“…The anti-inflammatory effect of Cur improved the inflammatory response in wounds dressed using ABCC, BCC 0.1 , and ABCC 0.1 . [44] This effect was particularly pronounced in the ABCC 0.1 wound, the damaged area of which displayed only a small number of inflammatory cells (black arrow), as opposed to more fibroblasts (blue arrow), blood vessels (green arrow), and a newly formed squamous epithelium (dashed green box). On day 14 following injury, few inflammatory cells were still present near the control, ABC, and ABCC wounds.…”
An asymmetric wound dressing acts as a skin‐like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver‐metal organic frameworks (Ag‐MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti‐bacterial activities. Compared to BC‐based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full‐thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC‐based dressing.
“…The anti-inflammatory effect of Cur improved the inflammatory response in wounds dressed using ABCC, BCC 0.1 , and ABCC 0.1 . [44] This effect was particularly pronounced in the ABCC 0.1 wound, the damaged area of which displayed only a small number of inflammatory cells (black arrow), as opposed to more fibroblasts (blue arrow), blood vessels (green arrow), and a newly formed squamous epithelium (dashed green box). On day 14 following injury, few inflammatory cells were still present near the control, ABC, and ABCC wounds.…”
An asymmetric wound dressing acts as a skin‐like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver‐metal organic frameworks (Ag‐MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti‐bacterial activities. Compared to BC‐based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full‐thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC‐based dressing.
“…The polysaccharide-based nanocarriers can deliver the drug to the intestinal tract, as shown in Figure 3A, preventing damage caused by gastric acid. 104 Oral drug design has extensively used acetylated starch; less substituted acetylated starch is more effective in colon-specific drug delivery systems. 105 Zhang et al 106 used a layer-by-layer alternating electrostatic assembly method to create carboxymethylated starch nanocapsules.…”
Section: Field Of Biomedicinementioning
confidence: 99%
“…This is crucial for extending the half-life of drugs in circulation, lowering the total dosage, and enhancing the bioavailability of drugs. The polysaccharide-based nanocarriers can deliver the drug to the intestinal tract, as shown in Figure A, preventing damage caused by gastric acid …”
Section: Applications
Of Modified Polysaccharides In
the Fields Of Ag...mentioning
Polysaccharides
are an important class of biomolecules derived
from several sources. However, the inherent structure of polysaccharides
prevents them from exhibiting favorable physicochemical properties,
which restricts their development in agriculture, industry, food,
and biomedicine. This paper systematically summarizes the changes
in the primary and advanced structures of modified polysaccharides,
and focuses on the effects of various modification methods on the
hydrophobicity, rheological properties, emulsifying properties, antioxidant
activity, hypoglycemic, and hypolipidemic activities of polysaccharides.
Then there is a list the applications of modified polysaccharides
in treating heavy metal pollutants, purifying water resources, improving
beverage stability and bread quality, and precisely delivering the
drug. When summarized and reviewed, the information above can shed
further light on the relationship between polysaccharide structure
and function. Determining the structure–activity relationship
provides a scientific basis for the direction of molecular modifications
of polysaccharides.
“…2 However, curcumin application suffers from certain limitations, including poor solubility, unstable chemical properties, photodegradability, fast metabolic rate, and low bioavailability. 3,4 To overcome these challenges, researchers have developed delivery systems based on bio-macromolecules such as proteins and polysaccharides. Examples of such systems include hydrogels, nanoparticles, and emulsions.…”
In this work, zein-Tamarind seed polysaccharide (TSP) co-delivery system was fabricated using antisolvent precipitation method. The formation mechanism, characterization, and alleviating colitis and gut microbiota dysbiosis in mice of Zein-TSP-curcumin...
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