Polyunsaturated Fatty Acid Levels of Serum and Red Blood Cells in Apparently Healthy Japanese Subjects Living in an Urban Area

Yanagisawa, Naotake; Shimada, Kazunori; Miyazaki, Tatsuya; Kume, Atsumi; Kitamura, Yohei; Ichikawa, Ryoko; Ohmura, Hirotoshi; Kobayashi, Takashi; Hiki, Makoto; Fujita, Kosuke; Sumiyoshi, Katsuhiko; Hirose, Kuniaki; Matsumori, Rie; Takizawa, Hirotaka; Fujii, Kiyotaka; Mikami, Hiroshi; Inoue, Nao; Daida, Hiroyuki

doi:10.5551/jat.2618

Cited by 83 publications

(83 citation statements)

References 41 publications

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“…Serum EPA concentrations increase with age in apparently healthy Japanese 18 . In the present study, however, there was no significant correlation between log EPA and age in patients with type 2 diabetes.…”

Section: Discussioncontrasting

confidence: 90%

Dipeptidyl‐peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations

Senmaru

Fukui

Kobayashi

et al. 2012

J of Diabetes Invest

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Aims/Introduction: Eicosapentaenoic acid (EPA) stimulates glucagon‐like peptide‐1 (GLP‐1) secretion in mice. We investigated the relationship between serum EPA concentrations and the efficacy of dipeptidyl‐peptidase IV (DPP‐4) inhibitor in patients with type 2 diabetes.Materials and Methods: Serum EPA concentrations were measured in 62 consecutive patients with type 2 diabetes who were newly given DPP‐4 inhibitor as a monotherapy or as an add‐on therapy to oral hypoglycemic agents. The dosage of oral hypoglycemic agents was maintained during the observation period. After 24 weeks of treatment with DPP‐4 inhibitor, we evaluated the relationships between a decrease in hemoglobin A1c from baseline and serum EPA concentrations, as well as age, sex, body mass index (BMI), hemoglobin A1c at baseline and usage of antidiabetic concomitant drugs.Results: Hemoglobin A1c was significantly decreased from 8.1 ± 1.1% to 7.2 ± 1.0% by DPP‐4 inhibitor. A decrease in hemoglobin A1c correlated with BMI (r = −0.396, P = 0.0013), age (r = 0.275, P = 0.0032), hemoglobin A1c at baseline (r = 0.490, P < 0.0001) and log EPA (r = 0.285, P = 0.0246). Multiple regression analysis showed that BMI (β = −0.419, P = 0.0002), hemoglobin A1c at baseline (β = 0.579, P < 0.0001) and log EPA (β = 0.220, P = 0.0228) were independent determinants of decrease in hemoglobin A1c.Conclusions: DPP‐4 inhibitor is effective in patients with type 2 diabetes with high serum EPA concentrations. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2012.00220.x , 2012)

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Section: Discussioncontrasting

confidence: 90%

Dipeptidyl‐peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations

Senmaru

Fukui

Kobayashi

et al. 2012

J of Diabetes Invest

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“…In our study, the ratios of serum EPA/AA and DHA/AA in STEMI patients significantly varied in the male patients according to the age groups and were lower in younger men, as is the case for healthy people. 22) The distribution of the ratios of serum PUFAs was not affected by the occurrence of STEMI. The fact that the ratios of serum EPA/AA and DHA/AA did not significantly vary in the female patients according to the age groups can be attributed to the small number of women.…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of PUFAs are known to be differently distributed according to sex and age, reflecting dietary habits and age-related changes, and residential areas with different levels of fish consumption, [22][23][24][25][26] but their tendencies in STEMI patients remain unclear. In our study, the ratios of serum EPA/AA and DHA/AA in STEMI patients significantly varied in the male patients according to the age groups and were lower in younger men, as is the case for healthy people.…”

Section: Discussionmentioning

confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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SummaryA relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, and other laboratory data during hospitalization were evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than that in the 1VD group (55.5 ± 22.1 versus 66.2 ± 28.7, P = 0.002) and was slightly lower than that in the 2VD group (55.5 ± 22.1 versus 65.2 ± 28.9, P = 0.0167). Multivariate adjustment analysis revealed that age !70 years (odds ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low serum EPA level may be more strongly related than a low serum DHA level to the extent of VD in STEMI patients. Age !70 years and a low serum EPA level may be independent risk factors for 3VD/LMTD.(Int Heart J 2017; 58: 868-873) Key words: Eicosapentaenoic acid, Docosahexaenoic acid, Mulivessel disease, Acute coronary syndrome, Cardiovascular disease A n association between fish intake and risk of cardiovascular disease has been demonstrated in several epidemiological studies and clinical trials.

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“…It was noted that AA accelerates platelet aggregation and inflammatory reactions, and EPA works as an antagonistic regulator of AA. Recently, a significant positive correlation between EPA/AA ratios and insulin sensitivity as well as a negative correlation between those ratios and insulin resistance were observed in a subject with metabolic syndrome 18) . In fact, we expect that the EPA/AA ratio, which shows the balance of each PUFA concentration, may be used as a precise biomarker for arteriosclerotic disease; however, our results cannot provide definitive target levels since they were obtained through a comparison of control patients with a relatively low EPA concentration in the Japanese population.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Plasma Fatty Acid Composition and Coronary Artery Disease

Itakura¹,

Yokoyama

Matsuzaki

et al. 2011

JAT

202

146

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Aim:The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid (EPA). The aim of this study was to examine the relationships between various plasma fatty acid concentrations and the risk of coronary events in JELIS participants. Methods: In 15,534 participants, we calculated the hazard ratio for major coronary events (sudden cardiac death, fatal or nonfatal myocardial infarction, unstable angina pectoris, and angioplasty/ stenting or coronary artery bypass grafting) relative to the on-treatment average level of plasma fatty acids with the Cox proportional hazard model. Results: As a result of EPA intervention, the plasma EPA concentration increased, but the docosahexaenoic acid (DHA) concentration did not. The other fatty acids measured decreased slightly. The higher plasma level of EPA (hazard ratio 0.83, p 0.049, in all participants and hazard ratio 0.71, p 0.018, in the EPA intervention group), but not of DHA, was inversely associated with the risk of major coronary events. The associations between other fatty acids and the risk of major coronary events were not significant. In all JELIS participants, the risk of major coronary events was significantly decreased (20%) in the group with high (150 g/mL or more) on-treatment plasma EPA concentration compared with that in the low (less than 87 g/mL) group. Conclusion: The risk of coronary artery disease is influenced by variations in plasma fatty acid composition. Among n-3 polyunsaturated fatty acids, EPA and DHA exhibited differences in the correlation with the risk of major coronary events. J Atheroscler Thromb, 2011; 18:99-107.

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Polyunsaturated Fatty Acid Levels of Serum and Red Blood Cells in Apparently Healthy Japanese Subjects Living in an Urban Area

Abstract: Aim:We assessed levels of polyunsaturated fatty acid (PUFA) in serum and red blood cells (RBCs) among groups stratified by generation and its clinical significance in Japanese subjects living in an urban area.

Cited by 83 publications

References 41 publications

Dipeptidyl‐peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations

Dipeptidyl‐peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Relationships between Plasma Fatty Acid Composition and Coronary Artery Disease

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