Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer

Michalak, Arkadiusz; Mosińska, Paula; Fichna, Jakub

doi:10.3389/fphar.2016.00459

Cited by 76 publications

(72 citation statements)

References 129 publications

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“…Lipids are becoming increasingly recognized as playing an important role in gut inflammation and interacting with the microbiota (29, 71–74). Interventions focused on the addition of lipids as dietary supplements or modulating the host response in other gut inflammatory diseases, are especially promising and could potentially be useful in NEC (75–77). …”

Section: Proteomics and Metabolomics Applied To Necmentioning

confidence: 99%

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Rusconi

Good

Warner

2017

The Journal of Pediatrics

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Section: Proteomics and Metabolomics Applied To Necmentioning

confidence: 99%

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Rusconi

Good

Warner

2017

The Journal of Pediatrics

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“…Fiber has long been recommended for the management of various gastrointestinal (GI) ailments, such as constipation or diarrhea; its mechanism of action is well described elsewhere . In contrast, for many years, dietary fat has been studied in non‐GI diseases, but only recently, the impact of FAs on GI function has become an attractive area of study to combat various GI‐related disorders . There are some clear signals that dietary FAs are relevant factors in the pathogenesis of GI disorders, but to our knowledge, most results were based on retrospective or prospective evaluation of dietary questionnaires, which raises the possibility of recall bias.…”

Section: Introductionmentioning

confidence: 99%

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Mosińska

Martín‐Ruíz

González

et al. 2019

Neurogastroenterology Motil

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Background Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity. Methods Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated. Results SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P < 0.01). SOY, COCO, and EP displayed decreased size of the cecum, lower number and size of fecal pellets, and higher infiltration of MCs to the colon (P < 0.001). Conclusions and Inferences Dietary FAs supplementation and lower intake of insoluble fiber can induce changes in the motility of the lower GI tract, in vivo and in vitro, but CV function and visceral sensitivity are not generally affected.

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“…Furthermore, recent findings suggest even a putative positive effect of dietary fat in IBS[42,43]. Polyunsaturated fatty acids and their metabolites can exhibit beneficial effects on intestinal inflammation[42].…”

Section: First-line Dietary Approach In Ibsmentioning

confidence: 99%

Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!

Cozma-Petruț

Loghin

Miere

et al. 2017

WJG

119

131

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A substantial proportion of patients with irritable bowel syndrome (IBS) associate their symptoms with the ingestion of specific foods. Therefore, in recent years, scientific research has increasingly focused on the role of diet in IBS and dietary management is now considered an important tool in IBS treatment. This article reviews the main dietary approaches in IBS emphasizing evidence from experimental and observational studies and summarizing the main diet and lifestyle recommendations provided by dietary guidelines and scientific literature. Despite the limited evidence for a beneficial role, general advice on healthy eating and lifestyle is recommended as the first-line approach in the dietary management of IBS. Standard recommendations include adhering to a regular meal pattern, reducing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as performing regular physical activity and ensuring a good hydration. Second-line dietary approach should be considered where IBS symptoms persist and recommendations include following a low FODMAP diet, to be delivered only by a healthcare professional with expertise in dietary management. The efficacy of this diet is supported by a growing body of evidence. In contrast, the role of lactose or gluten dietary restriction in the treatment of IBS remains subject to ongoing research with a lack of high-quality evidence. Likewise, further clinical trials are needed to conclude the efficacy of probiotics on IBS symptoms.

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Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer

Cited by 76 publications

References 129 publications

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!

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