Polystyryl-supported TBD as an efficient and reusable catalyst under solvent-free conditions

Abstract

Polystyryl supported-TBD (PSTBD) is an efficient and reusable heterogeneous basic catalyst under solvent-free conditions for a variety of organic transformations such as 1,2-epoxide ring-opening, aldol-type condensation and Michael addition.

Amberlite IRA900F as a Solid Fluoride Source for a Variety of Organic Transformations under Solvent‐Free Conditions

“…In the last few years, we have been contributing in this field and we have demonstrated that solvent‐free conditions (SolFC) have beneficial effects on some organic transformations,7 such as Michael additions,7a,7j oxirane ring‐opening reactions,7e,7f Diels–Alder reactions,7g–7i and [3+2]7c,7d and 1,3‐dipolar7b cycloadditions allowing the chemically and environmentally efficient preparation of target molecules such as 1 H ‐1,2,3‐triazoles, 1 H ‐tetrazoles, biphenyl‐2‐ylcarbonitriles, and benzo[ e ]1,4‐oxathiepin‐5‐ones among others.…”

Improving Solid‐Supported Catalyst Productivity by Using Simplified Packed‐Bed Microreactors

“…As an example, we reacted 1,5,7‐triazabicyclo[4.4.0]undec‐3‐ene (TBD, 2 ) with the epoxide (Scheme 1). Solid‐supported TBD has been shown to catalyze a number of reactions1a, 13 but had not yet been used in a pressure‐driven flow system 12. 14 TBD on AO (AO–TBD, 3 , Scheme 1) is a highly active, Knoevenagel catalyst in batch systems but works significantly better in flow systems.…”

Definition of green synthetic tools based on safer reaction media, heterogeneous catalysis, and flow technology

“…We have used flow technology as an effective mixing technology in the combination of heterogeneous catalysts (organic and organometallic) and green reaction media such as azeotropes, water and also solventfree conditions proving that with this approach the chemical efficiency as well as the greenness of a synthetic methodology can be effectively maximized and some examples will be described below [66,[69][70][71][72][73][74][75][76][77][78].…”