Polysaccharides from Pinus massoniana pollen improve intestinal mucosal immunity in chickens

Progress of Studies on Plant-Derived Polysaccharides Affecting Intestinal Barrier Function in Poultry

“…It was found that adding 0.6 g/L APS to drinking water significantly increased the content of sIgA in the ileum of Muscovy duck reovirus-infected young Muscovy ducks [ 15 ]. Except for APS, oral administration of 20 and 40 mg/mL Pinus massoniana pollen polysaccharides could also increase the secretion of intestinal sIgA content in broilers [ 50 ]. In addition, Wang et al [ 48 ] reported that injection of 10, 20 and 40 mg/mL Paulownia fortunei flower polysaccharides into the neck of broilers promoted sIgA secretion in the duodenum caused by cyclophosphamide.…”

“…Liao et al [ 15 ] also found that adding 0.6 g/L Astragalus polysaccharides to drinking water could effectively restore VH and improve V/C ratio in the small intestine, thus alleviating small intestine damage in Muscovy ducks infected with Muscovy reovirus. Moreover, Sha et al [ 50 ] reported that oral administration of Pinus massoniana pollen polysaccharides at 10–40 mg/mL could effectively promote the healthy development of intestinal villi in broilers, but there was no significant difference between the 20 mg/mL and 40 mg/mL dose groups, suggesting that the promoting effect of Pinus massoniana pollen polysaccharides was not always presented in a dose-dependent manner. Except for injection and drinking water, most researchers used the method of mixing plant-derived polysaccharides into poultry basal diets.…”

“…In the intestinal immune barrier, intestine-associated lymphoid tissue plays an important role, among which lymphocytes and macrophages play a crucial role in the process of resistance to pathogen invasion. It has been reported that oral administration of 10, 20, and 40 mg/mL Pinus massoniana pollen polysaccharides to broilers, compared with the PBS group, promoted the transformation rate of CD4+ and CD8+ T lymphocytes and the gene expression of intestinal mucosal cytokines IL-2, IL-4 and IFN-γ [ 50 ]. Liao et al [ 15 ] found that the supplementation with 0.6 g/L Astragalus polysaccharides in drinking water effectively inhibited the reduction of intraepithelial lymphocytes and goblet cells caused by reovirus infection in Muscovy ducks, increased the secretion of IL-15, and brought the levels of TNF-α and IFN-γ to normal levels, thus alleviating the damage of the immune barrier in the small intestinal mucosa of Muscovy ducklings and effectively improving the immune function of the intestinal mucosa.…”

Effects of Alhagi camelorum Fisch polysaccharide from different regions on growth performance and gastrointestinal microbiota of sheep lambs

“…This plant is a valuable traditional medicine known for its efficacy in treating conditions such as abdominal distension, abdominal pain, oral ulcers, and hemoptysis ( Li et al, 2018 ). The primary chemical components of Alhagi camelorum Fisch plant include polysaccharides, flavonoids, alkaloids, sterols, fats, and amino acids, among others ( Sha et al, 2021 ). Studies have indicated that Alhagi camelorum Fisch polysaccharides (AP) can stimulate the release of TNF-α, IL-1β, and IL-12 cytokine in RAW264.7 macrophages.…”

Elemental composition of microstrobili and sprouts of <i>Pinus sylvestris, Pinus sibirica</i> and <i>Pinus pumila</i>

“…Исследователями отмечается [3], что за последние 20 лет наблюдается активизация фармакологических и клинических исследований сосновой пыльцы, о чем свидетельствует рост количества публикаций на эту тему. Установлены иммуномодулирующая, противовирусная, противовоспалительная, антиоксидантная и гепатопротекторная активности экстрактов [4][5][6][7] и полисахаридов [8][9][10][11][12] пыльцы азиатских видов сосен. Исследование пыльцы P. sylvestris и P. pumila, проведенное авторами ранее, показало содержание в ней флавоноидов, аминокислот, аскорбиновой кислоты, макро-и микроэлементов [13].…”