Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children

Fatty Acid Supply in Pregnant Women with Type 1 Diabetes Mellitus

“…Some studies found significantly higher LA values in diabetic patients (Decsi et al, 2002Tilvis & Miettinen, 1985), while others found no significant differences (Ruiz-Gutierrez et al, 1993;Seigneur et al, 1994). On the other hand, most studies report significantly lower AA (Decsi et al, 2002;Ruiz-Gutierrez et al, 1993) and DHA values (Decsi et al, 2002;Ruiz-Gutierrez et al, 1993;Tilvis & Miettinen, 1985) in diabetic patients than in controls. In one study (Tilvis et al, 1986), diabetic patients treated with continuous insulin infusion therapy had significantly lower LA, and significantly higher AA and DHA values both in plasma and erythrocyte membrane lipids than patients with conventional insulin therapy.…”

“…LCPUFAs are precursors of different eicosanoids, and their availability may be disturbed in several diseases. As insulin is one of the most potent activators of -6 desaturase enzyme, type 1 diabetes mellitus (T1DM) is characterised by the diminished levels of n-3 LCPUFAs (Decsi et al, 2002Szabó et al, 2010b).…”

Inhibition of Cytokine Signaling in Human Retinal Endothelial Cells through Downregulation of Sphingomyelinases by Docosahexaenoic Acid

“…2 for review). DHA is decreased in the plasma of children with diabetes 3 and in the retinas of diabetic eyes. 4 Recent data showed a beneficial effect of dietary DHA in reducing pathologic retinal angiogenesis, thus preventing the development of oxygen-induced retinopathy.…”

Prevention strategies for type 1 diabetes

“…Similarly, children born to women from Norwegian fishing villages had a significantly decreased risk of getting diabetes compared with children of women who lived in cities away from the coast [25]. It is also known that children with diabetes have significantly lower levels of DHA and lower n-3/n-6 ratios than do control children [26].…”