Polysaccharide-based nanogels for drug and gene delivery

Recent Advances of Pullulan and/or Dextran-Based Materials for Bone Tissue Engineering Strategies in Preclinical Studies: A Systematic Review

“…Physical cross-linking and chemical cross-linking were used for hydrogels ( Kumari and Badwaik, 2019 ). Physically cross-linked of dextran-derived biomaterials were identified in two studies by using ionic cross-linking [e.g., calcium chloride ( Abbah et al, 2012 )] or by micellar reaction [e.g., sodium dodecyl sulfate/stearyl methacrylate ( Fang et al, 2019 ) (SDS/SMA) micelles].…”

“…No chemical modification was reported for compositions using both polysaccharides (Fricain et al, 2013;Schlaubitz et al, 2014;Frasca et al, 2017;Ribot et al, 2017;Fricain et al, 2018;Maurel et al, 2021). Physical cross-linking and chemical cross-linking were used for hydrogels (Kumari and Badwaik, 2019). Physically crosslinked of dextran-derived biomaterials were identified in two studies by using ionic cross-linking [e.g., calcium chloride (Abbah et al, 2012)] or by micellar reaction [e.g., sodium dodecyl sulfate/ stearyl methacrylate (Fang et al, 2019) (SDS/SMA) micelles].…”

CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review

“…72,73 The nanogels can be those that are liposome modied, micellar type, and hybrid nanogels. These types of nanogels have the ability to form a complex with various substances like proteins, drugs, and DNA molecules 36 and possess various desirable features such as reversibility, no chemical reactions, and/or toxic bioactive agents. 35 When utilizing associating polymers, it might be challenging to create stable physically cross-linked nanogels with regulated sizes due to the relative weakness of their non-covalent contacts.…”

Recent advances and challenges on chitosan-based nanostructures by polyelectrolyte complexation and ionic gelation for anthocyanins stabilization

“…Its structure is composed of repeated units of alternating sulfated disaccharides (glucuronic acid and N-acetylgalactosamine residues), linked by glycosidic bonds β-(1 → 3). The sulfonate groups of chondroitin sulfate occur mainly in the hydroxyls in C4 and C6 of the Nacetylgalactosamine unit, and C2 of the glucuronic acid (Kumari, & Badwaik, 2019).…”

“…Besides composing a large part of the extracellular matrix of various connective tissues such as skin, bone, cartilage, ligaments, and tendons, CHS is involved in several biochemical activities such as antioxidants, anticoagulants, and antiinflammatory. (Kumari, & Badwaik, 2019;Shariatinia, & Barzegari, 2019). This natural polysaccharide has also been the subject of much research in the field of nanotechnology, including the formation of nanostructured systems with chitosan.…”