Polyunsaturated Fatty Acids, Microflora and Colitis

Dietary patterns and risk of ulcerative colitis: a case–control study

“…The protective effects of vegetables and fruits consumption against UC might be related to the prebiotic content of these food items, which increase the number of probiotics in the gut . Moreover, when these food items were associated with fish intake in the healthy dietary pattern, their protective effects increased as a result of the added beneficial effects of n ‐3 fatty acids on gut microbiota and mucosal inflammation . By contrast, the effects of the unhealthy diet on increasing the risk of UC might be at least partially attributed to the role of this diet on gut microbiota modulation toward promoting colonisation and proliferation of pathogenic bacteria .…”

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

“…Dietary factors are strong predictors of the gut microbiota composition (49)(50)(51). In fact, it has been projected that dietary factors play a more important role in shaping the gut microbiota composition than do genetic factors (52).…”

Healthy Eating Index‐2015 as a predictor of ulcerative colitis risk in a case–control cohort

“…Conversely, the literature is somewhat fragmented in interpreting the role of PUFA in IBD pathogenesis, with studies demonstrating that they have either protective or predisposing effects . However, this appears to be due primarily to the starkly differential effects of PUFA subgroups, such as n‐3 and n‐6 PUFA, which seem to reduce and increase risk, respectively . This effect is likely to be mediated primarily by the effects of such fatty acids on inflammation, as the inflammatory potential of diet has been shown previously to impact substantially on the rate of UC .…”