Polyunsaturated fatty acids affect intestinal anaphylactic response in BALB/c mice sensitized with β-lactoglobulin

Haddi, A.; Guendouz, M.; Tabet, S. Ainad; Mehedi, Nabila; Khéroua, O.; Saïdi, D.

doi:10.1016/j.reval.2018.03.009

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Research into the effects of fatty acids on the immune system has revealed the roles of eicosanoids derived from AA in promoting inflammation; but the knowledge on long chain n-3 PUFA suggests that it can inhibit the metabolism of AA to produce its inflammatory mediators [ 189 ]. Studies conducted in laboratory animals showed an increased incorporation of n-3 fatty acids, as EPA and DHA, into phospholipids compared with saturated or monounsaturated fatty acids [ 190 ]. Feeding diets containing EPA can results in partial replacement of AA in the membrane of cells that are involved in inflammation, such as monocytes, macrophages, and neutrophils.…”

Section: Feeding Systems Antioxidant Actions and Their Impact On Prod...mentioning

confidence: 99%

The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality—Invited Review

Ponnampalam

Kiani

Santhiravel

et al. 2022

Animals

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The biological effects of oxidative stress and associated free radicals on farm animal performance, productivity, and product quality may be managed via dietary interventions—specifically, the provision of feeds, supplements, and forages rich in antioxidants. To optimize this approach, it is important first to understand the development of free radicals and their contributions to oxidative stress in tissue systems of farm animals or the human body. The interactions between prooxidants and antioxidants will impact redox homeostasis and, therefore, the well-being of farm animals. The impact of free radical formation on the oxidation of lipids, proteins, DNA, and biologically important macromolecules will likewise impact animal performance, meat and milk quality, nutritional value, and longevity. Dietary antioxidants, endogenous antioxidants, and metal-binding proteins contribute to the ‘antioxidant defenses’ that control free radical formation within the biological systems. Different bioactive compounds of varying antioxidant potential and bio-accessibility may be sourced from tailored feeding systems. Informed and successful provision of dietary antioxidants can help alleviate oxidative stress. However, knowledge pertaining to farm animals, their unique biological systems, and the applications of novel feeds, specialized forages, bioactive compounds, etc., must be established. This review summarized current research to direct future studies towards more effective controls for free radical formation/oxidative stress in farm animals so that productivity and quality of meat and milk can be optimized.

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Section: Feeding Systems Antioxidant Actions and Their Impact On Prod...mentioning

confidence: 99%

The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality—Invited Review

Ponnampalam

Kiani

Santhiravel

et al. 2022

Animals

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“…The protective effects of n-3 PUFAs in the gut are repeatedly confirmed in the in vivo set up. In the mouse model of intestinal anaphylactic response to the cow's milk, low-dose n-3 PUFA (fish oil) supplementation decreases electrophysiological parameters such as short-current circuit and tissue conductance, followed by the improved morphological composition of the jejunal tissue [37]. In the IL-10-deficient mouse model of chronic colitis, supplementation with DHA significantly reduces the inflammatory score, prevents body weight loss, and decreases the production of pro-inflammatory cytokines (IL-17, TNF-α, and IFN-γ) [38].…”

Section: Epitheliummentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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“…Fish oil, containing both EPA and DHA, has also exhibited protective effects on gut histology in other models, including reducing mucosal damage and preventing tight junction protein redistribution in a rat haemorrhagic shock model [ 45 ], as well as increasing villous length and crypt depth/villous length ratio in a female Sprague–Dawley rat model of peritoneal dialysis [ 51 ]. Fish oil also significantly increased villous height and improved histological architecture scores in β-lactoglobulin-treated female BALB/c mice, as well as preventing changes to short current circuit and tissue conductance in jejunal tissue [ 50 ]. EPA-enriched fish oil, given over a 6 week period, also reduced macroscopic inflammation parameters in an acetic acid-induced colitis model [ 38 ].…”

Section: ω-3 Pufas and Intestinal Epithelial Morphologymentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review

Durkin

Childs

Calder

2021

Foods

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Epithelial cells (enterocytes) form part of the intestinal barrier, the largest human interface between the internal and external environments, and responsible for maintaining regulated intestinal absorption and immunological control. Under inflammatory conditions, the intestinal barrier and its component enterocytes become inflamed, leading to changes in barrier histology, permeability, and chemical mediator production. Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) can influence the inflammatory state of a range of cell types, including endothelial cells, monocytes, and macrophages. This review aims to assess the current literature detailing the effects of ω-3 PUFAs on epithelial cells. Marine-derived ω-3 PUFAs, eicosapentaenoic acid and docosahexaenoic acid, as well as plant-derived alpha-linolenic acid, are incorporated into intestinal epithelial cell membranes, prevent changes to epithelial permeability, inhibit the production of pro-inflammatory cytokines and eicosanoids and induce the production of anti-inflammatory eicosanoids and docosanoids. Altered inflammatory markers have been attributed to changes in activity and/or expression of proteins involved in inflammatory signalling including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator activated receptor (PPAR) α and γ, G-protein coupled receptor (GPR) 120 and cyclooxygenase (COX)-2. Effective doses for each ω-3 PUFA are difficult to determine due to inconsistencies in dose and time of exposure between different in vitro models and between in vivo and in vitro models. Further research is needed to determine the anti-inflammatory potential of less-studied ω-3 PUFAs, including docosapentaenoic acid and stearidonic acid.

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Polyunsaturated fatty acids affect intestinal anaphylactic response in BALB/c mice sensitized with β-lactoglobulin

Cited by 6 publications

References 30 publications

The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality—Invited Review

The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality—Invited Review

The Influence of Dietary Fatty Acids on Immune Responses

Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review

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