Polysaccharide-rich extract from Polygonatum sibiricum protects hematopoiesis in bone marrow suppressed by triple negative breast cancer

Xie, Ying; Jiang, Ziwei; Yang, Rui; Ye, Yiyi; Pei, Lixia; Xiong, Si; Wang, Shunchun; Wang, Lisheng; Liu, Sheng

doi:10.1016/j.biopha.2021.111338

Cited by 28 publications

(20 citation statements)

References 44 publications

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“…33 In triple-negative breast cancer, the polysaccharide extracted from Polygonatum sibiricum decreased the population of myeloid cells and hematopoietic cell expansion in the spleen, suggesting the anti-breast cancer function. 34 In the P. sibiricum, there are 64 chemical compounds with main parts as rhamnetin, wogonin, chrysosplenetin B, dauriporphine, and 5-hydroxyl-7,8-panicolin, whose targets include Akt, MAPK14, PIK3CG, and GSK3 of kinases and cell death-related p53, NOS2, and SCN5A, as almost half drug-targeted compounds are related to anti-cancer by network pharmacology analysis, 35 which is consistent with our current results. The screened top-ranked targets of Akt 35 are similar to our results based on whole chemical component database analysis.…”

Section: ■ Discussionsupporting

confidence: 89%

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Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity

et al. 2022

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A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds.

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Section: ■ Discussionsupporting

confidence: 89%

“…In triple-negative breast cancer, the polysaccharide extracted from Polygonatum sibiricum decreased the population of myeloid cells and hematopoietic cell expansion in the spleen, suggesting the anti-breast cancer function . In the P.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity

et al. 2022

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“…In Balb/c female mice bearing triple negative breast cancer (TNBC), polysaccharide-rich extract from P. sibiricum (PREPS) could protect hematopoiesis through inhibiting hematopoietic cell expansion in spleen, as well as markedly increase hematopoietic stem and progenitor cells and common lymphoid progenitors in the bone marrow [ 130 ]. PREPS may show long-lasting anti-tumor effects in assisting TNBC therapies through sustaining hematopoiesis and lymphoid regeneration in bone marrow [ 130 ].…”

Section: Applications For Health-promoting Activitiesmentioning

confidence: 99%

Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides

Wang

et al. 2023

Molecules

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Polygonati Rhizoma, a typical homology of medicine and food, possesses remarkable anti-fatigue, anti-aging, metabolic regulatory, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetes, and anti-cancer effects. Among bioactive phytochemicals in Polygonati Rhizoma, polysaccharides play important roles in the health-promoting activities through the mechanisms mentioned above and potential synergistic effects with other bioactives. In this review, we briefly introduce the updated biosynthesis of polysaccharides, the purification method, the structure characterization, and food applications, and discuss in detail the biological activities of Polygonati Rhizoma polysaccharides and associated mechanisms, aiming at broadening the usage of Polygonati Rhizoma as functional food and medicine.

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“…Diverse flavones [ 2 ], homoisoflavanones [ 3 ], alkaloids [ 4 ], steroid saponins [ 5 ], triterpenoid saponins [ 6 ], polysaccharides [ 7 ] and their derivatives were isolated from this species in past studies. Past studies also showed that this herb exhibited anti-aging [ 7 , 8 ], anti-inflammatory [ 9 , 10 ], anti-osteoporotic [ 11 , 12 ], immune enhancing [ 13 , 14 ], neuroprotective [ 15 ], anti-diabetic [ 16 ], anticancer [ 17 ], and sleep-promoting [ 18 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum

2022

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Polygonatum sibiricum (Asparagaceae) is often used as an herbal drug in the traditional medicine of Southeast Asia. Its rhizome, called “Huang Jing”, is used in traditional Chinese medicine as an immune system stimulant, hypolipidemic agent, anti-aging agent, anti-fatigue agent, and cardiovascular protectant. We investigated the antioxidant, anti-acetylcholinesterase (AChE), anti-inflammatory, and anti-α-glucosidase effects of various solvent extracts and major bioactive components of Polygonatum sibiricum (PS) and processed Polygonatum sibiricum (PPS). Dichloromethane extract of PS showed stronger antioxidant effects by DPPH, ABTS, and FRAP assays, and EtOAc extract displayed relatively high antioxidant activity by a superoxide radical scavenging test. Moreover, acetone, EtOAc, and dichloromethane extracts displayed a significant anti-α-glucosidase effect. EtOH and CH2Cl2 extracts showed effective AChE inhibitory activity. In addition, dichloromethane extract showed the best inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) accumulation in RAW264.7 macrophages. HPLC analysis was used to investigate and compare the content of major active components of various solvent extracts of PS and PPS. Rutin showed the most effective scavenging of DPPH and ABTS free radicals, while scopoletin and isoquercetin displayed the strongest anti-α-glucosidase and anti-AChE effect, respectively. Rutin showed the best inhibition against LPS-induced NO production and also inhibited inducible nitric oxide synthase (iNOS) expression in Western blot. The molecular docking of AChE and iNOS revealed that active components could have a better antagonistic effect than positive controls (common inhibitors). This study shows that the active extracts and components of Polygonatum sibiricum have the potential to be further developed as a natural anti-AChE, anti-α-glucosidase, antioxidant and anti-inflammatory agent.

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Polysaccharide-rich extract from Polygonatum sibiricum protects hematopoiesis in bone marrow suppressed by triple negative breast cancer

Cited by 28 publications

References 44 publications

Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity

Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity

Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides

Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum

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