Polysaccharides catabolism by the human gut bacterium -<i>Bacteroides thetaiotaomicron</i>: advances and perspectives

Ye, Meng; Yu, Juping; Shi, Xuexia; Zhu, Junkai; Gao, Xiangdong; Liu, Wei

doi:10.1080/10408398.2020.1803198

Cited by 42 publications

(28 citation statements)

References 170 publications

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“…Possible patterns for the degradation of sulfated polysaccharides by gut microbiota. (a) Model of CS degradation by B. thetaiotaomicron (Ye et al., 2020). (b) Model of SPs degradation based on the starch utilization system in B. thetaiotaomicron (Cockburn & Koropatkin, 2016).…”

Section: Sps and Gut Microbiotamentioning

confidence: 99%

“…Apart from the abovementioned well‐known beneficial bacteria, some other beneficial bacteria that are the major producers of SCFAs, such as Bacteroides and Alloprevotella , can also be enriched by SPs. Bacteroides thetaiotaomicron , a representative species of Bacteroides , contains various glycoside hydrolases (GHs) and polysaccharide lyases (PLs) such as glycosaminoglycan lyase, which is involved in the degradation of CS/HS (Ye et al., 2020). We found that the administration of various types of SPs in different experimental models could elevate the abundance of Bacteroides , such as FUC supplementation in C57BL/6J mice with HFD‐induced obesity (Shang, Song, et al., 2017) and in BALB/c mice with Cy‐induced intestinal mucosal injury (Shi et al., 2017); FCS fermented with the human gut microbiota in vitro (Mou et al., 2020) and supplemented in C57BL/6J mice with HFD‐induced obesity (Hu, Wang, Xu, et al., 2019); and SCSP supplementation in normal BALB/c mice (Zhu, Zhu, Sun, Ai, Wu, et al., 2018) and in BALB/c mice with HFD‐induced obesity (Zhu, Zhu, Sun, Ai, Wang, et al., 2018).…”

Section: Sps and Gut Microbiotamentioning

confidence: 99%

“…However, the enzymes involved in the degradation of CSA have not been revealed. More in‐depth studies have allowed the establishment of a system for the effective degradation of CS/HS by Bacteroides thetaiotaomicron (Cartmell et al., 2017; Ndeh et al., 2020; Ye et al., 2020). For example, the PLs (BT3324, BT3350, and BT4410) of Bacteroides thetaiotaomicron could cleave CS to produce unsaturated disaccharides, esterases (BT1596 and BT3349) release sulfate groups from disaccharides, and GH (BT3348) further cleaves disaccharides to monosaccharides (Ndeh et al., 2020).…”

Section: Sps and Gut Microbiotamentioning

confidence: 99%

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Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

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Various dietary sulfated polysaccharides (SPs) have been isolated from seafoods, including edible seaweeds and marine animals, and their health effects such as antiobesity and anti‐inflammatory activities have attracted remarkable interest. Sulfate groups have been shown to play important roles in the bioactivities of these polysaccharides. Recent in vitro and in vivo studies have suggested that the biological effects of dietary SPs are associated with the modulation of the gut microbiota. Dietary SPs could regulate the gut microbiota structure and, accordingly, affect the production of bioactive microbial metabolites. Because of their differential chemical structures, dietary SPs may specifically affect the growth of certain gut microbiota and associated metabolite production, which may contribute to variable health effects. This review summarizes the latest findings on the types and structural characteristics of SPs, the effects of different processing techniques on the structural characteristics and health effects of SPs, and the current understanding of the role of gut microbiota in the health effects of SPs. These findings might help in better understanding the mechanism of the health effects of SPs and provide a scientific basis for their application as functional food.

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Section: Sps and Gut Microbiotamentioning

confidence: 99%

Section: Sps and Gut Microbiotamentioning

confidence: 99%

Section: Sps and Gut Microbiotamentioning

confidence: 99%

See 1 more Smart Citation

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

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“…In contrast, unfermentable polysaccharides will eventually be discharged as waste, and fermentable polysaccharides can be degraded by intestinal microorganisms and eventually absorbed and used by the human body ( Ahmadi et al, 2017 ). Previous research have pointed out some polysaccharides are required to be degradated by intestinal microorganisms for further utilization, such as resistant starch, levan, and mannan ( Ye et al, 2020 ). Among the identified intestinal microorganisms, some of them are thought to be able to utilize polysaccharides, which they degrade by producing the corresponding enzymes ( Bernalier-Donadille, 2010 ; Cockburn and Koropatkin, 2016 ), such as Bacteroides .…”

Section: Polysaccharides and The Effect Of Polysaccharides On Intesti...mentioning

confidence: 99%

Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression

Wang

Liu

et al. 2022

Front. Microbiol.

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The intestinal tract of a healthy body is home to a large variety and number of microorganisms that will affect every aspect of the host’s life. In recent years, polysaccharides have been found to be an important factor affecting intestinal flora. Polysaccharides are widely found in nature and play a key role in the life activities of living organisms. In the intestinal tract of living organisms, polysaccharides have many important functions, such as preventing the imbalance of intestinal flora and maintaining the integrity of the intestinal barrier. Moreover, recent studies suggest that gut microbes can influence brain health through the brain-gut axis. Therefore, maintaining brain health through polysaccharide modulation of gut flora deserves further study. In this review, we outline the mechanisms by which polysaccharides maintain normal intestinal flora structure, as well as improving cognitive function in the brain via the brain-gut axis by virtue of the intestinal flora. We also highlight the important role that gut microbes play in the pathogenesis of depression and the potential for treating depression through the use of polysaccharides to modulate the intestinal flora.

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“…Bacteroides thetaiotaomicron , Bacteroides uniformis , Bacteroides cellulosilyticus , Bacteroides vulgatus , Bacteroides ovatus , Bacteroides caccae , Bacteroides xylanisolvens , and Bacteroides dorei are the dominant species of the Bacteroides (Forster et al., 2019). Among them, B. thetaiotaomicron are considered as the best degrader of polysaccharides and potential probiotics in pharmaceutical and food industries (Ye et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome

Song

Zhang

et al. 2021

Food Frontiers

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The interaction between gut microbiota and polysaccharide is being paid more and more attention. Galactan is a kind of polysaccharide mainly composed of galactose, and it has been shown to play a significant role in regulating gut microbiota. Bacteroides thetaiotaomicron is considered as the best degrader of polysaccharides. The purpose of this paper was to investigate the utilization of four different galactans, including agarose, carrageenan, arabinogalactan, and glucofucogalactan, by our own isolated B. thetaiotaomicron A4. Samples of cultures grown on either four galactans groups or control groups were collected. The change of OD600, pH, and short‐chain fatty acids (SCFAs) during fermentation were determined, and growth curve and transcriptome of B. thetaiotaomicron A4 were studied. B. thetaiotaomicron A4 could utilize the four galactans and grew well on them, with carrageenan being most utilized, followed by arabinogalactan, glucofucogalactan, and agarose. SCFAs (mainly acetic acid and propionic acid) produced along with the decreased pH during fermentation. A large number of genes of B. thetaiotaomicron A4 were upregulated and functioned in different pathways during the degradation of the four galactans. The carbohydrate metabolism‐related pathways of B. thetaiotaomicron A4 were enriched after feeding the four galactans, although the specific pathways were different among four galactans groups. The different structural characteristics of four galactans required that B. thetaiotaomicron A4 could excrete corresponding enzymes to degrade them. These results help to understand the interaction between galactans and gut microbe.

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Polysaccharides catabolism by the human gut bacterium -Bacteroides thetaiotaomicron: advances and perspectives

Cited by 42 publications

References 170 publications

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression

Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome

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