Polyunsaturated fatty acids and T‐cell function: Implications for the neonate

Field, Catherine J.; Clandinin, Michael T.; Aerde, John E. Van

doi:10.1007/s11745-001-0813-6

Cited by 68 publications

(42 citation statements)

References 93 publications

(156 reference statements)

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“…105,106 Any beneficial effects of breastfeeding on offspring immune responses may be due to stimulation of helper T (Th) sub-type-1 development, which produce more Il2 and IFN-γ than Th2 cells, cells who instead are characterized by greater production of IL4, Il10 and Il13. 107 …”

Section: Gut Microbiome and Immune Effectsmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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Section: Gut Microbiome and Immune Effectsmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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“…DHA, 4 a major -3 polyunsaturated fatty acid, is particularly prevalent in neuronal tissues, and its content in maternal breast milk correlates with both neural development end points and immune status in the fetus (9,10). DHA is also essential for proper T cell development in neonates (11) and regulates T cell functions, with a polarizing preference toward the T H 2 phenotype as well as promotion of apoptosis in T H 1-polarized CD4 ϩ T cells (12,13). Consequently, T H 2 cells are potent suppressors of inflammatory and autoimmune disorders, particularly in the central nervous system (14).…”

mentioning

confidence: 99%

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

Ariel

Wang

et al. 2005

Journal of Biological Chemistry

217

193

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Docosahexaenoic acid, a major -3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated. In this study we found, using lipid mediator informatics employing liquid chromatography-tandem mass spectrometry, that (10,17S)-docosatriene/neuroprotectin D1, now termed protectin D1 (PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood mononuclear cells in a lipoxygenase-dependent manner. PD1 blocked T cell migration in vivo, inhibited tumor necrosis factor ␣ and interferon-␥ secretion, and promoted apoptosis mediated by raft clustering. These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution.

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“…Field и соавт. [30] изучалось влияние питания, обогащенного и не содержа-щего ДГК и АК, на жирнокислотный состав лимфоцитов периферической крови у недоношенных и доношенных новорожденных. Установлено, что добавление ДЦПНЖК в детские смеси влияло на степень зрелости лимфоцитов периферической крови и продукцию цитокинов.…”

Section: обзор литературыunclassified

Long-Chain Polyunsaturated Fatty Acids and Their Role in Children Nourishment

Боровик¹,

Грибакин²,

Скворцова³

et al. 2012

Vopr. sovr. pediatr.

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Несомненным достижением нутрициологии в пос-ледней четверти ХХ в. являются результаты детального изучения роли длинноцепочечных полиненасыщенных жирных кислот (ДЦПНЖК) в питании человека и в осо-бенности их значение в метаболизме и развитии мозга у детей первого года жизни [1,2]. Отправной точкой при проведении исследований в этом направлении послужили данные об их содержании в грудном молоке [3][4][5]. Было установлено, что грудное молоко содержит относительно низкие концентрации короткоцепочечных жирных кислот и в то же время -значительные количе-ства ДЦПНЖК, в частности арахидоновой (АК) и докоза-гексаеновой (ДГК) [6,7].Показано, что содержание АК в грудном молоке составляет 0,3-0,6%, и ее концентрация относительно стабильна в различных регионах мира, причем не имеет тесной связи с питанием матери. Напротив, содержа-ние ДГК варьирует в достаточно широком диапазоне (от 0,1 до 1,0%) и хорошо коррелирует с содержанием этой кислоты в рационе кормящей женщины [8,9].Важно отметить, что содержание ДЦПНЖК в грудном молоке матерей, родивших недоношенных детей, выше, чем в таковом у женщин после срочных родов [10]. Установлено положительное влияние дополнительного введения АК и ДГК в состав детских молочных смесей на когнитивное развитие и остроту зрения у недоношен-ных детей, а также, хотя и в меньшей степени, у детей, родившихся в срок [11].Известно, что для детей первого года жизни харак-терны быстрый рост и развитие. Поэтому их рацион дол-жен включать в оптимальных количествах и сбаланси-рованных соотношениях основные пищевые вещества,

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Polyunsaturated fatty acids and T‐cell function: Implications for the neonate

Cited by 68 publications

References 93 publications

Homage to the ‘H’ in developmental origins of health and disease

Homage to the ‘H’ in developmental origins of health and disease

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

Long-Chain Polyunsaturated Fatty Acids and Their Role in Children Nourishment

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