to avoid. Nickel cutaneous allergy can occur in occupational and non-occupational contexts and can result from direct cutaneous contact, systemic as well as airborne exposure. Such allergy can manifest with typical lesions of allergic contact dermatitis or with peculiar features such as follicular erythemato-micropapularvescicular lesions. Diagnosis of allergic contact dermatitis to nickel is based on patch testing, employing nickel sulfate 5% in petroleum jelly. Reactions to patch test have to be assessed at 48-72 hours, and up to 6 days. Nickel contact dermatitis can be managed with the traditional therapeutic approach used in allergic contact dermatitis. As of today, hyposensitization therapy with oral nickel represents to be the only treatment acting on the pathogenetic mechanisms of nickel allergy.

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“…Rubber gloves are inefficient for prevention of nickel contact, as metal ions penetrate through them 65 . Polyurethane coating of metal items can be beneficial in protection from nickel contact, 66 as are barrier creams contacting sodium EDTA 67 . However, the use of barrier creams is limited as not all chelating agents showed efficacy in preventing nickel contact allergy, namely diethyldithiocarbamate 68…”

Section: Treatment and Prevention Of Nickel Allergymentioning

confidence: 99%

The many faces of nickel allergy

Darlenski

Kazandjieva²,

Pramatarov

2012

Int J Dermatology

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Hypersensitivity reactions to nickel are one of the most common in the modern world. Nickel allergy prevalence is constantly growing in many countries and represents a major health and socioeconomic issue. Herein the current understanding on nickel allergy is summarized with a practical approach to the dermatologist, allergist, and general practitioner. The personal experience with some practical clinical cases of nickel dermatitis is shared. A special emphasis is put on the possible strategies for treatment and prevention of the disease.

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Polyurethane Coating in the Prevention of Nickel Dermatitis

Cited by 17 publications

References 1 publication

Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

Allergic Contact Dermatitis to Nickel: From Clinical Aspects to Therapeutic Measures

The many faces of nickel allergy

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