Polysaccharides from Codium Species

Fernández, Paula Virginia; Arata, Paula Ximena; Ciancia, Marina

doi:10.1016/b978-0-12-408062-1.00009-3

Cited by 26 publications

(15 citation statements)

References 77 publications

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“…Moreover, the sulfated polysaccharide in C. latum, C. pugniforme (syn. C. spongiosum),and C. vermilara were described as sulfated arabinan, sulfated glucan, and sulfated mannan, respectively (Bilan et al 2006;Fernández et al 2012Fernández et al , 2014. Sulfated galactans from C. fragile differs from the C. cylindricum.…”

Section: Sulfated Polysaccharidesmentioning

confidence: 99%

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

2022

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The genus Codium is one of the most important genera of marine green macroalgae. Its distribution is widespread worldwide and it has a high degree of diversity in species and characteristics. This genus plays an important ecological role in marine ecosystems as it is a primary producer. However, some species in the genus Codium are invasive species and may disturb the functioning of the ecosystem. Economically, Codium has promising potential as a source of diverse nutritional and pharmacological compounds. Codium is edible, has a high nutrient value, and is rich in bioactive compounds. Hence, some species of Codium have been consumed as food and used as herbal medicines in some Asian countries. In recent decades, studies of the bioactivity and pharmacological properties of the genus Codium have attracted the attention of scientists. This review aims to identify gaps in studies analyzing Codium that have been conducted in the past three decades by assessing published research articles on its bioactivity and pharmacological properties. Compounds obtained from Codium have demonstrated significant biological activities, such as immunostimulatory, anticoagulant, anticancer, anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, antitumor, anti-angiogenic, osteoprotective, and anti-obesity activities. This review provides information that can be used as a future guideline for sustainably utilizing the genus Codium.

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Section: Sulfated Polysaccharidesmentioning

confidence: 99%

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

2022

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“…Finally, these compounds also show immune-stimulating properties in both in vitro and in vivo models. Sulfated galactan obtained from C. fragile stimulated murine macrophages RAW264.7 cell line, increasing the levels of nitric oxide and both pro-inflammatory and anti-inflammatory cytokines, which are fundamental for the host immune response [ 81 , 82 , 83 ]. In head kidney cells, SPs had a stimulatory effect on immune genes, including interleukin (IL)-1β, IL-8, TNF-α, interferon (IFN)-γ, and lysozyme [ 84 ].…”

Section: Main Invasive Species Of Northwest Spain and Their Bioactive Compoundsmentioning

confidence: 99%

The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study

et al. 2021

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In the recent decades, algae have proven to be a source of different bioactive compounds with biological activities, which has increased the potential application of these organisms in food, cosmetic, pharmaceutical, animal feed, and other industrial sectors. On the other hand, there is a growing interest in developing effective strategies for control and/or eradication of invasive algae since they have a negative impact on marine ecosystems and in the economy of the affected zones. However, the application of control measures is usually time and resource-consuming and not profitable. Considering this context, the valorization of invasive algae species as a source of bioactive compounds for industrial applications could be a suitable strategy to reduce their population, obtaining both environmental and economic benefits. To carry out this practice, it is necessary to evaluate the chemical and the nutritional composition of the algae as well as the most efficient methods of extracting the compounds of interest. In the case of northwest Spain, five algae species are considered invasive: Asparagopsis armata, Codium fragile, Gracilaria vermiculophylla, Sargassum muticum, and Grateulopia turuturu. This review presents a brief description of their main bioactive compounds, biological activities, and extraction systems employed for their recovery. In addition, evidence of their beneficial properties and the possibility of use them as supplement in diets of aquaculture animals was collected to illustrate one of their possible applications.

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“…Sulfated PLS, one of the main classes of bioactive substances from marine algae, exhibit a wide range of pharmacological activities (Kouakou et al 2013;Cunha and Grenha 2016). These PLS have potential application in several fields of biomedicine, including pharmacology (Fernandez et al 2014). Here, we highlight their anti-inflammatory action (Batista et al 2014) and the ability to protect the gastrointestinal tract (Brito et al 2014) and prevent oxidative damage in living organisms (Wang et al 2008).…”

Section: Introductionmentioning

confidence: 97%

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

Monturil

Brito

Júnior

et al. 2020

Rev. Bras. Farmacogn.

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Sulfated polysaccharides derived from seaweeds have important biological activities. The aim of this work was to demonstrate the anti-inflammatory effect of a sulfated polysaccharide extracted from the seaweed Digenea simplex (Wulfen) C. Agardh 1822 on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. After inducing colitis, rats were euthanized, and the colon was excised to determine macroscopic lesion scores and wet weight and to histologically evaluate and quantify glutathione, malondialdehyde, myeloperoxidase, nitrate/nitrite, and cytokines. The polysaccharide, composed of β-D-galactose and 3,6-α-L-anhydrogalactose residues, reduced wet weight as well as macroscopic and microscopic lesion scores. It also reduced myeloperoxidase activity; reduced proinflammatory cytokines, malondialdehyde, and nitrate/nitrite levels; and preserved glutathione consumption in the colon. According to these results, we can infer that the sulfated polysaccharide derived from D. simplex has an anti-inflammatory effect on induced colitis in vivo.

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Polysaccharides from Codium Species

Cited by 26 publications

References 77 publications

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

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