Polysulfone--poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Park, Jane Y.; Acar, Metin H.; Akthakul, Ariya; Kuhlman, William; Mayes, Anne M.

doi:10.1016/j.biomaterials.2005.07.010

Cited by 325 publications

(167 citation statements)

References 41 publications

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“…That is the reason why acidic proteins adhere easier to the dialyzer membranes. It was reported that adding PVP (polyvinyl pyrrolidone) or PEG (polyethylene glycol) hydrophilic groups can improve the hydrophobic characteristics of polysulfone membrane [30,31] . The mechanism of such improvement is in fact a certain degree of 'shielding' of the positively charged region.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

Yang

Zhu

2009

Blood Purif

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In order to study the mechanism of protein adhesion on the Fresenius F6 polysulfone membrane dialyzer, two-dimensional gel electrophoresis, LC-ESI-MS/MS and bioinformatics methods were used to analyze the protein which adhered to the dialyzer membrane. Six of the adhered proteins account for more than 50% of the total 179 proteins, i.e. ficolin precursor, complement C3 precursor, 3 variants of MASP1 and albumin. The results also showed that easily adhered proteins have a greater percentage of acidic amino acids (p < 0.01). The isoelectric point of the 20 proteins with the most deposits is 6.2 ± 1.08, which is obviously lower than of those with the least deposits (7.56 ± 1.36, p < 0.01). The dipole moment of a polysulfone membrane molecule has a tendency to absorb molecules with a negative charge. These results are of significance in understanding and improving membrane protein interactions.

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Section: Discussionmentioning

confidence: 99%

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

Yang

Zhu

2009

Blood Purif

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“…In many investigations, short-term (2-6 h) static protein or bacterial cell adhesion tests were performed [11,[42][43][44]. In some other cases short-term (2-24 h) cross-flow or dead end filtration tests were used to evaluate the impact of the coating on biofilm accumulation [9,16,[45][46][47].…”

Section: Need For Long-term Biofouling Studiesmentioning

confidence: 99%

Coating of reverse osmosis membranes with amphiphilic copolymers for biofouling control

Bucs¹,

Linares²,

Siddiqui³

et al. 2017

Desalination and Water Treatment

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a b s t r a c tSurface coating of membranes may be a promising option to control biofilm development and biofouling impact on membrane performance of spiral-wound reverse osmosis (RO) systems. The objective of this study was to investigate the impact of an amphiphilic copolymer coating on biofilm formation and biofouling control. The coating was composed of both hydrophilic and hydrophobic monomers hydroxyethyl methacrylate (HEMA) and perfluorodecyl acrylate (PFA), respectively. Commercial RO membranes were coated with HEMA-PFA copolymer film. Long and short term biofouling studies with coated and uncoated membranes and feed spacer were performed using membrane fouling simulators (MFSs) operated in parallel, fed with water containing nutrients. For the long-term studies pressure drop development in time was monitored and after eight days the MFSs were opened and the accumulated biofilm on the membrane and spacer sheets was quantified and characterized. The presence of the membrane coating was determined using X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). Results showed that the amphiphilic coating (i) delayed biofouling (a lower pressure drop increase by a factor of 3 and a lower accumulated active biomass amount by a factor of 6), (ii) influenced the biofilm composition (23% lower polysaccharides and 132% higher protein content) and (iii) was still completely present on the membrane at the end of the biofouling study, showing that the coating was strongly attached to the membrane surface. Using coated membranes and feed spacers in combination with advanced cleaning strategies may be a suitable way to control biofouling.

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“…Therefore, there are growing interests in developing hydrophilic polysulfone membrane surfaces. Several methods have been created to obtain hydrophilic polysulfone membrane surfaces, such as hydrophilic polymer coatings deposited onto the polysulfone membrane surface (Lee et al, 2000;Higuchi et al, 2003); chemical reaction of hydrophilic components onto the bulk polysulfone backbone (Summers et al, 2003;Lu et al, 2005;Park et al, 2006); hydrophilic layers graft-polymerized onto polysulfone membranes using radical reactions generated with low temperature plasma (Steen et al, 2001), gamma radiation (Mok et al, 1994) or UV irradiation (Kaeselev et al, 2001;Taniguchi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Anti-fouling ultrafiltration membrane prepared from polysulfone-graft-methyl acrylate copolymers by UV-induced grafting method

Hao

et al. 2008

Journal of Environmental Sciences

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Membrane fouling is one of the most important challenges faced in membrane ultrafiltration operations. The copolymers of polysulfone-graft-methyl acrylate were synthesized by homogeneous photo-initiated graft copolymerization. The variables affecting the degree of grafting, such as the time of UV (Ultraviolet-visible) irradiation and the concentrations of the methyl acrylate and photoinitiator, were investigated. The graft copolymer membranes were prepared by the phase inversion method. The chemical and morphological changes were characterized by attenuated total reflection-Fourier transform infrared spectroscopy (ATR/FT-IR), scanning electron microscopy, and water contact angles measurements. Results revealed that methyl acrylate groups were present on the membranes and the graft degree of methyl acrylate had remarkable effect on the performance of membranes. Pure water contact angle on the membrane surface decreases with the increase of methyl acrylate graft degree, which indicated that the hydrophilicity of graft copolymer membranes was improved. The permeation fluxes of pure water and bovine serum albumin solution were measured to evaluate the antifouling property of graft copolymer membranes, the results of which have shown an enhancement of antifouling property for graft copolymer membranes.

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Polysulfone--poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Cited by 325 publications

References 41 publications

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

Coating of reverse osmosis membranes with amphiphilic copolymers for biofouling control

Anti-fouling ultrafiltration membrane prepared from polysulfone-graft-methyl acrylate copolymers by UV-induced grafting method

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