Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish

Rieger, Sandra; Volkmann, Katrin; Köster, Reinhard W.

doi:10.1002/dvdy.21410

Cited by 28 publications

(38 citation statements)

References 58 publications

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“…This is related to their role in increasing neuronal plasticity and migration in embryonic vertebrates (reviewed in [32]. The ST8Sia II gene seems to have conserved the early development stage specific expression among vertebrates, while the ST8Sia IV gene has a more extended one, from later stages to adulthood in mammals, but at low level whatever the developmental stage in zebrafish [23,33]. Expression of an orthologous ST8Sia II gene in zebrafish has been previously described in a high-throughput analysis (accessible on line, (ZFIN database at http://zfin.org) [39]) and thus ST8Sia II ISH was not repeated in these data set.…”

Section: Discussionmentioning

confidence: 98%

“…As mentioned previously by Bentrop et al [46], the ST8Sia III mRNA was also localized in the retina of the developing eye at 48 hpf and this expression is restricted to the inner cell layer of retina at the larval stage (5 dpf). Several sialylated glycoproteins such as PSA N-CAM or the sialoprotein associated with cones and rods (SPACR) expressed in the retina of fish [21,23,48], rodents [49,50] or birds [51] might be the acceptor substrates for the ST8Sia III activity. Finally, no expression of the zebrafish ST8Sia III gene could be detected in the trunk, which is in contrast to the observation made by Bentrop et al [46] of an intense expression of this gene between 20 hpf and 32 hpf in the fast muscle fibres of the entire myotome.…”

Section: Discussionmentioning

confidence: 99%

“…Expression of the zebrafish polysialyltransferases ST8Sia II and ST8Sia IV genes has been described [23,33,39]. In a previous study, Thisse et al 2001 reported an early onset expression of the ST8Sia II gene at 10 hpf in the neural keel, which correspond to presumptive central nervous system (direct data submission in ZFIN [39]).…”

Section: Molecular Cloning Sequencing and Expressionmentioning

confidence: 96%

“…Both enzymes are expressed in the NS of most vertebrates where they catalyze the transfer of hundreds of sialic acid residues mainly on the N-glycans of N-CAM (reviewed in [31]) resulting in an increased neuronal plasticity and migration in embryonic vertebrate embryos (reviewed in [32]). ST8Sia II expression seems to be restricted to the early development stages among vertebrates, while ST8Sia IV has a more extended expression, from later development stages to adulthood in mammals, but at low level whatever the stage in zebrafish [23,33].…”

Section: Introductionmentioning

confidence: 94%

“…In the NS of the developing zebrafish, PSA is transiently formed on N-CAM, where it acts in guiding outgrowing axons [21]. Furthermore, in mature brain, PSA N-CAM has been implicated in regulating adult neurogenesis [22] and in adult zebrafish brain it regulates cerebellar neuronal plasticity [23]. Di-and oligo-sialic acid containing glycoproteins have been known for a while [24] and Sato et al have demonstrated that α2-8-linked diSialic acid (diSia) motifs occur in several glycoproteins of mammalian brain [14] among which CD-166, which appears to be involved in neurite formation in the Neuro2A mouse neuroblastoma cell line [25].…”

Section: Introductionmentioning

confidence: 99%

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Molecular cloning and characterization of the expression pattern of the zebrafish α2, 8-sialyltransferases (ST8Sia) in the developing nervous system

Chang

Mir²,

Thisse³

et al. 2008

Glycoconj J

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Sialyltransferases are Golgi type II transmembrane glycoproteins involved in the biosynthesis of sialylated glycolipids and glycoproteins. These sialylated compounds play fundamental roles in the development of a variety of tissues including the nervous system. In this study, we have molecularly cloned from zebrafish sources, the orthologues of the six human alpha2,8-sialyltransferases (ST8Sia), a family of sialyltransferases implicated in the alpha2-8-mono-, oligo-, and poly-sialylation of glycoproteins and gangliosides and we have analysed their expression pattern in the embryonic zebrafish nervous system, using in situ hybridization. Our results show that all six ST8Sia exhibit distinct and overlapping patterns of expression in the developing zebrafish central nervous system with spatial and temporal regulation of the expression of these genes, which suggests a role for the alpha2-8-sialylated compounds in the developing nervous system.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Molecular Cloning Sequencing and Expressionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molecular cloning and characterization of the expression pattern of the zebrafish α2, 8-sialyltransferases (ST8Sia) in the developing nervous system

Chang

Mir²,

Thisse³

et al. 2008

Glycoconj J

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Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid‐expressing Müller glia

Kustermann

Hildebrandt

Bolz

et al. 2009

J of Comparative Neurology

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Polysialic acid (polySia) is a posttranslational modification of the neural cell adhesion molecule NCAM, which in the vertebrate brain is dynamically regulated during development and crucially involved in developmental and adult neurogenesis. In the fish retina, new neurons are persistently generated, but the possible contribution of polySia has not yet been addressed. Here we used immunohistochemistry with NCAM- and polySia-specific antibodies to study spatiotemporal expression patterns of NCAM and polySia in the developing and mature zebrafish retina. As early as 2.3 days postfertilization (dpf), NCAM but not polySia was detected on cell somata and fibers of the developing retina. At 4.3 dpf polySia immunoreactivity first appeared in the ventral retina and was localized to the nascent outer nuclear layer (ONL). In mature zebrafish, polySia immunoreactivity in the ONL extended to the entire retina. Colocalization with rhodopsin-EGFP in transgenic zebrafish or the Müller glia-specific protein cellular retinaldehyde-binding protein (CRALBP) revealed that polySia immunoreactivity was confined to the compartment of radial Müller glia processes crossing the ONL and to a small band of processes positioned proximal to the horizontal cell layer of the mature retina. As shown by 5-bromo-2-deoxyuridine (BrdU) labeling, both newly generated rod precursors within the mature ONL and precursors of the marginal zone were polySia-negative. Thus, polySia-negative rod precursors of the mature zebrafish retina face a polySia-NCAM-positive microenvironment presented by radial Müller glia. In view of the prominent role of polySia in other neurogenic systems, this pattern indicates that polySia provides environmental cues that are relevant for the generation of new rods.

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The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long‐distance migration in an evolutionary conserved manner

Volkmann

Chen

Harris

et al. 2010

J of Comparative Neurology

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The upper rhombic lip (URL) of the developing mammalian cerebellum produces different neuronal cell types in a temporal sequence. The first neuronal populations arising from this proliferation zone include the progenitors of the parabrachial, parabigeminal, and laterodorsal-pedunculopontine tegmental hindbrain nuclei. By means of expression analysis, histology, and retrograde neuronal tracing, we have identified the zebrafish homologues of these nuclei, namely, the secondary gustatory/viscerosensory nucleus, the nucleus isthmi, and the superior reticular nucleus, respectively, in the embryonic and larval brain of a stable transgenic wnt1:Gal4-VP16-14 x UAS:GFP zebrafish strain. Combining time-lapse confocal imaging with individual cell tracing, we characterize the migratory behavior of these neuronal precursor populations in detail by revealing their migration path, velocity, and directionality. In addition, we identify neuronal progenitors of the secondary gustatory/viscerosensory nucleus and nucleus isthmi/superior reticular nucleus as belonging to the polysialic acid (PSA)-expressing cell population in the cerebellar plate that migrates in a PSA-dependent manner. Finally, we reveal that circuitries involved in the processing of sensory information (visual, gustatory, general viscerosensory) are already established in the zebrafish larva at day 4 of development. Also the wnt1-expressing pretectal neuronal precursors (not originating from the URL) sending mossy fiber-like projections into the cerebellar corpus are established at that time. In sum, our results show that the origin of neurons of some tegmental hindbrain nuclei, namely, nucleus isthmi/superior reticular nucleus and secondary gustatory/viscerosensory nucleus is in the URL, and that the temporal order of cell types produced by the URL and their developmental program are conserved among vertebrate species.

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Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish

Cited by 28 publications

References 58 publications

Molecular cloning and characterization of the expression pattern of the zebrafish α2, 8-sialyltransferases (ST8Sia) in the developing nervous system

Molecular cloning and characterization of the expression pattern of the zebrafish α2, 8-sialyltransferases (ST8Sia) in the developing nervous system

Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid‐expressing Müller glia

The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long‐distance migration in an evolutionary conserved manner

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