Polyunsaturated fatty acids regulate lipogenic and peroxisomal gene expression by independent mechanisms

Clarke, Steven D.; Turini, Marco; Jump, Donald Β.

doi:10.1016/s0952-3278(97)90494-4

Cited by 65 publications

(37 citation statements)

References 18 publications

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“…Whether these hepatic changes in fatty acid concentrations and fatty acid pattern in turn alter gene expression of target genes remains to be determined. A key protein activated by PUFA serving as a ligand is the peroxisomal proliferator receptor a (PPAR-a), which in turn regulates together with retinoid X receptors (RXR) numerous hepatic genes encoding peroxisomal, microsomal and some mitochondrial fatty acid metabolizing enzymes as well as the fatty acid binding protein and fatty acid transporter (Jump et al, 1995;Peters, 1996;Clarke and Jump, 1997;Barclay et al, 1999;Motojima, 2000;Latruffe et al, 2000). Although mice lacking a functional PPAR-a have no obvious phenotype on a normal diet, the animals accumulate massive amounts of lipid in livers when fasted or fed a high-fat diet (Kersten et al, 1999;Hashimoto et al, 2000).…”

Section: From Fatty Acids To Oxidative Stressmentioning

confidence: 99%

Nutrient-gene interactions: a single nutrient and hundreds of target genes

Daniel¹,

Dieck²

2004

Biological Chemistry

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Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.

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Section: From Fatty Acids To Oxidative Stressmentioning

confidence: 99%

Nutrient-gene interactions: a single nutrient and hundreds of target genes

Daniel¹,

Dieck²

2004

Biological Chemistry

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“…9 Fish oils which are rich in n-3 PUFAs have been postulated to be beneficial in several disease states including atherosclerosis, hypertension and arthritis. 11,12 The major n-3 FAs found in fish oil are EPA [20:5 (n-3)] and DHA (22:6, n-3). Fish oils have been shown to reduce hepatic lipogenesis and VLDL secretion and increase post-heparin plasma LPL activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of n–3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats

Popović¹,

Borozan²,

Arsić³

et al. 2011

Croat. Chem. Acta

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Abstract. The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-γ linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)

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“…Therefore among long chain n-3 PUFAs, EPA may produce favourable effects on triglyceride and HDL cholesterol concentrations [67,68]. The hypotriglyceridaemic effect of long chain n-3 PUFAs, mediated by several mechanisms such as enhanced hepatic fatty acid oxidation [69], inhibition of fatty acid and triglyceride synthesis, reduced assembly and secretion of VLDL triglyceride concentrations [70], facilitates triglyceride rich lipoprotein removal through enhanced LPL activity in plasma [71]. Significant increases in HDL have been observed after DHA supplementation [67,68,72,73]; it may be related to decreased cholesteryl ester transfer protein activity that reduces the exchange from HDL cholesterol ester and VLDL, resulting in larger, more cholesterol-rich HDL cholesterol particles [74,75].…”

Section: N-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%