Polysulfonylated cyclodextrins. Part 14. Structural validation of tris-and pentakis(6-O-mesitylsulfony)cyclomaltooctaose isomers by¹H-NMR spectrometry

Abstract

Regioisomers of tri‐ and penta‐6‐O‐mesitylenesulfonates of cyclomaltoctaose (γ‐cyclodextrin) were discriminated and assigned by high‐resolution 1H NMR techniques.

Chemical Modification of Cyclodextrin and Amylose by Click Reaction and Its Application to the Synthesis of Poly-alkylamine-Modified Antibacterial Sugars

“…To this end, poly-sulfonylated CD derivatives have been studied. [2][3][4] The second important thing to be examined is a method for introducing functional moieties onto a CD molecule. Recently we found that CD derivatives 1 possessing polyamino groups (more than six on the molecule) strongly disrupted bacterial membranes; the addition of benzyl moieties to the amino groups (CD derivative 2) enhanced the membrane permeabilization and inhibited bacteria proliferation 5) (Chart 1).…”