Polysaccharide-based films for the prevention of unwanted postoperative adhesions at biological interfaces

Mayes, Sarah; Davis, Jessica; Scott, Jessica; Aguilar, Vanessa; Zawko, Scott A.; Swinnea, Steve; Peterson, Daniel L.; Hardy, John G.; Schmidt, Christine E.

doi:10.1016/j.actbio.2020.02.027

Cited by 36 publications

(31 citation statements)

References 60 publications

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“…The research found that GMHA based films can successfully prevent adhesions with statistical equivalence to the commercial antiadhesion Seprafilm. [ 142 ] Tamanna et al. developed thermal stimuli‐responsive hyaluronic acid and cellulose‐based physical hydrogel for the prevention of postsurgical de novo peritoneal adhesion.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

“…This hydrogel film showed good antiadhesive property statistically equivalent to Seprafilm. [ 142 ] Alginate based nanofiber membrane was developed to prevent postsurgical tendon‐sheath adhesions. [ 152 ] Guardix‐SG is a thermosensitive antiadhesive consisting of alginate, CaCl 2 , and poloxamer, forming gel at body temperature and providing a physical barrier for up to 21 days.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

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Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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“…The result demonstrated that the GMHA could resist platelet adhesion and improve the proliferation of murine osteoblastic cell line MC-3T3-E1. In another study, Mayes et al utilized alginate and GMHA to fabricate a robust hydrogel film, which showed a good ability of anti-adhesion in a rat peritoneal abrasion model for adhesion formation [74] (Figure 4a). Ma et al utilized GMHA and poly(γ-glutamic acid) to fabricate an injectable hydrogel, which showed excellent anti-compression ability and outstanding shape recovery capability [75].…”

Section: Crosslinking With Glycidyl Methacrylatementioning

confidence: 99%

“…The GMHA showed a good printability and ability of anti-adhesion. (a) The hydrogel film composed of alginate and GMHA[74]. (b) GMHA hydrogel[76].…”

mentioning

confidence: 99%

Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

Xing

Zhou

Hui³

et al. 2020

Nanotechnology Reviews

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Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

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“…Various products, including sprays, hydrogels, and membranes, have been used to prevent tissue adhesions [ [17] , [18] , [19] , [20] , [21] , [22] ]. However, only a few functional anti-adhesion materials can be used for pericardial reconstruction since a few materials can meet all the three requirements above [ [23] , [24] , [25] ].…”

Section: Introductionmentioning

confidence: 99%

A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery

Jin

Yang

et al. 2022

Bioactive Materials

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Pericardial barrier destruction, inflammatory cell infiltration, and fibrous tissue hyperplasia, trigger adhesions after cardiac surgery. There are few anti-adhesion materials that are both functional and sutureable for pericardial reconstruction. Besides, a few studies have reported on the mechanism of preventing pericardial adhesion. Herein, a functional barrier membrane with sutureability was developed via a modified electrospinning method. It was composed of poly( l -lactide- co -caprolactone) (PLCL) nanofibers, poly(vinyl alcohol) (PVA) aerogel, and melatonin, named PPMT. The PPMT had a special microstructure manifested as a staggered arrangement of nanofibers on the surface and a layered macroporous aerogel structure in a cross-section. Besides providing the porosity and hydrophilicity obtained from PVA, the structure also had suitable mechanical properties for stitching due to the addition of PLCL nanofibers. Furthermore, it inhibited the proliferation of fibroblasts by suppressing the activation of Fas and P53 , and achieved anti-inflammatory effects by affecting the activity of inflammatory cells and reducing the release of pro-inflammatory factors, such as interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α). Finally, in vivo transplantation showed that it up-regulated the expression of matrix metalloproteinase-1 (MMP1) and tissue inhibitor of metalloproteinase-1 (TIMP1), and down-regulated the expression of Vinculin and transforming growth factor β (TGF-β) in the myocardium, thereby reducing the formation of adhesions. Collectively, these results demonstrate a great potential of PPMT membrane for practical application to anti-adhesion.

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Polysaccharide-based films for the prevention of unwanted postoperative adhesions at biological interfaces

Cited by 36 publications

References 60 publications

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery

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