Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish

Pei, Xin; Heng, Xing; Chu, Weihua

doi:10.1016/j.micpath.2021.105387

Cited by 45 publications

(7 citation statements)

References 46 publications

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“…Various nano-particles, although found to generate ROS in fish ( Paital et al, 2019 ), nano-technology is also used to be helpful for the health management in fish. Some of the nano-particles also seem useful in managing fish diseases ( Sahoo and Chatli, 2015 ; Stara et al, 2019 ; Yin et al, 2019 ; Liu et al, 2020 ; Kim et al, 2021 ; Pei et al, 2022 ; Xiao et al, 2023 ). Therefore, this review focused on how pesticides and microplastics induce the accumulation of ROS and oxidative and other stress in fish and their health management by use of nano-technology.…”

Section: Introductionmentioning

confidence: 99%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanoparticles generates ROS and induces oxidative stress, inflammation, immunotoxicity, genotoxicity, and DNA damage and alters gut microbiota, thus reducing the growth and quality of fish. Changes in fish behavioral patterns, swimming, and feeding habits were also observed under exposures to the above contaminants. These contaminants also affect the Nrf-2, JNK, ERK, NF-κB, and MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes in fish. Effects of pesticides, microplastics, and nanoparticles found to modulate many antioxidant enzymes, including superoxide dismutase, catalase, and glutathione system. So, to protect fish health from stress, the contribution of nano-technology or nano-formulations was researched. A decrease in fish nutritional quality and population significantly impacts on the human diet, influencing traditions and economics worldwide. On the other hand, traces of microplastics and pesticides in the habitat water can enter humans by consuming contaminated fish which may result in serious health hazards. This review summarizes the oxidative stress caused due to microplastics, pesticides and nano-particle contamination or exposure in fish habitat water and their impact on human health. As a rescue mechanism, the use of nano-technology in the management of fish health and disease was discussed.

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Section: Introductionmentioning

confidence: 99%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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“…As reported in zebrafish 221,227 and mice, 228 microplastics and nanoplastics cause microbiota dysbiosis in the gut (Figure 3), beginning with the mechanical disruption that provokes underfed animals and inflammation of the GIT 229 . When microplastics break into nanoplastics, they can cross biological barriers and migrate to other organs.…”

Section: Factors Leading To Diseasementioning

confidence: 71%

“…216 In the crab Uca rapax, the consumed microplastics are retained in the gills, stomach and hepatopancreas, potentially damaging the crab's health and affecting the body functions, including respiration, segregation of digestive enzymes, absorption of nutrients and storage of energy reserves, perturbing the biological performance of the animal. [223][224][225][226] As reported in zebrafish 221,227 and mice, 228 microplastics and nanoplastics cause microbiota dysbiosis in the gut (Figure 3), beginning with the mechanical disruption that provokes underfed animals and inflammation of the GIT. 229 When microplastics break into nanoplastics, they can cross biological barriers and migrate to other organs.…”

Section: Environmental Pollutionmentioning

confidence: 73%

Fish disease and intestinal microbiota: A close and indivisible relationship

Félix

Garibay-Valdez

Vargas‐Albores

et al. 2022

Reviews in Aquaculture

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The gut microbiota is currently one of the most studied 'organs' in animals, and fish are no exception. A complex diversity of microbes, including bacteria, archaea, yeast and fungus, constitute the gut microbiota, creating a complex interaction with their host and accomplishing multiple beneficial functions, such as food digestion, nutrient absorption, immune system, endocrine and stress response. The microbiotapathogen interaction protects the host by mounting colonization resistance, competing for nutrients and space. Changes in the balance of the microbiota community could affect their structure and homeostasis, inducing dysbiosis. In addition, invading pathogens can induce dysbiosis by evading the host's defence barriers, acquiring nutrients from the fish host, using metabolites produced by the microbiota and producing toxins. In this regard, understanding the interactions within the fish gut microbiota is essential to prevent pathogen establishment in the host. Hence, this review describes the close and indivisible relationships and interactions between gut microbiota and pathogens that could lead to dysbiosis and disease.

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“…Microplastic particles are easily consumed by aquatic animals and can enter the food chain (Wang et al 2020). They can induce oxidative stress, cytotoxicity (Lu et al 2016), DNA damage (Imhof et al 2017), reproductive toxicity (Liu et al 2022), inflammation (Von Moos et al 2012, disruption of immune responses (Pei et al 2022;Teng et al 2022), neurotoxicity (Lei et al 2018), and disruptions in the digestive, immunological, and respiratory systems in animals. Microplastics can also have serious health consequences for humans (Sangkham et al 2022).…”

Section: Microplasticsmentioning

confidence: 99%

Plastic recycling in South Korea: problems, challenges, and policy recommendations in the endemic era

Song,

Park

2024

J Ecol Environ

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Background: Despite many environmental problems, plastic waste emissions have been a significant surge during last few decades in the Republic of Korea. Furthermore, the emergence of the coronavirus disease 2019 (COVID-19) pandemic has lead to an increased use and disposal of plastic waste worldwide. This paper tried to present summarized data related to the production and disposal of plastics especially before and after the COVID-19 pandemic with environmental impacts of plastics. Also, review of plastic waste reduction policies and feasible policies to promote an act for a safe, sustainable environment are presented. Results: Plastics cause many environmental problems due to their non-degrading properties and have a huge direct and indirect impact on Ecosystems and Public Health. Microplastics need a lot of attention because their environmental effects are not yet fully identified. Despite plastic's significant impact on climate change, the impact is not yet widely known to the public. Since the COVID-19 pandemic, the use of plastic has surged and recycling has decreased due to the increase in delivery food and online shopping. Korea is introducing very active plastic and waste management policies, but it is necessary to implement more active policies by referring to the cases of other countries. Conclusions: In this article, we have scrutinized the evolution of plastic waste generation in the aftermath of the COVID-19 pandemic and delved into policy frameworks adopted by other nations, which South Korea can draw valuable lessons from. The formidable challenges posed by plastic waste, the remarkable shifts witnessed during the COVID-19 era, and the multifaceted response strategies elucidated in this paper all play a pivotal role in steering South Korea toward a sustainable future.

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Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish

Cited by 45 publications

References 46 publications

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Fish disease and intestinal microbiota: A close and indivisible relationship

Plastic recycling in South Korea: problems, challenges, and policy recommendations in the endemic era

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