Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat

Tabandeh, Mohammad Reza; Oryan, Ahmad; Mohammadalipour, Adel

doi:10.1016/j.ijbiomac.2014.01.055

Cited by 78 publications

(39 citation statements)

References 27 publications

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“…The possible mechanisms by which the gel helped WH included keeping the wound moist, increased epithelial cell migration, more rapid maturation of collagen, and reduction in inflammation; increased collagen synthesis; increase in synthesis of hyaluronic acid and dermatan sulfate in the granulation tissue of the healing wound, and increased blood supply as a result of improved oxygenation . Mannose rich polysaccharides of Aloe vera Mill gel enhanced TIMP‐2 gene expression, collagen, n ‐acetyl galactosamine and n ‐acetyl glucosamine synthesis during the skin wound repair of rats . Although Aloe vera Mill is an outstanding example of well‐studied wound‐healing plant, many of its active phytochemicals have not been identified yet.…”

Section: Medicinal Plants Of the World Flora With Wh Activitymentioning

confidence: 99%

Effect of medicinal plants on wound healing

Budovsky

Yarmolinsky

Ben‐Shabat

2015

Wound Repair Regeneration

139

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Nowadays, owing to drastic changes in social conditions, people are increasingly becoming stressed. Consequently, the number of people who want to be healed is also increasing. In this study, we focused on the use of plants to reduce stress. We develop a pseudo-communication system with plants using 7 sensors (for temperature, humidity, CO 2 , and so on), a microphone, and a display. The system will have healing effects such as those of counselors or animal-assisted therapy. Then, a communication experiment is carried out to confi rm that the proposed system can reduce user's stress. As a result, from amylase activity, it is found that user stress is reduced when the user uses the system when stressed. Therefore, it is clear that the proposed communication system has some healing effect on stressed users.

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Section: Medicinal Plants Of the World Flora With Wh Activitymentioning

confidence: 99%

Effect of medicinal plants on wound healing

Budovsky

Yarmolinsky

Ben‐Shabat

2015

Wound Repair Regeneration

139

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“…Estas características han hecho que sea blanco de investigaciones por su acción antimicrobiana, antiviral, antifúngica y antiinflamatoria en procesos de curación de heridas (51)(52)(53).…”

Section: Discussionunclassified

Evaluación de extractos vegetales para manejo de quemaduras cáusticas: irritación/corrosión dérmica aguda. Bogotá/2018

Céspedes

Ospina

Vargas³

et al. 2018

rev cuarzo

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Londoño Valero10, Laura del Mar Lozada Cruz10 Licencia creative commons ResumenIntroducción: Aunque las quemaduras cáusticas representan un bajo porcentaje de las quemaduras, dadas las complicaciones que asocian, son un problema de salud pública que exige nuevas opciones terapéuticas como son el uso de productos derivados de plantas, entre ellos, Calendula offinalis, Aloe vera y Cannabis sativa, cuyo uso está condicionado, inicialmente a pruebas como la evaluación de su efecto irritativo/corrosivo agudo en piel. Materiales y métodos:Estudio experimental en animales, aleatorizado. El material vegetal se obtuvo del Jardín Medicinal Jorge Piñeros Corpas; los aceites y extractos de las plantas se obtuvieron por métodos clásicos de extracción; la base de excipientes fue provista por el Laboratorio de Farmacología Vegetal (LABFARVE). Se emplearon 8 Ratas wistar macho alojadas bajo condiciones controladas y parámetros de ética y bienestar animal. La prueba de irritación/corrosión dérmica aguda se hizo siguiendo la norma OECD 404, tras previa anestesia de los animales y siguiendo los criterios de dolor y punto final.Resultados: De Calendula officinalis se obtuvieron dos aceites esenciales y tres extractos; el gel de Aloe vera y un extracto de Cannabis sativa. Ninguno de los extractos generó escara, eritema o edema en los animales, siendo negativa la prueba de irritación/corrosión aguda en piel.Discusión: Los resultados obtenidos desde esta investigación básica en medicina traslacional, brindan evidencia que complementa la información reportada en la literatura acerca del uso tradicional y los estudios in vitro e in vivo de estas plantas para el manejo de diversas enfermedades. La ausencia de efecto irritativo o corrosivo en piel es coherente con el conocimiento del tipo de metabolitos secundarios activos que se han identificado en ellas con actividad antiinflamatoria, antioxidante, antimicrobiana y cicatrizante. Los resultados aseguran su inocuidad química al contemplarlas para investigar su potencial uso terapéutico en lesiones dérmicas, tipo quemaduras cáusticas, garantizando su seguridad . AbstractIntroduction: Considering that caustic burns represent a low percentage of burns, given the complications they could associate, they are a public health problem that requires new therapeutic options such as the use of plant-derived products, including Calendula offinalis, Aloe vera and Cannabis sativa, whose use is conditioned, initially to tests such as the evaluation of its acute irritative / corrosive effect on skin.

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“…[93,94] Polysaccharides of Aloe A. vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of the rat. [95] A. vera gel is also used as decontamination agent during wound healing. [96,97] A. vera influences water absorption and enzymatic degradation of alginate hydrogel films.…”

Section: Anti-inflammatorymentioning

confidence: 99%

“…[56,94,98] Polysaccharides of A. vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. [95] A. vera extract is used to prepare decontaminant and wound healing formulation to treat sulfur mustard-induced skin injury. [96] Microparticles of A. vera/Vitamin E/chitosan are used in nuclear imaging and an in vivo test analysis for burn treatment.…”

Section: Anti-inflammatorymentioning

confidence: 99%

Untitled

Upadhyay¹

2018

IJGP

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The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-known plant grows in semi-arid climate of tropical and subtropical regions. This article emphasizes important uses of A. vera constituents as dietary nutraceutical, medicinal, and therapeutic potential. Plant is cultivated for agricultural and medicinal and decoration purposes for indoors as a potted plant. Plant is a good depository of chemical constituents which display a very wide array of biological activities such as anticancer, antiparasitic, antidiabetic, anti-inflammatory, anti-arthritic, antiparasitic, antitumor, antioxidant, chemopreventive, hepatoprotective, and gastroprotective. Plant is used to prepare skin protective/care gels mainly for soothing, moisturizing, and wound healing. Thick watery plant sap works are added as key ingredient in many beauty products. Plant leaves are used to generate aroma, beverages, skin lotion, cosmetics, or ointments for minor burns. Plant contains vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids, and amino acids as main ingredients. Plant is a good source of Vitamins A, C, and E, which are antioxidants. It also contains Vitamin B12, folic acid, and choline watery juicy of A. vera leaf which contains important minerals such as calcium, chromium, copper, selenium, magnesium, manganese, and potassium. Plant ingredients were found active against gingivitis, psoriasis, and used for herbal therapy in inflammatory bowel disease. A. vera contains important fatty acids mainly steroids such as cholesterol, campesterol, β-sitosterol, and lupeol. Aloin and emodin act as analgesics, antibacterials, and antivirals while lupeol shows antiseptic and analgesic properties. It also contains auxins and gibberellin hormones that help in wound healing and have anti-inflammatory action. Saponins that are the soapy substances display cleansing and antiseptic properties.

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Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat

Cited by 78 publications

References 27 publications

Effect of medicinal plants on wound healing

Effect of medicinal plants on wound healing

Evaluación de extractos vegetales para manejo de quemaduras cáusticas: irritación/corrosión dérmica aguda. Bogotá/2018

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