Polysaccharides from Polygonatum odoratum strengthen antioxidant defense system and attenuate lipid peroxidation against exhaustive exercise-induced oxidative stress in mice

Yang, Hongjie; Zhang, Xianhao

doi:10.4314/tjpr.v16i4.8

Cited by 18 publications

(4 citation statements)

References 30 publications

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“…Generally, antioxidants clear all free radicals; therefore, an increase in antioxidant consumption can affect a variety of pathways, including cellular signaling pathways that are important for adaptation to exercise (McLeay et al, 2017). Studies in humans and mice have shown that feeding antioxidant vitamins has a positive effect on lipid peroxidation after exercise (Sari- Sarraf et al, 2016;Yang and Zhang, 2017). For example, Şentürk et al (2001) examined the effect of vitamin C and E supplementation on high lipid peroxidation, which is caused by acute exhaustive running exercise in rats.…”

Section: Discussionmentioning

confidence: 99%

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats

Kayacan¹,

Kisa²,

Ghojebeigloo³

et al. 2019

Acta Neurobiologiae Experimentalis

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Regular exercise and amino acid supplementation, popular approaches toward the reduction of epileptic seizures, have been extensively researched. This study was conducted to evaluate the effects of treadmill exercise and L-tyrosine treatment on the frequency and amplitude of epileptiform activity in rats. A total of 32 male albino Wistar rats were randomly divided into four groups: control, exercise, L-tyrosine, and exercise + L-tyrosine. L-tyrosine was supplemented by oral gavage (500 mg/kg/day, 2.5 mL solution).The treatments were performed 5 days a week for 10 weeks. The rats were anesthetized and then administered 500 IU penicillin into the left cerebral cortex using a microinjector and electrocorticogram (ECoG) activity was recorded for 3 hours using a Power Lab data acquisition system. The frequency and the amplitude of the ECoG recordings were analyzed offline. Compared to the control group, spike frequency decreased significantly in all other groups. There was no statistically significant difference between the groups in terms of spike amplitude and latency. In this study, the effects of regularly administered treadmill exercise and L-tyrosine use on epileptiform activity were examined and evaluated together for the first time. The results of this study showed that regular exercise and L-tyrosine use decreased epileptiform activity. Further research and clinical trials are needed to investigate the extent to which L-tyrosine and physical activity interfere with the epileptic state by investigating different doses of L-tyrosine and different severity/ time/type of exercise protocols.

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Section: Discussionmentioning

confidence: 99%

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats

Kayacan¹,

Kisa²,

Ghojebeigloo³

et al. 2019

Acta Neurobiologiae Experimentalis

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show abstract

“…In addition, the power of chelating Fe 2+ was up to 98.721%, which is in sharp contrast with other components. Polygonatum odoratum , similar to Polygonatum sibiricum , is also a Liliaceae plant with an antioxidant capacity [ 72 ]. For example, studies have explored the effect of polysaccharides isolated from Polygonatum odoratum (PPO) on oxidative stress induced by fatigue exercise.…”

Section: Antioxidant Activity Of Natural Polysaccharidesmentioning

confidence: 99%

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

Bai

Zhou

et al. 2022

Antioxidants

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Many chronic diseases such as Alzheimer’s disease, diabetes, and cardiovascular diseases are closely related to in vivo oxidative stress caused by excessive reactive oxygen species (ROS). Natural polysaccharides, as a kind of biomacromolecule with good biocompatibility, have been widely used in biomedical and medicinal applications due to their superior antioxidant properties. In this review, scientometric analysis of the highly cited papers in the Web of Science (WOS) database finds that antioxidant activity is the most widely studied and popular among pharmacological effects of natural polysaccharides. The antioxidant mechanisms of natural polysaccharides mainly contain the regulation of signal transduction pathways, the activation of enzymes, and the scavenging of free radicals. We continuously discuss the antioxidant activities of natural polysaccharides and their derivatives. At the same time, we summarize their applications in the field of pharmaceutics/drug delivery, tissue engineering, and antimicrobial food additives/packaging materials. Overall, this review provides up-to-date information for the further development and application of natural polysaccharides with antioxidant activities.

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“…To the best of our knowledge, there have been a few studies that have evaluated the bioactivity of P. odoratum polysaccharides, of which polysaccharides fractions isolated from P. odoratum rhizome were shown to exhibit hypoglycemic, anti-oxidative, anti-microbial, and immunoregulatory activities, as well as the ability to modulate gut microbiota [8][9][10][11][12][13][14]. Pectin is detected in the rhizome of P. odoratum, but despite its high abundance, its structural composition remains largely unknown [15].…”

Section: Introductionmentioning

confidence: 99%

Structural Compositions and Biological Activities of Cell Wall Polysaccharides in the Rhizome, Stem, and Leaf of Polygonatum Odoratum (Mill.) Druce

Li,

Hsiung,

Kao

et al. 2022

SSRN Journal

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Polysaccharides from Polygonatum odoratum strengthen antioxidant defense system and attenuate lipid peroxidation against exhaustive exercise-induced oxidative stress in mice

Cited by 18 publications

References 30 publications

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

Structural Compositions and Biological Activities of Cell Wall Polysaccharides in the Rhizome, Stem, and Leaf of Polygonatum Odoratum (Mill.) Druce

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