Polysaccharides in colon-specific drug delivery

Sinha, Vivek Ranjan; Kumria, Rachna

doi:10.1016/s0378-5173(01)00720-7

Cited by 759 publications

(397 citation statements)

References 104 publications

Supporting

Mentioning

374

Contrasting

Unclassified

Order By: Relevance

“…Chitosan, obtained from crab exoesquelets, has several polar groups such as -OH and -NH 2 which can act as electron donors. Whereas alginates have been largely employed in drug delivery systems, there is increased interest in studying chitosan for its biological applications due to its mucous adhesiveness, no toxicity, biocompatibility and biodegradability (Sinha and Kumria 2001). Chitosan and alginate can react together by coacervation due to their opposite charges.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of liquid smoke flavoring in ca-alginate and ca-alginate-chitosan beads

et al. 2013

View full text Add to dashboard Cite

Encapsulation is a technique used in foods that may protect some compounds with sensory impact, in particular flavoring as liquid smoke. We used the dripping method, obtaining two different layers for encapsulation of liquid smoke: calcium alginate and calcium alginate-chitosan. The results show that the load capacity of liquid smoke encapsulation reached values above 96 %. The beads exhibit syneresis at room temperature, but in opposite side, refrigeration temperature stabilizes the hydrogel of beads, allowing the samples loss weight less than 3 % after 72 h. Heated capsules with liquid smoke released several volatile compounds in the headspace and may identify 66 compounds. Among these volatile compounds, phenols derivatives can be considered sensory descriptors to contribute to the specific flavor of smoke. We conclude that the dripping method is highly efficient to encapsulate liquid smoke and released several volatile compounds, although it is necessary to minimize syneresis at room temperature.

show abstract

Section: Introductionmentioning

confidence: 99%

Encapsulation of liquid smoke flavoring in ca-alginate and ca-alginate-chitosan beads

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Also, natural polysaccharides have demanded particular interest due to their attractive biocompatible, biodegradable, hydrophilic and protecting properties, which have demonstrated favourable characteristics for drug entrapment and delivery [4]. However, due to the labile physicochemical properties of proteins, gentle nanoencapsulation conditions must be provided to assure the maintenance of their structural bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of new insulin containing polysaccharide nanoparticles

Sarmento

Ribeiro

Veiga

et al. 2006

Colloids and Surfaces B: Biointerfaces

226

140

View full text Add to dashboard Cite

A nanoparticle insulin delivery system was prepared by complexation of dextran sulfate and chitosan in aqueous solution. Parameters of the formulation such as the final mass of polysaccharides, the mass ratio of the two polysaccharides, pH of polysaccharides solution, and insulin theorical loading were identified as the modulating factors of nanoparticle physical properties. Particles with a mean diameter of 500 nm and a zeta potential of approximately −15 mV were produced under optimal conditions of DS:chitosan mass ratio of 1.5:1 at pH 4.8. Nanoparticles showed spherical shape, uniform size and good shelf-life stability. Polysaccharides complexation was confirmed by differential scanning calorimetry and Fourier transformed infra-red spectroscopy. An association efficiency of 85% was obtained. Insulin release at pH below 5.2 was almost prevented up to 24 h and at pH 6.8 the release was characterized by a controlled profile. This suggests that release of insulin is ruled by a dissociation mechanism and DS/chitosan nanoparticles are pH-sensitive delivery systems. Furthermore, the released insulin entirely maintained its immunogenic bioactivity evaluated by ELISA, confirming that this new formulation shows promising properties towards the development of an oral delivery system for insulin.

show abstract

“…Pectins, starch, guar gum, amylase and karaya gum are a few polysaccharides commonly used in dosage forms. Non -starch, linear polysaccharides remain intact in the physiological environment of the stomach and the small intestine, but are degraded by the bacterial inhabitants of the human colon which make them potentially useful in targeted delivery systems to the colon [40].…”

Section: Polysaccharides In Pharmaceuticalsmentioning

confidence: 99%

Herbal excipients in Novel Drug Delivery Systems

Chavhan¹,

Shinde²,

Sapkal³

et al. 2017

IRJDPL

View full text Add to dashboard Cite

Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases, they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent trends towards use of plant based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural materials have many advantages over synthetic ones as they are chemically inert, nontoxic, less expensive, biodegradable, improve the shelf life of product and widely available. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery systems.

show abstract

Polysaccharides in colon-specific drug delivery

Cited by 759 publications

References 104 publications

Encapsulation of liquid smoke flavoring in ca-alginate and ca-alginate-chitosan beads

Encapsulation of liquid smoke flavoring in ca-alginate and ca-alginate-chitosan beads

Development and characterization of new insulin containing polysaccharide nanoparticles

Herbal excipients in Novel Drug Delivery Systems

Contact Info

Product

Resources

About