Polythiophene as a near full pH photo-antimicrobial

Lang, Yunhe; Wang, Ying; Zhou, Ronghui; Zeng, Xiaofeng; Zhao, Hang; Wu, Peng

doi:10.1039/d2tb00727d

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…One method is to transform cellulose into carbon nanofiber aerogels by high-temperature carbonization. − However, carbon materials are prone to shrinkage and brittle after high-temperature treatment . Another method involves mixing cellulose with a conductive substance, such as MXene, silver nanowire (AgNWs), , reduced graphene oxide (rGO), and conductive polymers (such as polypyrrole, polyaniline, and polythiophene). − …”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanofibers/PEDOT:PSS Conductive Aerogel for Pressure Sensing Prepared by a Facile Freeze-Drying Method

Yan

Wang

et al. 2023

ACS Appl. Polym. Mater.

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The application of flexible wearable pressure sensors in the fields of pressure sensing, electronic skin, and human health monitoring has attracted a lot of attention. Herein, cellulose-nanofiber (CNF)-based aerogels with conducting polymer poly(3,4-ethylene dioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) and glutaraldehyde (GA) as cross-linking agent were designed and prepared by sol–gel cross-linking and freeze-drying. Without any special treatment, these aerogels presented good flexibility and piezoresistive properties. As the analysis of SEM, Raman spectrum, and XPS, the introduction of GA not only improves the mechanical properties of aerogel (the compressive strength at 80% strain has increased from 48 to 66 kPa) but also affects the doping state of PEDOT, which improves the sensitivity of aerogel (from 10.65 to 15.18 kPa–1). In addition, the sensor has been successfully applied to monitor human movements, including not only large movements (joint movements) but also small-scale muscle movements (cheek puffing and articulation recognition). It shows its potential as a widely used green pressure sensor.

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Section: Introductionmentioning

confidence: 99%

Cellulose Nanofibers/PEDOT:PSS Conductive Aerogel for Pressure Sensing Prepared by a Facile Freeze-Drying Method

Yan

Wang

et al. 2023

ACS Appl. Polym. Mater.

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“…18,19 Probably, due to rapid photobleaching, organic PSs cannot continuously produce reactive oxygen species (ROS) for degradation of algae under long-term irradiation. 20 Therefore, there is a pressing need for an economic and environmentally friendly photosensitizer that is capable of both highly efficient cyanobacterial inactivation and minimal secondary pollution.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For CLSM, the algal cells were transferred to a slide (PT10: FITC channel, Chlorophyll a: Cy5 channel) for imaging. For SEM, the cells were fixed with 2.5% glutaraldehyde for 2−3 h at room temperature, followed by sequential dehydration with increasing concentrations of ethanol (20,30,50,75,90, and 100%) for 15 min. The obtained solutions were dropped onto the conductive silicon and examined with SEM after drying.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Inorganic photosensitizers (PSs), such as metal oxides (e.g., TiO 2 and Ag 2 O), , metal salt (e.g., AgPO 4 ), and g-C 3 N 4 , , are famous for their high efficiency in algae degradation but are typically disposed in a relatively high dosage and relatively difficult to be recycled (Table S1). On the other hand, organic photosensitizers, such as chlorin e6, riboflavin, and erythrosine B, are well known for their low cost and low toxicity but are less used for photoinactivation of cyanobacteria. , Probably, due to rapid photobleaching, organic PSs cannot continuously produce reactive oxygen species (ROS) for degradation of algae under long-term irradiation . Therefore, there is a pressing need for an economic and environmentally friendly photosensitizer that is capable of both highly efficient cyanobacterial inactivation and minimal secondary pollution.…”

Section: Introductionmentioning

confidence: 99%

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Self-Immolative Polythiophene for Sunlight Inactivation of Harmful Cyanobacteria

Lang,

Wang,

Zhou

et al. 2023

Environ. Sci. Technol.

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Harmful cyanobacterial blooms and the released microcystins (MCs) caused serious environmental and public health concerns to drinking water safety. Photo-oxidation is an appealing treatment option and alternative to conventional flocculation and microbial antagonists, but the performances of current photosensitizers (either inorganic or organic) are unsatisfactory. Here, a polythiophene photosensitizer (PT10) with both high yield of reactive oxygen species (ROS) production (mainly 1O2, ΦΔ = 0.51, > 8 h continuous generation) and moderate photostability was used as a powerful algaecide to inhibit Microcystis aeruginosa. Due to the positive charge of PT10, the algal cells were quickly flocculated, followed by efficient inactivation in 4 h under white light irradiation (96.7%, 10 mW/cm2). Meanwhile, PT10 was self-immolated in about 6 h. Upon biosafety evaluation with adult zebrafish, the low toxicity of PT10 and the degradation products of PT10 and algae (early logarithmic growth stage) were confirmed. In addition, microcystin-LR (MC-LR), a toxic microcystin that will be released during the destruction of the algal cells, was also degraded. Therefore, PT10-based photoinactivation of M. aeruginosa featured both high performance and low secondary pollution. In real-world aquatic systems, PT10 was confirmed to be capable of sunlight-assisted inactivation of M. aeruginosa and prevent algal blooms, thus making it appealing for environmental remediation.

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Cisplatin‐coordinated copolythiophene for synergistic chemotherapy and sonodynamic therapy of tumor

Tang,

Pang,

Zhu

et al. 2024

Smart Molecules

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Sonodynamic therapy (SDT) is a novel cancer treatment type showing the advantages of high tissue penetration ability, non‐invasion, low systemic toxicity, and high selectivity. However, SDT depends on ultrasound (US) irradiation; once US is turned off, the sonosensitizer will stop producing reactive oxygen species (ROS). Moreover, most sonosensitizers generate oxygen‐dependent ROS, that is, singlet oxygen (1O2), significantly limiting the therapeutic effect of SDT in treating deep and hypoxic tumor. Therefore, combining SDT with other treatment modalities is essential. Here, we designed and synthesized a series of cisplatin‐coordinated copolythiophenes (CPT‐Pts), simultaneously generating 1O2, superoxide anion, and hydroxyl radicals for synergistic chemotherapy and SDT of tumor. The sonodynamic toxicity and cytotoxicity of CPT‐Pts were accurately regulated by tuning the monomer ratio of the polythiophene. This copolymerization strategy avoids the side effects originating from the high‐dose chemotherapy drug while making up for limiting SDT relying on ultrasonic activation, effectively inhibiting cancer cells and tumors.

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Polythiophene as a near full pH photo-antimicrobial

Abstract: Microbial infections are currently one of the world’s major public health cares, the evolution of which has resulted in the development of multiple tolerances (not just the drug or antibiotic...

Cited by 4 publications

References 48 publications

Cellulose Nanofibers/PEDOT:PSS Conductive Aerogel for Pressure Sensing Prepared by a Facile Freeze-Drying Method

Cellulose Nanofibers/PEDOT:PSS Conductive Aerogel for Pressure Sensing Prepared by a Facile Freeze-Drying Method

Self-Immolative Polythiophene for Sunlight Inactivation of Harmful Cyanobacteria

Cisplatin‐coordinated copolythiophene for synergistic chemotherapy and sonodynamic therapy of tumor

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