In order to investigate the interfacial tuning mechanism of electronic skin (e-skin), several models of the capacitive pressure sensors (CPS) with different microstructures and several sizes of microstructures are constructed through finite element analysis method. The simulative pressure response, the sensitivity, and the linearity of the designed CPS show that the sensor with micropyramids has the best performance in all the designed models. The corresponding theoretically predicted sensitivity is as high as 6.3 × 10−7 fF/Pa, which is about 49 times higher than that without any microstructure. Additionally, these further simulative results show that the smaller the ratios ofL/Hof pyramid, the better the sensitivity but the worse the linearity. When the ratio ofL/Hof pyramid is about2, the sensitivity and the linearity could reach a balance point. The simulative results evidently provide the important theoretically directive significance for the further development ofe-skin.