Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery

Basharzad, Samaneh Fateh; Hamidi, Mehrdad; Maleki, Aziz; Karami, Zahra; Mohamadpour, Hamed; Zanjani, Mohammad Reza Saghatchi

doi:10.1016/j.brainres.2022.147786

Cited by 22 publications

(13 citation statements)

References 93 publications

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“…Analysis with HPLC idenitfied excellent-fitting linear responses ( R 2 > 0.99) for the buffer solutions, plasma, and brain homogenate over the concentration range of 50–4000 ng/mL. , The peak of MTX appeared at 5.2 min in the chromatogram. The LOD and LOQ values in buffer solutions were 22 and 73.1 ng/mL, respectively.…”

Section: Results and Discussionmentioning

confidence: 88%

“…Among these entities, MSNs have received great interest as drug carriers because of their biocompatibility, capability for facile surface modification via their silanol groups, as well as their amenability to control particle size and pore size. , The authors’ prior research in 2021 showed that polysorbate-coated MSNs could bypass the BBB and deliver rivastigmine, an anti-Alzheimer drug, into the brain. Nuropharmacokinetic studies confirmed that the brain uptake clearance of the rivastigmine-loaded MSNs was significantly higher than the free drug . This study highlighted the importance of surface functionalization of MSNs to enable them to function as effective drug carriers for delivery to the brain. , In the same year, angiopep-2 modified lipid-coated MSNs were introduced for glioma treatment.…”

Section: Introductionmentioning

confidence: 71%

“…Mesoporous silica-based nanosystems have been shown to be excellent drug delivery systems, with significant advantages over traditional drug nanocarriers. This is attributed to the unique structure and surface properties of the MSNs, their controllable sizes, tailored mesopore structures, as well as faile functionalization procedures for the design and fabrication of targeted drug delivery nanosystems. ,, Particle size tuning and surface modification are two important criteria in the design and fabrication of effective drug delivery systems for circumventing the BBB. , Results of the present work showed that the size of the MSNs was adjustable. In addition, TAT modification was easily performed in two steps (Figure ).…”

Section: Introductionmentioning

confidence: 74%

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Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring

et al. 2023

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The blood–brain barrier (BBB) acts as a physical/biochemical barrier that protects brain parenchyma from potential hazards exerted by different xenobiotics found in the systemic circulation. This barrier is created by “a lipophilic gate” as well as a series of highly organized influx/efflux mechanisms. The BBB bottleneck adversely affects the efficacy of chemotherapeutic agents in treating different CNS malignancies such as glioblastoma, an aggressive type of cancer affecting the brain. In the present study, mesoporous silica nanoparticles (MSNs) were conjugated with the transactivator of transcription (TAT) peptide, a cell-penetrating peptide, to produce MSN-NH-TAT with the aim of improving methotrexate (MTX) penetration into the brain. The TAT-modified nanosystem was characterized by Fourier transform infrared spectrometry (FTIR), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS), and N2 adsorption–desorption analysis. In vitro hemolysis and cell viability studies confirmed the biocompatibility of the MSN-based nanocarriers. In addition, in vivo studies showed that the MTX-loaded MSN-NH-TAT improved brain-to-plasma concentration ratio, brain uptake clearance, and the drug’s blood terminal half-life, compared with the use of free MTX. Taken together, the results of the present study indicate that MSN functionalization with TAT is crucial for delivery of MTX into the brain. The present nanosystem represents a promising alternative drug carrier to deliver MTX into the brain via overcoming the BBB.

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Section: Results and Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 74%

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Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring

et al. 2023

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“…PLGA exhibits the characteristic peak at 1745 cm –1 assigned to CC bonds, which is also present in both C1 and C2 particles. RIV exhibits peaks at 1727 cm –1 and at 1409 and 1462 cm –1 , which are attributed to the carboxyl group of the ester bond and the tensile absorptions of CC bonds in the aromatic ring, respectively . The spectrum of NAC shows a peak at 2549 cm –1 , which corresponds to the S–H stretching vibration .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives. Rivastigmine (RIV) and N-acetyl-cysteine (NAC) were coformulated via electrohydrodynamic atomization (EHDA), and they were incorporated into the PLGA particles. The two actives are administered as a combined therapy for Alzheimer’s disease. The printed arrays were evaluated regarding their ability to penetrate skin and their mechanical properties. Optical microscopy and scanning electron microscopy (SEM) were employed to further characterize the microneedle structure. Confocal laser microscopy studies were conducted to construct 3D imaging of the coating and to simulate the diffusion of the particles through artificial skin samples. Permeation studies were performed to investigate the transport of the drugs across human skin ex vivo. Subsequently, a series of tape strippings were performed in an attempt to examine the deposition of the APIs on and within the skin. Light microscopy and histological studies revealed no drastic effects on the membrane integrity of the stratum corneum. Finally, the cytocompatibility of the microneedles and their precursors was evaluated by measuring cell viability (MTT assay and live/dead staining) and membrane damages followed by LDH release.

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“…Notably, these ligands were more efficient than the transferring molecules, which would be considered an excellent choice for delivering the theranostics to the brain through the blood–brain barrier. Recently, polysorbate 80-immobilized, calcium-doped MSNs were employed to deliver rivastigmine to brain [ 330 ]. These nanosystems with excellent compatibility in blood and brain cells presented improved pharmacokinetics, exhibiting better brain uptake clearance of the designed nanocomposites compared to free drug.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

et al. 2022

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Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs often suffer from various limitations in biomedicine, such as reduced drug encapsulation efficacy, deprived compatibility, and poor degradability, resulting in poor therapeutic outcomes. To address these limitations, several modifications have been corroborated to fabricating hierarchically-engineered MSNs in terms of tuning the pore sizes, modifying the surfaces, and engineering of siliceous networks. Interestingly, the further advancements of engineered MSNs lead to the generation of highly complex and nature-mimicking structures, such as Janus-type, multi-podal, and flower-like architectures, as well as streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant to these advanced hierarchical architectures in different fields of biomedicine, including drug delivery, bioimaging, tissue engineering, and miscellaneous applications, such as photoluminescence, artificial enzymes, peptide enrichment, DNA detection, and biosensing, among others. Initially, we give a brief overview of diverse, innovative stimuli-responsive (pH, light, ultrasound, and thermos)- and targeted drug delivery strategies, along with discussions on recent advancements in cancer immune therapy and applicability of advanced MSNs in other ailments related to cardiac, vascular, and nervous systems, as well as diabetes. Then, we provide initiatives taken so far in clinical translation of various silica-based materials and their scope towards clinical translation. Finally, we summarize the review with interesting perspectives on lessons learned in exploring the biomedical applications of advanced MSNs and further requirements to be explored. Graphical Abstract

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Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery

Cited by 22 publications

References 93 publications

Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring

Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

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