Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)

Usman, Sunusi; Razis, Ahmad Faizal Abdull; Shaari, Khozirah; Azmai, Mohammad Noor Amal; Saad, Mohd Zamri; Isa, Nurulfiza Mat; Nazarudin, Muhammad Farhan

doi:10.1016/j.toxrep.2022.05.001

Cited by 13 publications

(4 citation statements)

References 76 publications

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“…Potential toxicity of polystyrene microplastic particles have been studied mostly in animal models and marine life and it has been established that polystyrene microparticles induces a significant reduction in the richness and diversity of the gut bacterial microbiota. 4 Bezoars are seen very infrequently with an incidence of less than 1% in the general population and are rare causes of gastrointestinal obstruction. 5 Bezoars are an unusual complication of pica, but when they occur, they can be devastating, resulting in a 30% mortality rate if untreated.…”

Section: Discussionmentioning

confidence: 99%

Eating styrofoam balls presented as intestinal obstruction- PICA associated with bezoar: a rare case report and review of literature

Haji

Sivakumar²,

Piramanayagam³

et al. 2022

Int Surg J

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Gastrointestinal obstruction secondary to foreign body bezoars (industrial materials, plastic, tissue paper, sponge) have been reported but foreign body bezoar with styrofoam has never been reported in literature. PICA associated bezoars are an unusual complication and reports say that a wide variety of substances are consumed, ranging from socks, newspapers, and sofa pillows to dirt and hair and in this case, it was ingestion of styrofoam balls. Styrofoam being foam plastic does not breakdown or get absorbed in body when ingested, but its persistent ingestion creates bezoar which can fill the whole gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Eating styrofoam balls presented as intestinal obstruction- PICA associated with bezoar: a rare case report and review of literature

Haji

Sivakumar²,

Piramanayagam³

et al. 2022

Int Surg J

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“…Similar effects were also reported in the gut of the Javanese medaka O. javanicus exposed to 5 µm beads of PS MP suspensions at concentrations of 100 µg/L, 500 µg/L, and 1000 µg/L for a period of 21 days. In fact, the intestinal metabolic profile revealed an upregulation of nine metabolites related to energy metabolism, via the TCA cycle, creatine pathway, and urea cycle, therefore highlighting the potential health risks of MP toxicity for animals and, possibly, humans [119].…”

Section: Effects Of Ps Mnps On the Metabolome Of Fishesmentioning

confidence: 98%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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In recent years, micro- and nanoplastics (MNPs) have represented an emerging threat for the aquatic environment due to their persistence and widespread distribution. Indeed, their small size and increased surface area lead to a high biological reactivity, which can be crucial for the health status of biota. To date, several studies have investigated lethal and sublethal endpoints of MNPs, while one of the main challenges is to understand their mechanisms of toxicity in a comprehensive manner. With this aim, the field of aquatic ecotoxicology can now benefit from the -omics approaches. This review focuses on the recent advances related to the use of transcriptomics, proteomics, and metabolomics to deeply investigate the molecular and biochemical responses of aquatic organisms, both fishes and aquatic invertebrates, to pristine polystyrene (PS) MNPs. The literature reviewed revealed that transcriptomics and metabolomics are the most frequently used -omic approaches. Overall, the studies taken into consideration shed light on the events triggered by PS MNPs at molecular and cellular levels, identifying as mechanisms of toxicity the pathways involved in oxidative stress, energy metabolism, immune response, and the nervous system. Future studies should therefore focus on the use and integration of multi-omics approaches for a more comprehensive understanding of the mechanisms involved in MNPs toxicity.

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“…Several species develop nanoplastic-induced gut dysbiosis with health impacts [21]. This occurs in zebrafish [122][123][124], crayfish [125], and mice [126][127][128], and exposure to polyethylene microplastics also affects the immature human and non-human gut microbiome [129,130]. The gut microbiome influences neurodevelopment and when impaired can cause neurodevelopmental disorders [131,132].…”

Section: The Gut-brain Axis and Mnplsmentioning

confidence: 99%

Nanoplastics and Neurodegeneration in ALS

Eisen,

Pioro,

Goutman

et al. 2024

Brain Sciences

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Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via digestion, inhalation, and skin contact. Particles have been documented in all human tissues including breast milk. MNPLs, especially weathered particles, can breach the blood–brain barrier, inducing neurotoxicity. This has been documented in non-human species, and in human-induced pluripotent stem cell lines. Within the brain, MNPLs initiate an inflammatory response with pro-inflammatory cytokine production, oxidative stress with generation of reactive oxygen species, and mitochondrial dysfunction. Glutamate and GABA neurotransmitter dysfunction also ensues with alteration of excitatory/inhibitory balance in favor of reduced inhibition and resultant neuro-excitation. Inflammation and cortical hyperexcitability are key abnormalities involved in the pathogenic cascade of amyotrophic lateral sclerosis (ALS) and are intricately related to the mislocalization and aggregation of TDP-43, a hallmark of ALS. Water and many foods contain MNPLs and in humans, ingestion is the main form of exposure. Digestion of plastics within the gut can alter their properties, rendering them more toxic, and they cause gut microbiome dysbiosis and a dysfunctional gut–brain axis. This is recognized as a trigger and/or aggravating factor for ALS. ALS is associated with a long (years or decades) preclinical period and neonates and infants are exposed to MNPLs through breast milk, milk substitutes, and toys. This endangers a time of intense neurogenesis and establishment of neuronal circuitry, setting the stage for development of neurodegeneration in later life. MNPL neurotoxicity should be considered as a yet unrecognized risk factor for ALS and related diseases.

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Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)

Cited by 13 publications

References 76 publications

Eating styrofoam balls presented as intestinal obstruction- PICA associated with bezoar: a rare case report and review of literature

Eating styrofoam balls presented as intestinal obstruction- PICA associated with bezoar: a rare case report and review of literature

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Nanoplastics and Neurodegeneration in ALS

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