Polystyrene microplastic‐induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat
Qingqing Zhang,
Yuanyuan Lang,
Xiaomin Tang
et al.
Abstract:BackgroundPrevious studies on the effects of microplastics (MPs) on bone in early development are limited. This study aimed to investigate the adverse effects of MPs on bone in young rats and the potential mechanism.MethodsThree‐week‐old female rats were orally administered MPs for 28 days, and endoplasmic reticulum (ER) stress inhibitor salubrinal (SAL) and ER stress agonist tunicamycin (TM) were added to evaluate the effect of ER stress on toxicity of MPs. The indicators of growth and plasma markers of bone … Show more
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