Polysaccharide isolated from fermented barley activates innate immune system and anti-tumor metastasis in mice

Jo, Minjeong; Jung, Jee‐Hoon; Kim, Han Wool; Lee, Sue Jung; Min, Young; Jee, Hee Sook; Yoon, Tae‐Jong; Shin, Kihyun

doi:10.1016/j.jcs.2020.102919

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…For example, a polysaccharide with anti-tumor activity was isolated after the in vitro fermentation of barley (sequential treatment of steamed ground barley grains with amylase hydrolysis, followed by yeast fermentation using S. cerevisiae, and then bacterial fermentation with Weissella cibaria). The polysaccharide was tested in vivo and showed antimetastatic properties through the promotion of NK cells' cytolytic activity and the activation of macrophages [89]. A L. brevis strain was also used to produce sourdough bread with anti-hypertensive properties.…”

Section: Cereal-based Fermented Foods As Probiotic Carriersmentioning

confidence: 99%

Fermented Cereal-based Products: Nutritional Aspects, Possible Impact on Gut Microbiota and Health Implications

Tsafrakidou

Michaelidou

Βiliaderis

2020

Foods

115

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Fermentation, as a process to increase the security of food supply, represents an integral part of food culture development worldwide. Nowadays, in the evolving functional food era where new sophisticated technological tools are leading to significant transformations in the field of nutritional sciences and science-driven approaches for new product design, fermentation technology is brought to the forefront again since it provides a solid foundation for the development of safe food products with unique nutritional and functional attributes. Therefore, the objective of the present review is to summarize the most recent advances in the field of fermentation processes related to cereal-based products. More specifically, this paper addresses issues that are relevant to nutritional and health aspects, including their interrelation with intestinal (gut) microbiome diversity and function, although clinical trials and/or in vitro studies testing for cereal-based fermented products are still scarce.

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Section: Cereal-based Fermented Foods As Probiotic Carriersmentioning

confidence: 99%

Fermented Cereal-based Products: Nutritional Aspects, Possible Impact on Gut Microbiota and Health Implications

Tsafrakidou

Michaelidou

Βiliaderis

2020

Foods

115

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“…Cytokines are mainly small molecule polypeptides or glycoproteins synthesized and secreted by immune cells. Cytokines can mediate the interaction between cells and regulate the immune response, including the production of interleukins (IL), interferons (IFN), and tumor necrosis factor (TNF) [ 60 , 61 , 62 ]. Th0 cells can form Th1 cells after encountering IL-12.…”

Section: Discussionmentioning

confidence: 99%

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

et al. 2021

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In this investigation, to maximize the desired immunoenhancement effects of PsEUL and stimulate an efficient humoral and cellular immune response against an antigen, PsEUL and the model antigen ovalbumin (OVA) were coupled using the N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) reaction to yield a novel delivery system (PsEUL-OVA). The physicochemical characteristics and immune regulation effects of this new system were investigated. We found the yield of this EDC method to be 46.25%. In vitro, PsEUL-OVA (200 μg mL−1) could enhance macrophage proliferation and increase their phagocytic efficiency. In vivo, PsEUL-OVA could significantly increase the levels of OVA-specific antibody (IgG, IgG1, IgG2a, and IgG2b) titers and cytokine (IL-2, IL-4, IL-6, IFN-γ) levels. Additionally, it could activate T lymphocytes and facilitate the maturation of dendritic cells (DCs). These findings collectively suggested that PsEUL-OVA induced humoral and cellular immune responses by promoting the phagocytic activity of macrophages and DCs. Taken together, these results revealed that PsEUL-OVA had the potential to improve immune responses and provide a promising theoretical basis for the design of a novel delivery system.

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“…This is the first study prospectively assessing the impact of fermented food on clinical outcomes in cancer patients undergoing chemotherapy. Furthermore, a recent Korean study showed that a polysaccharide called BF-E2-P, isolated from fermented barley, could activate the innate immune system and anti-tumor metastasis in mice [ 96 ]. BF-E2-P stimulated macrophages and cytokine production.…”

Section: Nutritional Interventions Modulating Gut Microbiota During Cancer Therapymentioning

confidence: 99%

“…BF-E2-P stimulated macrophages and cytokine production. Also, intravenous administration of BF-E2-P increased natural killer cell-mediated cytotoxicity against cancer cells and increased the production of IFN- γ [ 96 ], counteracting tumor growth [ 97 ]. Future randomized controlled studies are required to confirm these results and better understand the potential role of fermented functional food supplementation as a therapeutic tool.…”

Section: Nutritional Interventions Modulating Gut Microbiota During Cancer Therapymentioning

confidence: 99%

Nutritional Interventions Targeting Gut Microbiota during Cancer Therapies

Rinninella

Raoul

Cintoni³

et al. 2021

Microorganisms

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The gut microbiome is increasingly being recognized for its influence on intestinal and extra-intestinal disorders such as cancer. Today, diet is the most studied environmental modulator of gut microbiota, capable of altering or improving it in terms of richness and diversity. Recent evidence from several preclinical and clinical trials suggested that gut microbiota composition could modulate cancer therapies (toxicities, treatment responses) and vice versa. This review highlights the latest research on the bidirectional associations between gut microbiota and cancer. We also dissect the role of gut microbiota during cancer therapies in terms of toxicity and treatment response and, in turn, how cancer therapies could impact gut microbiota composition and functions. In this context, we summarize the state-of-the-art research regarding the role of various nutritional interventions—prebiotics, dietary strategies, and dietary restrictions—as cutting-edge possibilities to modulate gut microbiota during cancer therapies.

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Polysaccharide isolated from fermented barley activates innate immune system and anti-tumor metastasis in mice

Cited by 16 publications

References 26 publications

Fermented Cereal-based Products: Nutritional Aspects, Possible Impact on Gut Microbiota and Health Implications

Fermented Cereal-based Products: Nutritional Aspects, Possible Impact on Gut Microbiota and Health Implications

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

Nutritional Interventions Targeting Gut Microbiota during Cancer Therapies

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