Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Abstract

Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, and remodeling stages. In order to realize comprehensive and systematic wound management, appropriate wound treatment bio-adhesives are urgently needed. Hydrogel bio-adhesives have excellent properties and show unique and remarkable advantages in the field of wound management. This review begins with a detailed description of the design criteria and functionalities of ideal hydrogel bio-adhesives for wound healing. Then, recent advances in polysaccharide-based multifunctional hydrogel bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, and other polysaccharides, are comprehensively discussed. Finally, the current challenges and future research directions of polysaccharide-based hydrogel bio-adhesives for wound healing are proposed to stimulate further exploration by researchers.

Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers

“…For instance, for wound healing applications, alginate-based hydrogels have been suggested. In this case, partial oxidation and dopamine functionalization are needed to promote biodegradability and bioadhesion, respectively [ 45 ].…”

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review

“…Microorganism origin of polysaccharides is dextran, and animal-derived polysaccharides are chitin, hyaluronic acid, and heparin. [51][52][53][54] Kenawy et al 55 used electrospinning to fabricate polyvinyl alcohol (10%) and dextran (5%), and obtained nano-bers are crosslinked with sodium ampicillin loaded citric acid (10%). Addition of citric acid enhanced mechanical and thermal stability of nanobers.…”

Comparison study of surface-initiated hydrogel coatings with distinct side-chains for improving biocompatibility of polymeric heart valves

“…Surface coating modification is regarded as a crucial approach to modulating the interaction between solid materials and their external environments. 17 Hydrogel represents a fascinating soft material characterized by outstanding lubrication, [18][19][20] biocompatibility, [21][22][23] a versatile formulation, [24][25][26] and adjustable functionalities. [27][28][29] These attributes collectively bestow upon hydrogels immense potential in creating functional surface coatings.…”