Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition

Abstract

Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition.

Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta‐analysis

“…reported a maintained or decreased granulocytes/lymphocytes ratio during follow‐up and supposed lentinan may increase the cellular response. Findings from latest basic cell and animal researches of lentinan in vitro and in vivo primary elucidated direct anticancer effects and immune modifying effects: (1) lentinan alone inhibits cancer cell proliferation and induce cell apoptosis ; (2) a combination of lentinan with chemotherapy drugs or monoclonal antibodies enhances their toxicity to cancer cell ; (3) lentinan can be blinding to activate macrophages and other monocytes . Anticancer effects were found to be mainly p53‐dependent, and involved MAPK signaling pathways activation and reactive oxygen species overproduction ; and immune modifying effects of lentinan mainly because of its activation of macrophages and monocytes though binding to specific receptors on the cells, and further induction of cytokine release, complement activation, and antibody‐dependent cell‐mediated cytotoxicity .…”

Streaky, whiplash‐like erythema and succulent papules: flagellate dermatitis following consumption of Auricularia auricula‐judae

“…Apoptosis was confirmed by the rapid stimulation of the production of reactive oxygen species, a loss of mitochondrial membrane potential, and an increase in intracellular Ca 2+ levels [7]. Mouse models have shown that polysaccharides derived from LE inhibit tumor growth and 5-FU production [8]. Furthermore, serum levels of TNFalpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8 + T cells in the spleen, and splenic NK and CTL activities were significantly increased in these mouse models [8].…”

“…Mouse models have shown that polysaccharides derived from LE inhibit tumor growth and 5-FU production [8]. Furthermore, serum levels of TNFalpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8 + T cells in the spleen, and splenic NK and CTL activities were significantly increased in these mouse models [8]. These effects of polysaccharides derived from LE may also be involved in the pathophysiology of shiitake dermatitis.…”

Streifiges, peitschenhiebähnliches Erythem und sukkulente Papeln: Flagellaten‐Dermatitis nach Verzehr von Auricularia auricula‐judae

“…In Mausmodellen inhibieren LE-Polysaccharide nachweislich das Tumorwachstum und die 5-FU-Produktion [8]. Darüber hinaus stiegen in diesen Mausmodellen die Serumspiegel von TNF-alpha, Il-2 und IFN-gamma, die Anzahl von CD4+ und CD8+ T-Zellen in der Milz und die Aktivitäten von NK-und CTL-Zellen deutlich an [8]. Diese Effekte der LE-Polysaccharide könnten auch bei der Pathophysiologie der Shiitake-Dermatitis eine Rolle spielen.…”