Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish

Jin, Yuanxiang; Xia, Jizhou; Pan, Zihong; Yang, Jiajing; Wang, Qianqian; Fu, Zhengwei

doi:10.1016/j.envpol.2017.12.088

Cited by 607 publications

(252 citation statements)

References 69 publications

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“…Toxicological studies are rapidly increasing in environmental pollutants due to properties that are very harmful to humans and wildlife . The widespread use of IMZ has led to growing concerns about residual contaminants, which may exceed levels that are considered environmentally or biologically safe .…”

Section: Discussionmentioning

confidence: 99%

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

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Imazalil (IMZ), which is a widely used fungicide, can accumulate in the body and threaten an animal's health. However, this fungicide has adverse effects on aquatic organisms and ultimately affects human health when it leaches into the environment. Our research tried to determine that if IMZ might cause liver damage and its potential to cause-related diseases. In this study, male adult C57BL/6 mice were exposed to 0.1, 0.5, or 2.5 mg/kg body weight IMZ in drinking water for 15 weeks. Then, we evaluated the liver damage at the physiological, biochemical, and transcriptome levels in mice after chronic IMZ exposure. We observed serious ballooning degeneration of hepatocytes in the IMZ-treated groups. And IMZ induced oxidative stress and caused the disorders of bile acid metabolism in mice. In addition, the transcriptome data showed that IMZ has substantial influence on several pathways, including metabolic pathways for drug metabolism, RNA transport, and bile secretion. We further confirmed that the mRNA expression of the key genes involved in oxidative stress and bile acid metabolism were changed of mice exposed to IMZ. Our data suggested that chronic IMZ exposure could induce hepatotoxicity in mice at the physiological, biochemical, and transcriptome levels.

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Section: Discussionmentioning

confidence: 99%

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

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“…Contrarily, an experiment where brine shrimp larvae were exposed to 10 μm polystyrene particles found no effect on development, growth, or survival but reported that epithelial tissues of the intestinal tract were changed, possibly affecting digestive efficiency (Y. Wang, Zhang, et al, ). Similarly, Pedà et al () observed damage to the intestine of European sea bass following polyvinyl chloride pellet (3 mm) exposure and Jin et al () found that the intestinal epithelial tissues and mucous of mice were altered following ingestion of 5 μm polystyrene particles during a 6‐week exposure. These observations suggest that a major consequence of ingestion of microplastics may be filling or physical alteration of the digestive tract, compromising ingestion or assimilation of nutritious food.…”

Section: Microplastic Uptake and Consequences In Biotamentioning

confidence: 91%

“…As previously discussed, microplastic surfaces may develop novel biofilm microbiomes, potentially leading to specific microbial‐mediated consequences (Zettler et al, ). Jin et al () found that in addition to digestive tissue alterations, the gut microbiome of mice was substantially altered following polystyrene microplastic ingestion, modifying metabolic pathways including amino acid and bile metabolism. These authors suggested that such alterations could trigger metabolic disorders.…”

Section: Microplastic Uptake and Consequences In Biotamentioning

confidence: 99%

A Global Perspective on Microplastics

Hale¹,

Seeley²,

Guardia³

et al. 2020

JGR Oceans

658

270

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Society has become increasingly reliant on plastics since commercial production began in about 1950. Their versatility, stability, light weight, and low production costs have fueled global demand. Most plastics are initially used and discarded on land. Nonetheless, the amount of microplastics in some oceanic compartments is predicted to double by 2030. To solve this global problem, we must understand plastic composition, physical forms, uses, transport, and fragmentation into microplastics (and nanoplastics). Plastic debris/microplastics arise from land disposal, wastewater treatment, tire wear, paint failure, textile washing, and at-sea losses. Riverine and atmospheric transport, storm water, and disasters facilitate releases. In surface waters plastics/microplastics weather, biofoul, aggregate, and sink, are ingested by organisms and redistributed by currents. Ocean sediments are likely the ultimate destination. Plastics release additives, concentrate environmental contaminants, and serve as substrates for biofilms, including exotic and pathogenic species. Microplastic abundance increases as fragment size decreases, as does the proportion of organisms capable of ingesting them. Particles <20 μm may penetrate cell membranes, exacerbating risks. Exposure can compromise feeding, metabolic processes, reproduction, and behavior. But more investigation is required to draw definitive conclusions. Human ingestion of contaminated seafood and water is a concern. Microplastics indoors present yet uncharacterized risks, magnified by the time we spend inside (>90%) and the abundance of polymeric products therein. Scientific challenges include improving microplastic sampling and characterization approaches, understanding long-term behavior, additive bioavailability, and organismal and ecosystem health risks. Solutions include improving globally based pollution prevention, developing degradable polymers and additives, and reducing consumption/expanding plastic reuse.

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“…As a widely used fungicide, PM has been considered to have generally low toxicity, and the teratogenicity and neurotoxicity for mammals remain unclear . However, in some previous studies, PM was found to have a negative effect on different endpoints in different experimental animals especially regarding gut microbiota dysbiosis and hepatic lipid metabolism . Although no study reported that PM has the potential to induce to induce neurotoxicity in animals, similar studies addressing oral exposure to pesticides have shown that glyphosate in pregnant rats produced alterations in the activity of several brain enzymes in both mothers and offspring, decreased glutamate uptake, increased glutamate excitotoxicity in the hippocampi of exposed offspring and decreased locomotor activity and anxiety levels in adult rats perinatally.…”

Section: Discussionmentioning

confidence: 99%

“…The gene transcription was normalized to the level of GAPDH transcript in each sample. The following PCR protocol was used as denaturation for 1 minute at 95°C, followed by 40 cycles of 15 seconds at 95°C and 1 minute at 60°C according to previous studies …”

Section: Methodsmentioning

confidence: 99%

Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

Zhang

Jin

Wang

et al. 2018

Environmental Toxicology

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Propamocarb (PM) is a type of fungicide, which is widely used in the greenhouse-based production of vegetables and fruits globally. It has been considered to have generally low toxicity. However, the teratogenicity or neurotoxicity for mammals remains unclear. In this study, we aimed to explore its effect on the secretion of neurotransmitters and behavioral impairments.Male adult mice were exposed to 10 and 40 mg/L PM for 2 weeks (acute exposure) or 3 and 10 mg/L PM for 10 weeks (chronic exposure). It was observed that acute or chronic exposure to PM changed the levels of serotonin (5-HT) and dopamine in the serum and colon and the transcription of TPH2 and DRD2 in the colons of mice. In addition, the locomotor test, the open field test, and the Morris water maze analysis also showed that acute exposure to PM caused behavioral impairments to some extent. The results obtained in the present study indicated that PM has the potential to induce neurotoxicity in animals. K E Y W O R D Sbehavioral impairments, mice, neurotoxicity, neurotransmitters, propamocarb

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Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish

Cited by 607 publications

References 69 publications

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

A Global Perspective on Microplastics

Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

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