Polysaccharides as a promising platform for the treatment of spinal cord injury: A review

Yang, Yuanli; Fan, Rangrang; Li, Hui; Chen, Haifeng; Gong, Hanlin; Guo, Gang

doi:10.1016/j.carbpol.2023.121672

Cited by 2 publications

(1 citation statement)

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“…The spinal cord is affected by external forces or chronic compression, and the corresponding sensory, motor and autonomic nervous functions are impaired owing to factors such as inflammation and apoptosis ( 101 ). Nerve cells have poor regenerative ability and cannot be cured after being damaged; therefore, treatment and rehabilitation after SCI are challenging ( 102 ). Differentially expressed lncRNAs play a regulatory role in SCI, providing new ideas for its treatment ( 103 ).…”

Section: Research Progress On Lncrnas In Scimentioning

confidence: 99%

Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)

Ma,

Liu,

Zhang

et al. 2024

Mol Med Rep

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Spinal diseases, including intervertebral disc degeneration (IDD), ankylosing spondylitis, spinal cord injury and other non-infectious spinal diseases, severely affect the quality of life of patients. Current treatments for IDD and other spinal diseases can only relieve symptoms and do not completely cure the disease. Therefore, there is an urgent need to explore the causes of these diseases and develop new treatment approaches. Long non-coding RNA (lncRNA), a form of non-coding RNA, is abundant in diverse sources, has numerous functions, and plays an important role in the occurrence and development of spinal diseases such as IDD. However, the mechanism of action of lncRNAs has not been fully elucidated, and significant challenges remain in the use of lncRNAs as new therapeutic targets. The present article reviews the sources, classification and functions of lncRNAs, and introduces the role of lncRNAs in spinal diseases, such as IDD, and their therapeutic potential.

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Section: Research Progress On Lncrnas In Scimentioning

confidence: 99%