Polyurethane as Carriers of Antituberculosis Drugs

Batyrbekov, Yerkesh; Iskakov, Rinat

doi:10.5772/35896

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…High values were found in the tested samples for the of dCMP encapsulation efficacy (between 67 and 69%); this parameter plays a major role in the design of drug delivery systems, and it depends on the microencapsulation technique, the solubility of raw materials, the particle size, and the yield of the synthesis reaction. Another investigation on a PU carrier has revealed values of the encapsulation efficacy in a broad range between 55 and 85% [60], while Y. Batyrbekov and R. Iskakov [61] reported an even wider range for the values of entrapment efficiency of PU delivery systems (40-91%). The different structure of the isocyanates that were used as raw materials seems to not have an influence on the encapsulation efficacy, and this can be explained by the similarity of the particle sizes on the one hand and by the same synthesis procedure on the other hand, with both parameters being mentioned in the literature [62].…”

Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

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The delivery of nucleosides represents an interesting research trend in recent years due to their application in various viral infections. The main aims of this study were to develop and to characterize polyurethane particles that are intended to be used for the transport of nucleosides. Three samples have been prepared using aliphatic diisocyanates, a mixture of polyethylene glycol, polycaprolactone, and diols, respectively. The samples were characterized through refractivity measurements, drug loading efficacy, release and penetration rate investigations, FTIR and Raman spectroscopy, thermal analyses, Zetasizer, SEM, HDFa cells viability, and irritation tests on mice skin. The results indicate the obtaining of particles with sizes between 132 and 190 nm, positive Zeta potential values (28.3–31.5 mV), and a refractivity index around 1.60. A good thermal stability was found, and SEM images show a medium tendency to agglomerate. The samples’ color, pH, and electrical conductivity have changed only to a small extent over time, and the evaluations indicate an almost 70% encapsulation efficacy, a prolonged release, and that around 70% of particles have penetrated an artificial membrane in the first 24 h. The synthesized products should be tested in further clinical trials, and the current tests on cell cultures and mice skin revealed no side effects.

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Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

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“…The development of polyurethanes has drawn interest to a large extent in the past few years due to its outstanding physical, thermal and mechanical properties. 11 Therefore, polyurethane with excellent properties and biocompatibility has extensively been used in biomedical devices. PEGylated polyurethanes endow the vehicles with a higher stability.…”

Section: Introductionmentioning

confidence: 99%

Development of pH sensitive polyurethane–alginate nanoparticles for safe and efficient oral insulin delivery in animal models

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

Borcan¹,

Vlase²,

Popescu³

et al. 2023

Preprint

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The drug delivery systems receive more and more attention for the control and treatment of many diseases due to their increased number in recent years. The main aims of this study were to develop and to characterize a polyurethane drug delivery system that it is intended to be used for the transmembrane transport of nucleosides. Three different samples have been synthesized based on aliphatic diisocyanates (hexamethylene diisocyanate, isophorone diisocyanate and lysine diisocyanate) as organic phase, respectively a mixture of polyethylene glycol, polycaprolactone diol and low molecular weight diols as aqueous phase. The samples were characterized by pH, refractivity index and solubility measurements, drug loading efficacy and release investigations, thermal behavior, Zetasizer, cells viability and irritation tests on mice skin. The results indicate the obtaining of different populations of neutral acido-basic particles with size between 132 and 190 nm; the Zeta potential values and SEM images show a medium tendency to form clusters, while UV-Vis evaluations indicate an almost 70% encapsulation efficacy, a prolonged release (45% of encapsulated substance is released in the first 5 days) and around 70% of particles have penetrated an artificial membrane in the first 24h. The synthesized products can be tested in further clinical trials, the currently tests on cells culture and mice skin revealing no side effects.

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Polyurethane as Carriers of Antituberculosis Drugs

Cited by 5 publications

References 42 publications

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Development of pH sensitive polyurethane–alginate nanoparticles for safe and efficient oral insulin delivery in animal models

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

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