“…MESNA can form complexes with metal ions such as Pd(II), Pt(II), Ag(I), Cd(II) and Zn(II) with multiple anionic sulfonate sites. The platinum complex exhibited less cytotoxicity but impressive antiviral activity against HIV‐1 and HIV‐2, herpes simplex virus type 1 (HSV‐1) and HSV‐2, human cytomegalo virus, vesicular stomatitis virus (VSV), influenza A virus, respiratory syncytial virus (RSV), Sindbis virus, Junin virus and Tacaribe virus . The palladium complex of MESNA is found active against both HIV‐1 and HIV‐2 and zinc complex is moderately active against VSV, RSV, Junin virus, and Tacaribe virus.…”